Current Funded Projects

Fiscal Year 2019

Title Funding Type Sponsor PI Project Period Total Amount
HL-Development and Pharmacology of novel lipidic rAHF and biotherapeutics Federal National Heart, Lung and Blood Institute Balu-Iyer. Dr. Sathy V. Apr. 2002 - Dec. 2019 $5,013,684
Contribution of CBRs and AKRs to the Pharmacodynamics of Anthracycline Drugs Federal National Institutes of Health / National Institute of General Medical Science Blanco, Dr. Javier G. Mar. 2005 - Feb. 2020 $1,283,268
Defining the Contribution of Cellular Hypoxia to the Cardiotoxicity of Anticancer Anthracyclines and Trastuzumab Federal National Institute of General Medical Science Blanco, Dr. Javier G. Mar. 2005 - Aug. 2020 $159,000
AIDS Clinical Trials Group, Pharmacology Specialty Laboratory, Federal Flow-through: Task Order 1 SSS Federal National Institute of Allergy and Infectious Diseases Morse, Dr. Gene D. Jan. 2014 - Nov. 2020 $2,157,575
Translational Systems Pharmacokinetic Models of Novel Anticancer Biologics Federal National Institute of General Medical Science Shah, Dr. Dhaval K. May 2015 - Mar. 2020 $1,650,448
Clinical Pharmacology Quality Assurance and Quality Control Federal National Institute of Allergy and Infectious Disease Morse, Dr. Gene D. May 2015 - May 2022 $12,079,663
Catch and Release Immunotoxins: CAR-Bombs for Cancer Federal National Cancer Institute Balthasar, Dr. Joseph P. Dec. 2016 - Nov. 2021 $1,800,000
Epigenetic Regulation of FcRn Expression in Human Lung and its Role in the Disposition of Monoclonal Antibody Drugs Federal National Institutes of Health Blanco, Dr. Javier G. Mar. 2017 - Mar. 2020 $397,604
Global Infectious Diseases Research Training Program Non-federal Fogarty International Center Morse, Dr. Gene D. 2018 - 2023 $1,100,000
Age and Race Influences on Immunosuppression after Renal Transplant Federal National Institute on Aging Tornatore-Morse, Dr. Kathleen M. Aug. 2018 - Jun. 2023 $3,507,814
Physiologically-based model of the female reproductive tract: vaginal and intrauterine delivery components- Support New Approaches to Improve Product Manufacturing and Quality Federal US Food and Drug Administration Bies, Dr. Robert R. Sep. 2018 - Sep. 2020  
Immunologic and Neurodevelopmental Consequences of Neonatal Anemia and Thrombocytopenia and their Treatments Non-federal Childrens Hospital of Boston Mager, Dr. Donald E. Sep. 2018 - Jun. 2023 $644,233
T Regulatory Cell Response to Erythropoiesis Stimulating Agents Post-Renal Transplantation Non-federal American College of Clinical Pharmacy Meaney, Dr. Calvin J. Nov. 2018 - Oct. 2019 $5,000
GMPS-GMPR axis melanoma progression and therapy Non-federal Wake Forest University Health Sciences Qu, Dr. Jun Nov. 2018 - Apr. 2023 $103,700
Large-scale proteome-wide analysis with high accuracy/precision to guide pancreatic cancer therapy development Federal National Cancer Institute Straubinger, Dr. Robert M. Dec. 2018 - Nov. 2020 $398,683
Regulation of SGLT1 function by tyrosine kinase inhibitors Non-federal American Association of Colleges of Pharmacy Sprowl, Dr. Jason A. Feb. 2019 - Jan. 2020 $9,864
Mechanistic Pharmacokinetics and Pharmacodynamics Federal National Institute of General Medical Sciences Jusko, Dr. William J. May 2019 - Apr. 2024 $2,891,677
Visiting Scholar: Nikhil Pillai Non-federal Merck Sharp and Dohme Corporation Bies, Dr. Robert R. May 2019 - May 2020 $26,000
Evaluation of Brain Pharmacokinetics of Protein Therapeutics after Local Administration Non-federal Center for Protein Therapeutics Shah, Dr. Dhaval K. 2019-2020 $100,000
Evaluation of CAR-Bomb strategies for targeted delivery of anti-cancer siRNA Non-federal Center for Protein Therapeutics Balthasar, Dr. Joseph P. 2019-2020 $100,000
Study viable approaches for oral delivery of colon-targeting macromolecules (e.g. targeting TNF for IBD), and understand the gut absorption mechanism following oral delivery Non-federal Center for Protein Therapeutics Balu-Iyer, Dr. Sathy V. 2019-2020 $100,000
Evaluation of the effects of cell penetrating peptides and endosomal escape peptides on the pharmacokinetics of anti-cancer monoclonal antibodies Non-federal Center for Protein Therapeutics Balthasar, Dr. Joseph P. 2019-2020 $100,000
Evaluation of the therapeutic selectivity of anti-CEA SN38 antibody-drug conjugates (ADC) and antibody drug fragment complexes (FDC) Non-federal Center for Protein Therapeutics Balthasar, Dr. Joseph P. 2019-2020 $100,000
Hepatic FcRn and the Impact of its Loss on FcRn-Mediated Recycling Non-federal Center for Protein Therapeutics Morris, Dr. Marilyn E. 2019-2020 $38,500
3D-printed micro scaffold for high-resolution tissue compartmentalization / micro-sampling and application in measuring the tissue distribution of protein biotherapeutics and biomarkers Non-federal Center for Protein Therapeutics Qu, Dr. Jun 2019-2020 $100,000
Effect of Charge Variation on the Disposition of Monoclonal Antibodies Non-federal Center for Protein Therapeutics Shah, Dr. Dhaval K. 2019-2020 $38,500
Evaluation of pH Dependent Antigen Binding and Geldanamycin Co-administration as Novel Strategies for Enhanced Intracellular Delivery of Antibody-Drug Conjugates (ADCs) Non-federal Center for Protein Therapeutics Shah, Dr. Dhaval K. 2019-2020 $100,000
Liposomal IL-12 protects melanoma patient-derived tumor-specific T cells from an up regulation of PD-1, exhaustion and loss of function following their adoptive transfer and entry into the tumor microenvironment of melanoma tumor xenografts Non-federal Center for Protein Therapeutics Mager, Dr. Donald E. 2019-2020 $75,000
BCSFB transport and disposition of IgG1 Non-federal Center for Protein Therapeutics Morris, Dr. Marilyn E. 2019-2020 $75,000
The Who and Why of Anthracycline-related Cardiotoxicity in Childhood Cancer Survivors Non-federal V Foundation for Cancer Research Blanco, Dr. Javier G. July 2019 - June 2022 $64,369