EDUCATING LEADERS IN PHARMACY AND PHARMACEUTICAL SCIENCES SINCE 1886
Jun Qu PhD
Jun Qu
PhD
Professional Summary:
Jun Qu is a professor in the Department of Pharmaceutical Sciences of SUNY-Buffalo and the group leader of the Proteomics and Pharmaceutical Analysis lab in New York Center of Excellence in Bioinformatics and Life Sciences. His research is focused on the characterization of protein biotherapeutics and Clinical/Pharmaceutical Proteomics using novel LC/MS-based strategies. His research programs include i) highly sensitive and accurate investigation of biotherapeutics/markers/targets in pharmaceutical and clinical systems using innovative LC/MS approaches; ii) high-resolution and large-scale expression profiling of pathological proteomes using MS1-based proteomic methods; and iii) Sensitive identification, localization and quantification of post-translational modifications in tissue proteomes. His lab possesses many state-of-the-art LC/MS instruments, including Orbitrap Fusion Lumos MS, TSQ Altis triple-quadrupole MS, various high-performance LC systems, and state-of-the-art sample preparation techniques. A number of key analytical advances have been developed by his lab that greatly enhanced the depth, sensitivity and throughput for protein analysis.His group is one of the current world leaders in LC-MS-based study of biotherapeutics in pre-clinical models, as well as MS1-based quantitative proteomics and has >110 peer reviewed publications and >60 grants funded as PI or co-I.
Education and Training:
- PhD, Tsinghua University (2002)
Employment:
- Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2018-present)
- Adjunct Associate Professor, Roswell Park Cancer Institute (2013-present)
- Associate Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2012-present)
- Adjunct Assistant Professor, Biochemistry, University at Buffalo, Department of Biochemistry (2011-present)
- Adjunct Assistant Professor, Ophthalmology, University at Buffalo, Department of Ophthalmology (2010-present)
- chief scientist, New York Center of Excellence in Bioinformatics and Life ScienceNew York Center of Excellence in Bioinformatics and Life Science (2007-present)
- Graduate Faculty, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2007-present)
- Assistant Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2009–2013)
- Research Assistant Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2004–2008)
Awards and Honors:
- UB Exceptional Scholar Sustained Achievement Award (2019)
- Outstanding speaker award, Indian APA conference (2019)
- Outstanding contribution award for medicinal analysis (2015)
- Thermo Scientific Research Award (2015)
- Selected by the Chemistry Department of Tsinghua University as one of the ten most prominent alumni graduated 2000-2010. (2012)
- Delegate of the International Task Force for Vitamin D and MS Prevention (2011)
- Fellow of Buffalo Clinical and Translational Research Center (2011)
- American Heart Association Scientist Development Award (2011)
- Clinical and Translational Award of SUNY (2010)
- Chinese Association for Instrumental Analysis (2004)
- outstanding academic delegate and met with Chinese President Jiang Zhemin (2001)
- Chinese-Glories Scholarship (2000)
- Dr. Mei Yiqi Scholarship (1999)
- Dupont Distinguished Student Scholarship (1998)
Research Expertise:
- Pharmaceutical Analysis: Targeted quantification of regulatory, marker proteins for clinical study, using highly-sensitive nano-LC/SRM-based methods. A number of key analytical advances have been developed in his laboratory, which greatly enhance the proteomic coverage, sensitivity and throughput for proteomic research.
- Proteomics: i) high-resolution and large-scale expression profiling of pathological proteomes (e.g. for cardiovascular diseases, colon cancer and infectious diseases) for the discovery of disease/therapeutic biomarkers using gel-free LC/MS methods; ii) Sensitive identification, localization and quantification of post-translational modifications in complex proteomes; Here, novel anti-PTM-peptide capture procedures, and alternating collision induced dissociation /electron transferring dissociation methods are employed to obtain abundant PTM information;
Grants and Sponsored Research:
- September 2018–August 2023
The role of oral spirochete virulence factors in the impairment of neutrophil response
NIH
Role: Co-Investigator
$1,894,065 - August 2019–July 2021
Novel LC-MS strategies for comprehensive in vivo investigations of antibody-drug conjugates and toxicity biomarkers.
GSK Research
Role: Principal Investigator - July 2019–December 2020
Novel cancer-related proteases.
AbbVie SRA
Role: Principal Investigator - December 2018–November 2020
LARGE-SCALE PROTEOME-WIDE ANALYSIS WITH HIGH ACCURACY/PRECISION TO GUIDE PANCREATIC CANCER THERAPY DEVELOPMENT.
CA234775
Role: Principal Investigator - September 2019–August 2020
A 3D-printed micro-scaffold for MS Imaging and Spatially Resolved Determination of Mab and Receptors in Tissues.
Center for Protein Therapeutics
Role: Principal Investigator - September 2015–June 2020
Transcription mechanism of Myrf for central nervous system myelination.
NIH
Role: Co-Investigator - August 2014–May 2019
Function of Regulator of G protein signaling in aging skeleton
NIH/NIA
Role: Co-Investigator - June 2014–May 2019
Regulation of skeletal development and homeostasis by IFT protein
NIH/NIDCR
Role: Co-Investigator - January 2015–December 2018
PTPN14 and YAP tyrosine modification regulate the YAP oncogenic function
American Cancer Society (ACS)
Role: Co-Principal Investigator - December 2015–November 2017
A high-throughput LC/MS method for quantification of biotherapeutics
Roche-Pharmaceuticals
Role: Principal Investigator - September 2012–July 2017
Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies
NIDA
Role: Co-Investigator - June 2014–May 2017
Vitamin D and Children’s Diabetes
Murdoch Childrens Research Institute
Role: Principal Investigator - January 2012–December 2016
Biomarker Release after Reversible Ischemia
AHA
Role: Principal Investigator - September 2015–August 2016
Characterization of ADC in tissues and study of mAb catabolism/metabolism
Peer-reviewed Industry Consortium Funds
Role: Principal Investigator - July 2013–June 2016
Enrichment Toolkit for Proteomic Biomarkers
UB
Role: Principal Investigator - June 2014–May 2016
Investigation of the utility of LC/MS for characterization of the plasma and tissue PK of a novel series of antiCEA monocolonal antibodies.
