Marilyn E. Morris PhD
Marilyn E. Morris
PhD
Professional Summary:
Research interests are focused in the area of drug transporters and their role in the pharmacokinetics/pharmacodynamics (PK/PD) of drugs. Studies also focus on drug transporters as therapeutic targets. Current research projects:
1. Gamma-hydroxybutyric acid (GHB) Toxicokinetics and Toxicodynamics. GHB is a drug of abuse, known as a "club drug". We are characterizing the mechanisms underlying the toxicokinetics and toxicodynamics of GHB, and evaluating methods to treat overdoses of GHB. For these studies, we are characterizing transport of GHB by Monocarboxylic Acid Transporters (MCTs), transport proteins that determine the absorption, renal clearance, and distribution of GHB throughout the body, including its distribution to the brain, the site of action. Our goal is to devise treatment strategies to treat overdoses of GHB, in order to save lives.
2. Membrane Transporters in Breast Cancer. Drug resistance is the main cause for therapeutic failure and death in breast cancer. My laboratory is interested in the discovery of new classes of compounds useful in reversing multidrug resistance (MDR) to cancer chemotherapeutic agents. One of the main causes of MDR in cancers is due to the overexpression of the efflux transport proteins, P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Our current studies are evaluating various dietary components, organic isothiocyanates and flavonoids, for their effects on BCRP-mediated transport and on the efficacy and toxicity of chemotherapeutic agents.
We are currently examining a new drug target in breast cancer, monocarboxylate transporters.
Education and Training:
- Postdoctoral Fellowship, University of Toronto (1985)
- PhD, State University of New York at Buffalo (1984)
- MS, University of Ottawa (1976)
- Pharmacy Residency Program, Ottawa General Hospital (1974)
- BS, University of Manitoba (1973)
Employment:
- Professor and Chair (2017-present)
- Professor, University at Buffalo, SUNY, University at Buffalo, SUNY (2001-present)
- SUNY Distinguished Professor
- Vice Chair of Specialist Practice, Pharmaceutical Sciences, University at Buffalo, SUNY (2014–2016)
- Associate Dean, The Graduate School, University at Buffalo, SUNY (2006–2012)
- Associate Professor, Pharmaceutical Sciences, University at Buffalo, SUNY (1991–2001)
- Assistant Professor, Pharmaceuitcal Sciences, University at Buffalo, SUNY (1985–1991)
- Lecturer/ Assistant Professor (Pharmacy), Dalhousie University, Dalhousie University, Canada (1976–1978)
- Clinical pharmacist, Pharmacy, Children's Hospital of Eastern Ontario, Canada (1975–1976)
Awards and Honors:
- AAPS Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolsim (2016)
- SUNY Distinguished Professor (2016)
- Innovation in Biotechnology Award, National Biotechnology Conference (2015)
- UB Distinguished Professor, University at Buffalo (2014)
- Alumni of Distinction Award, Faculty of Pharmacy, University of Manitoba (2013)
- Elected Fellow, American Association for the Advancement of Science (2013)
- UB Distinguished Postdoctoral Mentor Award (2012)
- Service Award, from the Pharmacokinetics, Pharmacodynamics and Drug Metabolism Section (2010)
- Pharmacy Leadership Society Faculty Service Award, Beta Omicron Chapter, University at Buffalo (2010)
- Nomination for Teacher of the Year (2009)
- Chancellor's Award for Excellence in Scholarship and Creative Activities (2006)
- Faculty in Leadership (2005)
- Francis Dudley Meyer Award for Breast Cancer Research (2005)
- Elected Fellow, American Association of Pharmaceutical Scientists (2003)
- National Science Foundation POWRE Award (1999)
- National Science Foundation Career Development Award (1996)
- Dr. Nuala McGann Drescher Award (1990)
- Merck Faculty Development Award (1986)
- Medical Research Council of Canada Fellowship (1984)
- Buffalo Pharmaceutics Graduate Scholar (1983)
- Presidential Graduate School Fellowship (1978)
- Medical Research Council of Canada Studentship (1975)
- Medical Research Council of Canada Studentship (1974)
- Canadian Foundation for the Advancement of Pharmacy Scholarship (1974)
- University Gold Medal in Pharmacy (1973)
- Manitoba Pharmaceutical Association Silver Medal (1973)
- Centennial Scholar (1972)
Research Expertise:
- Membrane Transport: The role of drug transporters in pharmacokinetics and pharmacodynamics. Membrane transporters as therapeutic targets
- Pharmacokinetics/Pharmacodynamics
Grants and Sponsored Research:
- February 2018–February 2019
University at Buffalo IMPACT Award
SUNY Research Foundation
Role: Principal Investigator
$35,000 - February 2018–February 2019
University at Buffalo IMPACT Award
SUNY Research Foundation
Role: Principal Investigator
$35,000 - February 2016–January 2018
PhRMA Graduate Fellowship
Pharmaceutical Manufacturers Assoc.
