Current Funded Projects

Fiscal Year 2019

Title Sponsor PI Project Period Total Amount
HL-Development and Pharmacology of novel lipidic rAHF and biotherapeutics National Heart, Lung and Blood Institute Balu-Iyer. Dr. Sathy V. Apr. 2002 - Dec. 2019 $5,013,684
AIDS Clinical Trials Group, Pharmacology Specialty Laboratory, Federal Flow-through: Task Order 1 SSS National Institute of Allergy and Infectious Diseases Morse, Dr. Gene D. Jan. 2014 - Nov. 2020 $2,157,575
Translational Systems Pharmacokinetic Models of Novel Anticancer Biologics National Institute of General Medical Science Shah, Dr. Dhaval K. May 2015 - Mar. 2020 $1,650,448
Clinical Pharmacology Quality Assurance and Quality Control National Institute of Allergy and Infectious Disease Morse, Dr. Gene D. May 2015 - May 2022 $12,079,663
Catch and Release Immunotoxins: CAR-Bombs for Cancer National Cancer Institute Balthasar, Dr. Joseph P. Dec. 2016 - Nov. 2021 $1,800,000
Global Infectious Diseases Research Training Program Fogarty International Center Morse, Dr. Gene D. 2018 - 2023 $1,100,000
Center for Health + Technology (CHeT) University of Rochester Morse, Dr. Gene D. Jul. 2018 - Jun. 2019 $12,000
Age and Race Influences on Immunosuppression after Renal Transplant National Institute on Aging Tornatore-Morse, Dr. Kathleen M. Aug. 2018 - Jun. 2023 $3,507,814
Tumor selectivity of anti-carcinoembryonic antigen scFv, scFv-ABD, and monoclonal Center for Protein Therapeutics Balthasar, Dr. Joseph P. FY2019 $100,000
Dynamic contrast enhanced magnetic resonance imaging for the prediction of monoclonal Center for Protein Therapeutics Balthasar, Dr. Joseph P. FY2019 $100,000
Study viable approaches for oral delivery of colon-targeting macromolecules (e.g. targeting TNF for IBD), and understand the gut absorption mechanism following oral delivery Center for Protein Therapeutics Balu-Iyer, Dr. Sathy V. FY2019 $100,000
PK/PD Modeling of Liposomal IL-12 Enhancement of Human Tumor-Specific T Cell Killing In A Novel Center for Protein Therapeutics Mager, Dr. Donald E. FY2019 $100,000
BCSFB transport of protein therapeutics: Influence of Type 2 Diabetes Center for Protein Therapeutics Morris, Dr. Marilyn E. FY2019 $100,000
Visualizing the Renal Disposition of Proteins and Peptides using Two-Photon Microscopy Center for Protein Therapeutics Morris, Dr. Marilyn E. FY2019 $38,500
Sensitive, accurate investigation of biotherapeutics and biomarker/target levels in both fresh and FFPE tissues, and application in Inflammatory bowel diseases Center for Protein Therapeutics Qu, Dr. Jun FY2019 $100,000
Extensive investigation of ocular tissue disposition of antibody-drug conjugates and the ocular toxicity using novel LC-MS-based strategies Center for Protein Therapeutics Qu, Dr. Jun FY2019 $38,500
Brain Pharmacokinetics of Different Size Antibody Fragments Center for Protein Therapeutics Shah, Dr. Dhaval K. FY2019 $100,000
Clinical Validation of Antibody PBPK Model Using 89Zr Labelled Imaging Studies Center for Protein Therapeutics Shah, Dr. Dhaval K.  FY2019 $100,000
Multiparametric MRI-based physiological imaging to predict mAb penetration and efficacy in pancreatic cancer Center for Protein Therapeutics Straubinger, Dr. Robert M. FY2019 $100,000
Opioid Prescriber Training Program and Enduring Program Health Research Inc Bednarczyk, Dr. Edward M. Sep. 2018 - Aug. 2019 $81,100
Physiologically-based model of the female reproductive tract: vaginal and intrauterine delivery components- Support New Approaches to Improve Product Manufacturing and Quality US Food and Drug Administration Bies, Dr. Robert R. Sep. 2018 - Sep. 2020  
Immunologic and Neurodevelopmental Consequences of Neonatal Anemia and Thrombocytopenia and their Treatments Childrens Hospital of Boston Mager, Dr. Donald E. Sep. 2018 - Jun. 2023 $644,233
T Regulatory Cell Response to Erythropoiesis Stimulating Agents Post-Renal Transplantation American College of Clinical Pharmacy Meaney, Dr. Calvin J. Nov. 2018 - Oct. 2019 $5,000
GMPS-GMPR axis melanoma progression and therapy Wake Forest University Health Sciences Qu, Dr. Jun Nov. 2018 - Apr. 2023 $103,700
Large-scale proteome-wide analysis with high accuracy/precision to guide pancreatic cancer therapy development National Cancer Institute Straubinger, Dr. Robert M. Dec. 2018 - Nov. 2020 $398,683
Regulation of SGLT1 function by tyrosine kinase inhibitors American Association of Colleges of Pharmacy Sprowl, Dr. Jason A. Feb. 2019 - Jan. 2020 $9,864
Mechanistic Pharmacokinetics and Pharmacodynamics National Institute of General Medical Sciences Jusko, Dr. William J. May 2019 - Apr. 2024 $2,891,677
Visiting Scholar: Nikhil Pillai Merck Sharp and Dohme Corporation Bies, Dr. Robert R. May 2019 - May 2020 $26,000