Hoffmann-La Roche Inc
Role: Co-Investigator - January 2011–December 2015
Biomarker Release after Reversible Ischemia
American Heart Association
Role: Principal Investigator
$385,000 - December 2014–October 2015
Extensive investigation of protein binding in lipsome preparations
Merrimack Pharma
Role: Principal Investigator - June 2014–May 2015
Brain network: Membrane permeable transcriptional regulators for retinal repair
Center for Hearing and Deafness
Role: Principal Investigator - May 2010–April 2015
Protein arginine methylation in trypanosomes
NIH NIAID
Role: Co-Principal Investigator
$250,000 - May 2006–April 2015
Metabolic Adaptation and Functional Recovery of Hibernating Myocardium
NIH
Role: Co-Investigator - September 2012–August 2014
Subcellular domains of myelinating-glia: capturing axonal contact
NIH
Role: Co-Principal Investigator
$435,875
Journal Articles:
- Ma JH, Shen S, Wang JJ, He Z, Poon A, Li J, Qu J, Zhang SX. Comparative Proteomic Analysis of the Mitochondria-associated ER Membrane (MAM) in a Long-term Type 2 Diabetic Rodent Model. Sci Rep. 2017; 7(1).
- Aranda JV, Qu J, Valencia GB, Beharry KD.. Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity. Semin Perinatol.. 2019; 43(6).
- Jones RS, Tu C, Zhang M, Qu J, Morris ME. Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism. Mol. Pharmacol.. 2019; 96(3).
- Zhang J, Gelman IH, Katsuta E, Liang Y, Wang X, Li J, Qu J, Yan L, Takabe K, Hochwald SN.. Glucose Drives Growth Factor-Independent Esophageal Cancer Proliferation via Phosphohistidine-Focal Adhesion Kinase Signaling.. Cell Mol Gastroenterol Hepatol.. 2019; 8(1).
- Kafková L, Tu C, Pazzo KL, Smith KP, Debler EW, Paul KS, Qu J, Read LK.. Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response.. MBio.. 2018.
- Zhu X, Shen X, Qu J, Straubinger RM, Jusko WJ.. Multi-Scale Network Model Supported by Proteomics for Analysis of Combined Gemcitabine and Birinapant Effects in Pancreatic Cancer Cells. CPT Pharmacometrics Syst Pharmacol.. 2018.
- Ayyar VS, Sukumaran S, DuBois DC, Almon RR, Qu J, Jusko WJ. Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver. J Pharmacokinet Pharmacodyn. 2018; 45(4).
- Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D‘Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR, Feltri M. GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. J Exp Med. 2018; 215(3).
- Zhu X, Shen X, Qu J, Straubinger RM, Jusko WJ. Proteomic Analysis of Combined Gemcitabine and Birinapant in Pancreatic Cancer Cells. Front Pharmacol. 2018; 9.
- Liu G, Cheng K, Lo CY, Li J, Qu J, Neelamegham S. A Comprehensive, Open-source Platform for Mass Spectrometry-based Glycoproteomics Data Analysis. Mol Cell Proteomics. 2017; 16(11).
- Gururaj S, Evely KM, Pryce KD, Li J, Qu J, Bhattacharjee A. Protein Kinase A induced internalization of Slack channels from the neuronal membrane occurs by Adaptor Protein-2/Clathrin mediated endocytosis. J Biol Chem. 2017.
- Zhou S, Vazvaei F, Ferrari L, Qu J. Practical considerations in enhancing LC-MS sensitivity for therapeutic protein bioanalysis. Bioanalysis. 2017; 9(18).
- Fu W, An B, Wang X, Qu J. Key considerations for LC-MS analysis of protein biotherapeutics in tissues. Bioanalysis. 2017; 9(18).
- Shen X, Shen S, Li J, Hu Q, Nie L, Tu C, Wang X, Orsburn B, Wang J, Qu J. An IonStar Experimental Strategy for MS1 Ion Current-Based Quantification Using Ultrahigh-Field Orbitrap: Reproducible, In-Depth, and Accurate Protein Measurement in Large Cohorts. J Proteome Res. 2017; 16(7).
- Bima A, Pezic A, Sun C, Cameron FJ, Rodda C, van der Mei I, Chiaroni-Clarke R, Dwyer T, Kemp A, Qu J, Carlin J, Ellis JA, Ponsonby AL. Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children. J Pediatr Endocrinol Metab. 2017; 30(5).
- Tian Y, Jacinto MP, Zeng Y, Yu Z, Qu J, Liu WR, Lin Q. Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking. J Am Chem Soc. 2017; 139(17).
- Ayyar VS, Almon RR, DuBois DC, Sukumaran S, Qu J, Jusko WJ. Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism. J Proteomics. 2017.
- Weil BR, RF Young, X Shen, G Suzuki, JK Qu, S Malhotra and JM Canty, Jr.. Brief myocardial ischemia produces cardiac troponin I release and focal myocyte apoptosis in the absence of pathological infarction in swine. J Am Coll Cardiol Basic Trans Sci. 2017; 2(2).
- Chengjian Tu,Shichen Shen,Quanhu Sheng,Yu Shyr,Jun Qu.. Peptide-Retrieval Strategy Enables Significant Improvement of Quantitative Performance Without Compromising Confidence of Identification,. Journal of Proteomics. 2017; 152.
- Tu C, Mojica W, Straubinger R, Li, Jun, Shen, Shichen, Qu, Miao, Nie, Lei, Rick Roberts, An, Bo, Qu J. Quantitative proteomic profiling of paired cancerous and normal colon epithelial cells isolated freshly from colorectal cancer patients PROTEOMICS-Clinical Applications. 2016; 11.
- Welle KA, Zhang T, Hyrohorenko JR, Shen S, Qu J, Ghaemmaghami S.. Time-resolved analysis of proteome dynamics by TMT-SILAC hyperplexing. Mol Cell Proteomics. 2016.
- Li Y, Guo J, Li J, Yang N, Shen H, Frangou C, Wilson K, Zhang Y, Sudol M, Farooq A, Qu J and Zhang J.. Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation. Cell Cycle. 2016; 15(18).
- Tu C, Bu Y, Vujcic M, Shen S, Li J, Qu M, Hangauer D, Clements J, Qu J. Ion Current-based Proteomic Profiling in Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation. J Proteome Res. 2016; 15(9).
