A special edition of the Journal of Pharmaceutical Sciences was recently dedicated to William Jusko, PhD, SUNY Distinguished Professor, pharmaceutical sciences. The edition honors and recognizes his long-term contributions to the advancement of the pharmaceutical sciences, including his work in the evolution of PK-PD modeling, and his 40-year leadership of significant advances in theoretical and applied pharmacometrics. These advances have provided a foundational framework for the study and understanding of drug exposure-response relationships.