Center for Protein Therapeutics Symposium

Faculty, post-doctoral fellows and graduate students from the School of Pharmacy and Pharmaceutical Sciences present the results of ten research projects that were funded by the CPT during the past year. 

12th Annual Center for Protein Therapeutics Symposium
Monday, August 10, 2020
Cost: No fee
Location: WebEx
https://ub.webex.com/ub/j.php?MTID=m04adfffb16fb3d647fc171e52488a0d6

Agenda

Time Presentation Presenter/Lab
8:50 a.m. Introduction to the Annual CPT Symposium Joseph Balthasar
9:00 a.m. Hepatic FcRn and the Impact of its Loss on FcRn-Mediated Recycling Marilyn Morris
9:30 a.m. BCSFB transport and disposition of IgG1 Marilyn Morris
10:00 a.m. Evaluation of Brain Pharmacokinetics of Protein Therapeutics after Local Administration Dhaval Shah
10:30 a.m. Break  
11:00 a.m. Evaluation of CAR-Bomb strategies for targeted delivery of anti-cancer siRNA Joseph Balthasar
11:30 a.m. Study viable approaches for oral delivery of colonā€targeting macromolecules (e.g. targeting TNF for and the gut absorption mechanism following oral delivery Sathy Balu-Iyer
12:00 p.m. Break  
12:30 p.m. Evaluation of the effects of cell penetrating peptides and endosomal escape peptides on the pharmacokinetics of anti-cancer monoclonal antibodies Joseph Balthasar
1:00 p.m. Evaluation of the therapeutic selectivity of anti-CEA SN38 antibody-drug conjugates (ADC) and antibody drug fragment complexes (FDC) Joseph Balthasar
1:30 p.m. Effect of Charge Variation on the Disposition of Monoclonal Antibodies Dhaval Shah
2:00 p.m. Break  
2:30 p.m. 3D-printed micro scaffold for high-resolution tissue compartmentalization / micro-sampling and application in measuring the tissue distribution of protein biotherapeutics and biomarkers Jun Qu
3:00 p.m. Evaluation of pH Dependent Antigen Binding and Geldanamycin Co-administration as Novel Strategies for Enhanced Intracellular Delivery of Antibody-Drug Conjugates (ADCs) Dhaval Shah
3:30 p.m. Liposomal IL-12 protects melanoma patient-derived tumor-specific T cells from an up regulation of PD-1, exhaustion and loss of function following their adoptive transfer and entry into the tumor microenvironment of melanoma tumor xenografts Donald Mager
4:00 p.m. Concluding Remarks Joseph Balthasar