- Chengjian Tu, Jun Li, Shichen Shen, Quanhu Sheng, Yu Shyr, Jun Qu. Performance Investigation of Proteomic Identification by HCD/CID Fragmentations in Combination with High/Low-Resolution Detectors on a Tribrid, High-Field Orbitrap Instrument. PloS one. 2016; 11(7).
- Qu M, An B, Shen S, Zhang M, Shen X, Duan X, Balthasar JP, Qu J. Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry Mass Spectrom Rev. 2016.
- Tian Zhang,Shichen Shen,Jun Qu,Sina Ghaemmaghami. Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy. Cell Report. 2016; 14(10).
- Yuan X, Cao J, He X, Serra R, Qu J, Cao X, Yang S.. Ciliary IFT80 balances canonical versus non-canonical hedgehog signaling for osteoblast differentiation. Nat Commun. 2016.
- Shen S, Jiang X, Li J, Straubinger RM, Suarez M, Tu C, Duan X, Thompson AC, Qu J. Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal. J Proteome Res. 2016; 15(5).
- Shen S, Li J, Hilchey S, Shen X, Tu C, Qiu X, Ng A, Ghaemmaghami S, Wu H, Zand MS, Qu J.. Ion-Current-Based Temporal Proteomic Profiling of Influenza-A-Virus-Infected Mouse Lungs Revealed Underlying Mechanisms of Altered Integrity of the Lung Microvascular Barrier. J Proteome Res. 2016.
- Tu C, Sheng Q, Li J, Ma D, Shen X, Wang X, Shyr Y, Yi Z, Qu J. Optimization of Search Engines and Postprocessing Approaches to Maximize Peptide and Protein Identification for High-Resolution Mass Data. J Proteome Res. 2015; 14(11).
- Shen X, Nair B, Mahajan SD, Jiang X, Li J, Shen S, Tu C, Hsiao CB, Schwartz SA, Qu J. New Insights into the Disease Progression Control Mechanisms by Comparing Long-Term-Nonprogressors versus Normal-Progressors among HIV-1-Positive Patients Using an Ion Current-Based MS1 Proteomic Profiling. J Proteome Res. 2015.
- Shen X, Hu Q, Li J, Wang J, Qu J. Experimental Null Method to Guide the Development of Technical Procedures and to Control False-Positive Discovery in Quantitative Proteomics. J Proteome Res. 2015; 14(10).
- Morales Y, Nitzel DV, Price OM, Gui S, Li J, Qu J, Hevel JM. Redox Control of Protein Arginine Methyltransferase 1 (PRMT1) Activity. J Biol Chem. 2015; 290(24).
- Lott K, Mukhopadhyay S, Li J, Wang J, Yao J, Sun Y, Qu J, Read L. Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome. Nucleic Acids Research. 2015; 43(11).
- Tu C, Beharry KD, Shen X, Li J, Wang L, Aranda JV, Qu J. Proteomic profiling of the retinas in a neonatal rat model of oxygen-induced retinopathy with a reproducible ion-current-based MS1 approach. J Proteome Res. 2015; 14(5).
- An B, Zhang M, Johnson RW, Qu J. Surfactant-aided precipitation/on-pellet-digestion (SOD) procedure provides robust and rapid sample preparation for reproducible, accurate and sensitive LC/MS quantification of therapeutic protein in plasma and tissues. Anal Chem. 2015; 87(7).
- Kamisoglu K, Sukumaran S, Nouri-Nigjeh E, Tu C, Li J, Shen X, Duan X, Qu J, Almon RR, DuBois DC, Jusko WJ, Androulakis IP. Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: a systems approach to liver function in pharmacogenomics. OMICS. 2015; 19(2).
- Zhang T, Price JC, Nouri-Nigjeh E, Li J, Hellerstein MK, Qu J, Ghaemmaghami S. Kinetics of precursor labeling in stable isotope labeling in cell cultures (SILAC) experiments. Anal Chem. 2014; 86(22).
- Tu C, Sheng Q, Li J, Shen X, Zhang M, Shyr Y, Qu J. ICan: An Optimized Ion-Current-Based Quantification Procedure with Enhanced Quantitative Accuracy and Sensitivity in Biomarker Discovery. J Proteome Res. 2014.
- An B, Zhang M, Qu J.. Toward sensitive and accurate analysis of antibody biotherapeutics by liquid chromatography coupled with mass spectrometry. Drug Metab Dispos. 2014.
- Nouri-Nigjeh E, Sukumaran S, Tu C, Li J, Shen X, Duan X, DuBois DC, Almon RR, Jusko WJ, Qu J. Highly multiplexed and reproducible ion-current-based strategy for large-scale quantitative proteomics and the application to protein expression dynamics induced by methylprednisolone in 60 rats. Anal Chem. 2014; 86(16).
- Shen X, Young R, Canty JM, Qu J. Quantitative proteomics in cardiovascular research: Global and targeted strategies. Proteomics Clin Appl. 2014; 8(7-8).
- Browne RW, Weinstock-Guttman B, Zivadinov R, Horakova D, Bodziak ML, Tamaño-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J, Qu J, Havrdova E, Ramanathan M. Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study. J Steroid Biochem Mol Biol. 2014.
- Qu J, Young R, Page BJ, Shen X, Tata N, Li J, Duan X, Fallavollita JA, Canty JM. Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models J Proteome Res. 2014; 13(5).
- Tu C, Li J, Sheng Q, Zhang M, Qu J. Systematic assessment of survey scan and MS2-based abundance strategies for label-free quantitative proteomics using high-resolution MS data. J Proteome Res. 2014; 13(4).
- Nouri-Nigjeh E1, Zhang M, Ji T, Yu H, An B, Duan X, Balthasar J, Johnson RW, Qu J.. Effects of Calibration Approaches on the Accuracy for LC/MS Targeted Quantification of Therapeutic Protein. Anal Chem.. 2014; 86(7).
- Tu C, Li J, Jiang X, Sheflin LG, Pfeffer BA, Behringer M, Fliesler SJ, Qu J. Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome. Mol Cell Proteomics. 2013; 12(12).
- Zivadinov R, Treu CN, Weinstock-Guttman B, Turner C, Bergsland N, O‘Connor K, Dwyer MG, Carl E, Ramasamy DP, Qu J, Ramanathan M. Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis.. J Neurol Neurosurg Psychiatry. 2013; 84(10).
- Lott K, Li J, Fisk JC, Wang H, Aletta JM, Qu J, Read LK.. Global proteomic analysis in trypanosomes reveals unique proteins and conserved cellular processes impacted by arginine methylation J Proteomics.. 2013.
- Weinstock-Guttman B, Zivadinov R, Horakova, D, Havrdova, E, Qu, J, Shyh, G, Lakota, E, O‘Connor, K, Badgett, D, Tamano-Blanco, M, Tyblova, M, Hussein, S, Bergsland, N, Willis, L, Krasensky, J, Vaneckova, M, Seidl, Z, Ramanathan M, Carl, E. Lipid profiles are associated with lesion formation over 24 months in interferon-b treated patients following the first demyelinating event.. JNNP. 2013; 84.
- Lo CY, Antonopoulos A, Gupta R, Qu J, Dell A, Haslam SM, Neelamegham S.. Competition between core-2 GlcNAc transferase and ST6GalNAc transferase regulates the synthesis of the leukocyte selectin-ligand on human P-selectin glycoprotein ligand-1 J Biol Chem.. 2013.
- Fisk JC; Li J; Wang H; Aletta JM; Qu J; Read LK. Proteomic analysis reveals diverse classes of arginine methylproteins in mitochondria of trypanosomes. Mol. Cell. Proteomics. 2013; 12.
- Horakova D; Hussein S; Willis L; Krasensky J; Vaneckova M; Seidl Z; Lelkova P; Dwyer MG; Zhang M; Yu H; Duan X; Zivadinov R; Kalincik T; Ramanathan M; Weinstock-Guttman B; Havrdova E; Qu J; TamaAño-Blanco M; Badgett D; Tyblova M; Bergsland N. Environmental Factors Associated with Disease Progression After the First Demyelinating Event: Results from the Multi-Center SET Study. PLOS One. 2013; 8.
- Tu C; Li J; Bu Y; Hangauer D; Qu J. An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization of the cellular responses to novel anti-cancer agents in a prostate cell model. J Proteomics. 2012; 77.
- Jackson CA; Yadav N; Min S; Li J; Milliman EJ; Qu J; Chen Y; Yu MC. Proteomic analysis of interactors for yeast protein arginine methyltransferase Hmt1 reveals novel substrate and insights into additional biological roles. Proteomics. 2012.
- Duan X; Dai L; Chen S; Balthasar JP; Qu J. Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis. Journal of Chromatography A. 2012; 1251.
- Jamesdaniel S; Coling DE; Hinduja S; Ding D; Li J; Cassidy L; Seigel G; Qu J; Salvi R. Cisplatin-induced Ototoxicity Is Mediated by Nitroxidative Modification of Cochlear Proteins Characterized by Nitration of Lmo4. J Biol Chem. 2012; 287.
- Duan X; Abuqayyas L; Dai L; Balthasar JP; Qu J. High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrometry.. Anal Chem. 2012.
- Krishnatry AS, Kamei T, Wang H, Qu J, Fung HL. Identification of nitroglycerin-induced cysteine modifications of pro-matrix metalloproteinase-9 Rapid Commun Mass Spectrom. 2011.
- Tu C, Li J, Young R, Page BJ, Engler F, Halfon MS, Canty JM Jr, Qu J. Combinatorial peptide ligand library treatment followed by a dual-enzyme, dual-activation approach on a nanoflow liquid chromatography/orbitrap/electron transfer dissociation system for comprehensive analysis of swine plasma proteome.. Analytical Chemistry. 2011; 83(12).
- Zimmer S; M. McEvoy S; Li J; Qu J; Read L. A Novel Member of the RNase D Exoribonuclease Family Functions in Mitochondrial Guide RNA Metabolism in Trypanosoma brucei. J Biol Chem.. 2011; 286.
- Weinstock-Guttman B; Willis L; Heininen-Brown M; Ramanathan M; Zivadinov R; Qu J; Cookfair D; Duan X; Bang E; Bergsland N; Hussein S; Cherneva M. Vitamin D metabolites are associated with clinical and mri outcomes in multiple sclerosis patients. J Neurol Neurosurg Psychiatry. 2011; 82.
- Duan x; Engler F; Qu J. Electron transfer dissociation coupled to an Orbitrap analyzer may promise a straightforward and accurate sequencing of disulfide-bridged cyclic peptides: a case study.. J Mass Spectrom. 2010; 45.
- song w; Wang Y; Yu Z; . Rivera Vera C; Qu J; Lin Q. A metabolic alkene reporter for spatiotemporally controlled imaging of newly synthesized proteins in Mammalian cells.. ACS Chem Biol.. 2010; 5.
- Qu J; Lesse AJ; Brauer AL; Cao J; Gill SR; Murphy TF. Proteomic expression profiling of Haemophilus influenzae grown in pooled human sputum from adults with chronic obstructive pulmonary disease reveal antioxidant and stress responses. BMC Microbiology. 2010; 10.
- Duan X, Weinstock-Guttman B, Wang H, Bang E, Li J, Ramanathan M, Qu J. Ultrasensitive quantification of serum vitamin D metabolites using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry. Anal Chem. 2010; 82(6).
- Weinstock-Guttman B; Willis L; Heinnen-Brown M; Ramanathan M; Zivadinov R; Qu J; Cookfair D; Duan X; Bang E; Bergsland N; Hussein S; Cherneva M. Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients. Journal of Neurology Neurosurgery Psychiatry. 2010; 82.
- Cao J; Gonzalez-Covarrubias V; Straubinger RM; Wang H; Duan X; Yu H; Qu J; Blanco JG. A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application for accurate and sensitive quantification of carbonyl reductases in human liver. Analyt. Chem.. 2010; 82.
- Lee M; Koria P; Qu J; Andreadis S. JNK phosphorylates á-catenin and regulates adherens junctions. The FASEB Journal. 2009; 23.
- Vagin VV; Wohlschlegel J; Qu J; Jonsson Z; Huang X; Chuma S; Girard A; Sachidanandam R; Hannon GJ. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction withTudor family members. GENES & DEVELOPMENT. 2009; 23.
- Duan XT; Young R; Straubinger RM; Page BJ; Cao J; Wang H; Yu H; Canty JM; Qu J. A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled to long gradient nano-LC separation and Oribtrap mass spectrometry for the label-free expression profiling of swine heart mitochondria proteome. J. Proteome Res.. 2009; 8.
- Wang H; Straubinger RM; Aletta JM; Cau J; Duan XT; Yu H; Qu J. Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. J Am Soc Mass Spectrom. 2009; 20.
- Yu A; Qu J; Felmlee MA; Cao J; Jiang X. Quantitation of human cytochrome P450 2D6 protein with immunoblot and mass spectrometry analysis. Drug Metab Dispos. 2009; 37.
- Gaspar JR; Qu J; Straubinger NL; Straubinger RM. Highly selective and sensitive assay for paclitaxel accumulation by tumor cells based on selective solid phase extraction and micro-flow liquid chromatography coupled to mass spectrometry.. Analyst. 2008; 133.
- Yu H; Straubinger RM; Cao J; Wang HS; Qu J. Ultra-sensitive quantification of paclitaxel using selective solid-phase extraction in conjunction with reversed-phase capillary liquid chromatography/tandem mass spectrometry. J. Chromatog. A. 2008; 1210.
- Song W, Wang Y, Qu J, Lin Q. Selective functionalization of a genetically encoded alkene-containing protein via "photoclick chemistry" in bacterial cells. J Am Chem Soc. 2008; 130(30).
- Song W, Wang Y, Qu J, Madden MM, Lin Q. A photoinducible 1,3-dipolar cycloaddition reaction for rapid, selective modification of tetrazole-containing proteins. Angew Chem Int Ed Engl. 2008; 47(15).
- Song W; Wang Y; Madden MM; Lin Q; Qu J. A photoinducible 1,3-dipolar cycloaddition reaction for rapid, selective modification of tetrazole-containing proteins. Angew Chem Int Ed Engl. 2008; 47.
- Straubinger RM; Krzyzanski W; Francoforte CM; Qu J. Applications of quantitative pharmacodynamic effect markers in drug target identification and therapy development.. Anticancer Res.. 2007; 27.
- Qu J; Qu Y; Straubinger RM. Ultra-sensitive quantification of corticosteroids in plasma samples using selective solid-phase extraction and reversed-phase capillary high-performance liquid chromatography/tandem mass spectrometry. 2007; 79.
- Liang Q, Qu J, Luo G, Wang Y. Rapid and reliable determination of illegal adulterant in herbal medicines and dietary supplements by LC/MS/MS. J Pharm Biomed Anal. 2006; 40(2).
- Qu J, Liang Q, Liang Q, Luo G, Wang Y. Screening and identification of glycosides in biological samples using energy-gradientneutral loss scan and liquid chromatography tandem mass spectrometry. Analytical Chemistry. 2004; 76(8).
- Qu J, Wang Y, Luo G, Wu Z, Yang C. Validated quantitation of 22 underivatized amino acids in human blood samplesby volatile ion-pair reversed-phase liquid chromatography coupled to isotope dilution tandem mass spectrometry. Analytical Chemistry. 2002; 74(9).
- Qu J, Chen W, Luo G, Wang Y, Xiao S, Ling Z, Chen G. Rapid determination of underivatized pyroglutamic acid, glutamic acid, glutamine and other relevant amino acids in fermentation media by LC-MS-MS. Analyst. 2002; 127(1).
- Qu J, Wang Y, Luo G, Wu Z. Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2001; 928(2).
- Qu J, Wang Y, Luo G. Determination of scutellarin in Erigeron breviscapus extract by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2001; 919(2).
Professional Memberships:
- American Heart Association (2011)
- AAPS (2011)
- American Association of Pharmaceutical Scientists (AAPS) (2011–present)
- Human Proteome Organization (HUPO) (2011–present)
- American Heart Association (AHA) (2011–present)
- International Society of Heart Research (ISHR) (2010–present)
- American Society of Mass Spectrometry (2004)
- American Society for Mass Spectrometry (ASMS) (2004–present)
Presentations:
- "Extensive investigation of ocular tissue disposition of antibody-drug conjugates and the ocular toxicity using novel LC-MS-based strategies" Protein Therapeutics Symposium, Center of Protein Therapeutics Symposium (2019)
- "Sensitive, accurate investigation of biotherapeutics and biomarker/target levels in both fresh and FFPE tissues, and application in Inflammatory bowel diseases" Protein Therapeutics Symposium, Center of Protein Therapeutics Symposium (2019)
- "Novel strategies for global and targeted proteomics" invited seminar, Wake Forest University, Wake Forest University (2019)
- "Towards Highly Sensitive and Accurate Analysis of Novel Biotherapeutics in Tissues" India APA meeting (2019)
- "Novel methods to characterize biotherapeutics and biomarkers in tissues" Beijing Conference and Exhibition on Instrumental Analysis (2018)
- "Characterization of protein therapeutics and targets in tissue" annuval meeting of American Association of Pharmaceutical Scientists, Invited talk (2018)
- "Comprehensive tissue analysis by LC-MS" ThermoFisher User meeting (2018)
- "Comprehensive tissue analysis by LC-MS" ThermoFisher User meeting (2018)
- "Comprehensive tissue analysis by LC-MS" ThermoFisher User meeting (2018)
- "Novel bioanalytical methods to investigate cancer biotherapeutics" annual Applied Pharmaceutical Analysis conference, Invited talk (2018)
- "Highly sensitive investigation of tissue target engagement of biotherapeutics" Delaware Valley Drug Metabolism Discussion symposium (2018)
- "Large-cohort clinical proteomics with IonStar" Department of Transplantation Medicine, Weill Cornell Medical College (2018)
- "Spatially-resolved tissue micro-sampling coupled to sensitive nano-LC-MS to determine the heterogeneous distribution of mAb and targets in tissues" 66th American Society of Mass Spectrometry meeting (2018)
- "IonStar for reliable differential –omics analysis" Invited seminar, Denali Inc (2018)
- "IonStar for robust and practical large-scale proteomics quantification" Invited talk, GSK Inc (2018)
- "Ultra-sensitive and specific LC-MS-based quantification of biotherapeutics without antibody enrichment" European Bioanalytical Forum 2017 (2017)
- "Investigation of mAb therapeutics with sub 1 ng/mL sensitivity by antibody-free LC-MS" 20th Annual Symposium on Clinical & Pharmaceutical Solutions through Analysis (2017)
- "IonStar: solution for high-quality, large-scale proteomic investigation" Thermofisher Scientific user meeting, Invited talk (2017)
- "An IonStar proteomics technique enabling in-depth and comprehensive understanding of biological and pharmaceutical system" Departmental seminar, Dept. of Microbiology, Dental School of SUNY-Buffalo (2017)
- "Towards reliable and accurate LC-MS analysis of mAb therapeutics in tissues" Roche RPF(Roche Postdoc Fellowship Program) symposium talk, La-Roche (2017)
- "Ionstar: extensive and reproducible proteomic measurements in large biological cohorts with high accuracy, precision and extremely-low levels of missing data" International Association for Analytical Proteomics (2017)
- "Ultra-High-Field Orbitrap for reliable Large-scale, Accurate and Extensive Proteomics Quantification" International Association for Analytical Proteomics, workshop (2017)
- "Important considerations for LC/MS-based analysis of Tissue Distributions of Therapeutic Monoclonal Antibody" 65th American Society of Mass Spectrometry meeting, conference talk (2017)
- "Sate-of-the-art in LC/MS-based in vivo investigation of ADC: why it is a much better alternative?" Sino-American Pharmaceutical Professionals Association/China Bioanalytical Forum joint annual meeting (2017)
- "Sensitive, accurate analysis of protein drugs and biomarkers using narrow-window-isolation SRM MS" 65th American Society of Mass Spectrometry meeting, Thermo Fisher, Breakfast workshop (2017)
- "Current status Duo in protein biotherapeutics analysis by LC-MS" invited symposium talk, Sanofi Inc (2017)
- "Quantitative proteomics in cancer research" Departmental Seminar, Roswell Park Cancer Institute, Buffalo (2017)
- "IonStar: A promising alternative to MS2-DIA" Annual US Human Proteome Organization Conference, invited lightening talk (2017)
- "Label-free quantitative strategies in large scale proteomics" Annual Pittcon Conference, Invited talk (2017)
- "LC/MS quantification of mAb therapeutics" ThermoFisher Scientific User Regional Meeting, ThermoFisher Scientific (2017)
- "Unambiguous and comprehensive profiling of adenocarcinoma and stromal proteomes in patient-derived xenograft models: for mechanistic studies and personalized medicine" Annual US Human Proteome Organization Conference, Invited Cancer Moonshot talk (2017)
- "Key considerations for LC/MS-based investigation of biotherapeutics tissue distribution" Invited seminar series talk, Amgen Inc. (2017)
- "Global proteins with high reliability, accuracy and precision" EAS annual meeting (2016)
- "High-resolution MS1 approach for selective and sensitive quantification of large cohorts: less label, more free" invited talk, ThermoFisher Scientifics (2016)
- "IonStar: a promising alternative to SWATH for large-scale protein quantification" Invited seminar (sponsored by ThermoFisher Scientifics), ThermoFisher Scientifics (2016)
- "LC/MS characterization of biotherapeutics" Invited Seminar, Amgen Inc, Amgen Inc (2016)
- "Extensive and Reproducible Proteomic Measurements in Large Biological Cohorts with High Accuracy, Precision and Low Levels of Missing data" 2016 Mass Spectrometry Symposium, University of Rochester (2016)
- "A promising alternative to SWATH:MS1-based strategy(IonStar) enables in-depth and reproducible proteomics quantification in large cohorts with high accuracy and extremely-low-level-missing-data" 64th American Society for Mass Spectrometry Annual Meeting (2016)
- "A Trapping micro-LC/MS strategy for ultra-sensitive, robust and high-throughput quantification of biotherapeutics and biomarkers in complex matrices" 64th American Society for Mass Spectrometry Annual Meeting (2016)
- "Global and targeted protein quantification" 64th American Society for Mass Spectrometry Annual Meeting (2016)
- "Use of reagent-free LC/MS for sensitive analysis of biotherapeutics" Boehringer-Ingelheim Protein Analysis Symposium (2016)
- "LC/MS for global and targeted protein analysis" invited seminar talk, Dept. Chemistry, SUNY-Buffalo (2016)
- "In-depth and Reproducible Proteomic Measurement in Large Pharmaceutical and Clinical Cohorts with High Accuracy and Low Missing Value" invited talk, Dept. Pharmaceutical Sciences, U. Wisconsin (2016)
- "label free quantification with low missing data and high accuracy" 2016 Annual Conference for Association of Biomolecular Resource Facilities, Association of Biomolecular Resource Facilities (2016)
- "LC/MS quantification of low-abundance proteins: is this real? Are we there yet?" Invited Webinar talk, Chinese Association of Analytical Techniques (2015)
- "LC/MS, a promising alternative for biotherpeutics analysis" invited talk, Bristol-Myers Squibb (2015)
- "A Promising Alternative to SWATH for Biomarker Discovery: An Ion-Current Based Approach for Large-Scale, Accurate and Extensive Proteomic Quantification with Extremely Low Level of Missing Data" 2015 Eastern Analytical Symposium (2015)
- "Challenges and strategies for quantitative characterization of biotherapeutics" 5th Pharmaceutical Analysis Conference (2015)
- "Clinical and pharmaceutical proteomics: are we there yet?" invited seminar, Department of Chemistry, Tsinghua University (2015)
- "Investigation of protein drugs by LC/MS: how to deal with the complexity and sensitivity issues" invited speaker, Department of Medicine, Tongji Medical School (2015)
- "LC/MS analysis of proteins and peptides by LC/MS" 2015 Eastern Analytical Symposium (2015)
- "Ultra-Sensitive and Accurate Analysis of Biotherapeutics Using Low-Flow LC/MS" 2015 Eastern Analytical Symposium, Eastern Analytical Symposium (2015)
- "A novel method for reproducible measurement of proteins in large-scale investigation" invited seminar, Dept. of Biology, University of Vermont (2015)
- "A promising alternative to SWATH: an Ion-current-based strategy with extensive proteomic coverage and extremely low level of missing data" BCEIA conference 2015 (2015)
- "Competing risk factor of heart failure vs. sudden cardiac arrest by proteomics" HUPO Human Proteome Organization World Congress, Human Proteome Organization World Congress (2015)
- "The gaps between biomarker candidates and clinical biomarkers" 2015 Euromedlab Annual meeting, The International Federation of Clinical Chemistry and Laboratory Medicine (2015)
- "low flow LC/MS for biotherapeutics analysis" Abbvie Inc. meeting, Abbvie Inc. (2015)
- "Analysis of protein drugs with LC/MS" Abbvie Inc. meeting, Abbvie Inc. (2015)
- "Proteomics for unbiased neurological investigation" SUNY Brain Network of Excellence Workshop, SUNY (2014)
- "Bioanalysis of proteins and peptides by LC/MS" 2014 Eastern Analytical Syposium, 2014 Eastern Analytical Syposium (2014)
- "LC/MS analysis of therapeutic proteins and peptides" 2014 Conference of American Association of Pharmaceutical Scientists, ASMS (2014)
- "Large-Scale Pre-Clinical/Clinical Profiling”" HUPO Human Proteome Organization World Congress, Human Proteome Organization (2014)
- "Retinal proteome profiling for ROP using high-end LC/MS" NIH RPDP meeting (2014)
- "Highly Sensitive Quantification of Bio-therapeutics Using Nano- and Micro-LC/MS" AB SCIEX Worldwide Webinar Series, AB SCIEX (2014)
- "Clinical and Pharmaceutical Proteomics: Global and Targeted" Buffalo Pharmaceutics Symposium (2014)
- "Drastically improved sensitivity and robustness for quantification of therapeutic mAb in tissue and application in PK studies at therapeutically-relevant dosing levels" Center of Protein Therapeutics Symposium (2014)
- "Multiplexed quantification of antigen-antibody complex, free antibody and antigen in plasma and application in PK of CEA and an anti-CEA mAb (T84.66) in a xenograft tumor model" Center of Protein Therapeutics Symposium (2014)
- "High-throughput proteomics analysis for retinopathy" NIH Webinar, NIH Webinar (2014)
- "Characterization of biotherapetuics using cutting-edge LC/MS techniques" Janssen Pharmaceutical, Janssen Pharmaceutical (2014)
- "Towards the sensitive and accurate analysis of biotherapeutic with Low-flow LC/MS" Roche Pharmaceutical, global, Roche Pharmaceutical (2013)
- "Towards a Highly Sensitive and Accurate Characterization of Therapeutic mAb in Plasma and Tissues using Low-flow LC/MS" 2013 Conference of American Association of Pharmaceutical Scientists (2013)
- "Towards the highly sensitive and accurate quantification of mAbs" Fifth Annual Symposium, Center for Protein Therapeutics (2013)
- "Towards the highly sensitive and accurate quantification of mAbs" Center of Protein Therapeutics Symposium (2013)
- "Use of LC-MS to measure Biotherapeutics in biological samples" 2nd BioTx ADME Workshop, Cosponsored with AAPS (2013)
- "Does first year MRI and clinical activity correlate with long term clinical response to glatiramer acetate in multiple sclerosis patients" American Academy of Neurology, American Academy of Neurology (2013)
- "Proteome-level Pharmacokinetic/Pharmacodynamic Analysis of Corticosteroid-responsive Proteins in Rat Liver" 2012 AAPS Annual Meeting and Exposition, AAPS (2012)
- "An innovative dual-enzyme and dual-activation strategy for comprehensive and accurate characterization of protein arginine-methylation in Trypanosoma brucei" HUPO 2012 11th Annual World Congress, HUPO (2012)
- "Clinical investigation of potential biomarkers for innate HIV-1 virus control in long-term-non-progressing patients using a comprehensive and reproducible ion-current-based proteomic expression profiling" HUPO 2012 11th Annual World Congress, HUPO (2012)
- "Comparative proteomic analysis of isolated colon cancer cells from multiple patients using a comprehensive ion current based approach" HUPO 2012 11th Annual World Congress, HUPO (2012)
- "Differential proteomic profiling of bronchoalveolar lavage fluid (BALF) for biomarker discovery in COPD" HUPO 2012 11th Annual World Congress, HUPO (2012)
- "Extensive, proteome-level investigation of the corticosteroid pharmacodynamics with 12 time points using a reproducible and comprehensive ion-current-based profiling strategy" HUPO 2012 11th Annual World Congress, HUPO (2012)
- "Investigation of the action mechanisms of new anti-carcinoma agents via high-resolution, comparative analysis of the drug-responsive proteomic signatures" HUPO 2012 11th Annual World Congress, HUPO (2012)
- "MS1-based quantification: a promising strategy for large-cohort analysis" The European Bioinformatics Institute symposium, invited seminar (2012)
- "Ultra-sensitive biomarker investigation and comprehensive proteomics profiling of drug-responsive proteins using low-flow LC/MS" XenoBiotic Laboratories, XenoBiotic Laboratories (2012)
- "Biomarker discovery in chronic obstructive pulmonary disease: comparative proteome analysis of bronchoalveolar-lavage-fluid using a comprehensive and reproducible ion-current-based method" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
- "Characterization of the Kinetics of Therapeutic Antibody Immune Complexes In Vivo Using Blue Native Electrophoresis and Targeted Nano-LC/MS Analysis" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
- "Extensive, Proteome-Level Investigation of the Corticosteroid Pharmacodynamics with 12 Time Points Using a Reproducible and Comprehensive Ion-Current-Based Profiling Strategy" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
- "Identification of Novel HIV-invasion-markers by Comparing Long-term-non-progressor vs. Normal-progressors among HIV-infected patients using comprehensive and reproducible ion-current-based proteomic expression profiling" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
- "Ultrasensitive, high-throughput and Robust Quantification of monoclonal antibodies in tissues and plasma using a novel Trapping-micro-LC/MS strategy and OAO optimization" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
- "accelerated Method Development for Sensitive, Accurate and Reproducible Quantification of Therapeutic Monoclonal Antibodies in Various Tissues Using Orthogonal-array-optimization and Nano-LC/SRM-MS" 2011 American Society for Mass Spectrometry annual meeting (2011)
- "An innovative dual-enzyme and dual-activation strategy for comprehensive and accurate characterization of protein arginine-methylation in Trypanosoma brucei." 2011 American Society for Mass Spectrometry annual meeting (2011)
- "An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization anti-cancer agents in a prostate cell model" 2011 American Society for Mass Spectrometry annual meeting, ASMS (2011)
- "An ion-overfilling approach that significantly improves the sensitivity of Orbitrap and application in highly sensitive and accurate proteomic profiling" 2011 American Society for Mass Spectrometry annual meeting (2011)
- "An ion-overfilling approach that significantly improves the sensitivity of Orbitrap and application in highly sensitive and accurate proteomic profiling" 2011 American Society for Mass Spectrometry annual meeting (2011)
- "Investigation of the effect of cocaine use and withdrawal in rat models using comprehensive and reproducible ion-current-based proteomic expression profiling" 2011 American Society for Mass Spectrometry annual meeting (2011)
- "Large-scale comparative proteomic analysis of isolated colon cancer cells from multiple patients using a comprehensive and reproducible ion-current-based method" 2011 American Society for Mass Spectrometry annual meeting (2011)
- "Molecular-level elucidation of the anti-carcinoma mechanisms of new agents via high-resolution, comparative analysis of the drug-responsive proteomic signatures" 2011 American Society for Mass Spectrometry annual meeting (2011)
- "Retina Proteome Profiling in a Rat Model of Smith-Lemli-Opitz Syndrome Using a comprehensive, precise and reproducible Ion-current-Based Method" 2011 American Society for Mass Spectrometry annual meeting (2011)
- "Cutting edge LC/MS-based method for investigation of Ophthalmological proteome" (2011)
- "Accurate quantification and validation of therapeutic macromolecules" "The Delaware Valley DRUG METABOLISM DISCUSSION GROUP Symposium" (2010)
- "Targeted investigation of mAB by nano-LC/MS/MS" (2010)
- "Ultra-sensitive quantification of therapeutic proteins" Buffalo Pharmaceutical Syposium (2010)
- "A comprehensive analysis of Swine Plasma Proteome Using Combinatorial Peptide Ligand Libraries (CPLL), Dual-Enzyme Digestion and Dual-Activation sequencing with LTQ/Orbitrap/ETD" 2011 American Society for Mass Spectrometry annual meeting (2010)
- "A high resolution, highly reproducible and sensitive nano_LC configuration that is particularly suitable for large-scale label-free expression profiling" 2010 American Society for Mass Spectrometry annual meeting (2010)
- "A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application in clinical analysis" 2010 ASMS Anuual Meeting (2010)
- "A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application in clinical analysis" 2010 ASMS Anuual Meeting (2010)
- "Exploring Cyclic Peptide Fragmentation by Electron Transfer Dissociation Coupled to Orbitrap Mass Spectrometry" 2010 American Society for Mass Spectrometry annual meeting (2010)
- "Vitamin D and cognitive impairment in multiple sclerosis (MS)" American Academy of Neurology (2010)
- "Vitamin D metabolites are linked to clinical and MRI outcomes in multiple sclerosis patients" American Academy of Neurology (2010)
- "Photoaffinity labeling studies to better define the mechanism of action for Phase II oncology drug KX2-391 (KX01)" 239th National ACS Meeting, San Francisco, CA, March 22, 2010 (2010)
- "Identification Of Cysteine Residues In ALDH2 Responsible" Experimental Biology 2009, FASEB (2009)
- "High-resolution MS1 approach for selective and sensitive quantification of large cohorts: less label, more free" invited talk at Broad Institute by MIT-Harvard, ThermoFisher Scientifics
Service Activities:
- Pharmacy Practice, School of Pharmacy Curriculum Committee; Member (2011)
- Evaluation of tenure and promotion case for Roswell Park Cancer Institute; Evaluation of tenure and promotion case for Roswell Park Cancer Institute; Committee Member (2019)
- Evaluation of tenure and promotion case; Evaluation of tenure and promotion case for University of Rochester; Other (2017)
- Session organizer and chair; Session organizer and chair: US Human Proteome Organization; Chair (2017)
- Chair; Chair, Committee on Career and Professional Development, Chinese American Association of Mass Spectrometry (2107-); Chair (2017–present)
- Session Chair; Session Chair: Eastern Analytical Symposium (2016)
- Grant reviewing panel; Grant reviewing panel: Hong Kong Research Grants Council: Collaborative Grants Scheme; Grant Reviewer (2016)
- UB Faculty Senate; 2016-present UB Faculty Senate; Senator (2016–present)
- Grant reviewing panel; Grant reviewing panel: NASA Human Exploration Research Opportunities Omics grants; Grant Reviewer (2015–2016)
- Committee organizer; Committee organizer for Early Career Competition, HUMAN PROTEOME ORGANIZATION; Committee Member (2015)
- Session organizer; Session organizer of the American Society of Mass Spectrometry 2015 conference; Other (2015)
- Committee; 2015-present Committee for selection of applicants to NSF-Major Research Instrumentation Program of UB; Committee Member (2015–present)
- Co-Organizer; Co-Organizer of the Clinical Day, HUMAN PROTEOME ORGANIZATION 2014; Committee Member (2014)
- Reviewer; Reviewer for Buffalo IMPACT grants; Reviewer (2014)
- Chair; 2012–2013 Chair of Departmental Seminar Series; Chair (2012–2013)
- Abstract reviewer and oral session co-organizer; Abstract reviewer and oral session co-organizer, 2012 American Society for Mass Spectrometry (ASMS) Meeting; Reviewer (2012)
- Committee member; 2012 Committee member for the recruitment of research assistant professor (Department of Pharmaceutical Sciences); Committee Member (2012)
- Runing the proteomics and pharmaceutical analysis facility; Assist and provide expertise and resource to the faculty member in PHC and other departments for proteomic analysis and pharmaceutical analysis. collaborated with >20 groups.; Other (2009)
- Journal peer-review activities; Analytical Chemistry, Circulation Research, Journal of Chromatography A, Journal of Chromatography B, Journal of Separation Sciences, Journal of Proteomics, Proteomics, Journal of Pharmaceutical and Biomedical Analysis, Journal of Proteome Research, Journal of American Society for Mass Spectrometry, Journal of the American College of Cardiology, American Association of Pharmaceutical Science Journal, Rapid Communications in Mass Spectrometry, Journal of Proteomics, Molecular Vision, Nature Nanotechnology, Nature Method, Nature Biotechnology, Nature Communications, Scientific Reports .; Peer Reviewer (2005–present)
- Running the COE proteomics core facility; Other