Role: Principal Investigator
$40,000 - September 2012–July 2017
Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies
NIDA
Role: Principal Investigator - July 2015–June 2017
Diversity Supplement: Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies
NIDA
Role: Principal Investigator
$44,000 - January 2016–January 2017
Monocarboxylate Transporters in GHB Disposition
Jazz Pharmaceuticals, Inc.
Role: Principal Investigator - March 2012–December 2016
IMSD: Initiative for Maximizing Student Development: Enabling Access to Cutting-Edge Biomedical and Behavioral Research
NIH/NIGMS
Role: Co-Investigator - September 2015–August 2016
Role of FcRn, megalin and cubilin in the renal clearance and catabolism of IgG in diabetes mellitus/diabetic nephropathy
UB Center for Protein Therapeutics (Balthasar)
Role: Principal Investigator - September 2015–August 2016
Megalin/Cubilin in the Renal Processing of Peptides and Proteins
UB Center for Protein Therapeutics (Balthasar)
Role: Principal Investigator - September 2014–August 2016
Evaluation of mAb Brain Disposition in Alzheimer’s Disease
Center for Protein Therapeutics
Role: Principal Investigator - June 2013–June 2016
iSEED Institute of Strategic Enhancement of Educational Diversity
University at Buffalo
Role: Contributor - September 2014–August 2015
Effect of Type II Diabetes Mellitus and Chronic Kidney Disease on Antibody Pharmacokinetics and Subcutaneous Bioavailability
Center for Protein Therapeutics
Role: Principal Investigator
Patents:
- High Throughput Spectrofluormetric Screen for Drug Binding to Human Serum P Type: Regular (2001)
Journal Articles:
- Jones RS, Morris ME. Monocarboxylate Transporters: Therapeutic targets and prognostic factors in disease. Clin Pharmacol Ther. 2016; 100(5).
- Dave RA Morris ME. Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and L-lactate in rats. J Pharmacokinet Pharmacodyn.. 2015; 42(5).
- Guan X, Bryniarski MA, Morris ME. In Vitro and In Vivo Efficacy of the Monocarboxylate Transporter 1 Inhibitor AR-C155858 in the Murine 4T1 Breast Cancer Tumor Model. AAPS J. 2018; 21(1).
- Guan X, Ruszaj D, Morris ME. Development and validation of a liquid chromatography tandem mass spectrometry assay for AZD3965 in mouse plasma and tumor tissue: Application to pharmacokinetic and breast tumor xenograft studies. J Pharm Biomed Anal. 2018; 155.
- Follman KE, Morris ME. Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study. Drug Metab Dispos. 2018; 46(5).
- Follman KE, Dave RA, Morris ME. Effects of renal impairment on transporter-mediated renal reabsorption of drugs and renal drug-drug interactions: A simulation-based study. Biopharm Drug Dispos. 2018; 39(4).
- Bryniarski MA, Yee BM, Jaffri I, Chaves LD, Yu JA, Guan X, Ghavam N, Yacoub R, Morris ME. Increased Megalin Expression in Early Type 2 Diabetes: Role of Insulin Signaling Pathways. Am J Physiol Renal Physiol. 2018.
- Felmlee MA, Morse BL, Follman KE, Morris ME. The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution. AAPS J. 2017; 20(1).
- Morris ME, Rodriguez-Cruz V, Felmlee MA. SLC and ABC Transporters: Expression, Localization, and Species Differences at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers. AAPS J. 2017.
- Morse BL, Chadha GS, Felmlee MA, Follman KE, Morris ME. Effect of chronic γ-hydroxybutyrate (GHB) administration on GHB toxicokinetics and GHB-induced respiratory depression. Am J Drug Alcohol Abuse. 2017.
- Dave RA, Follman KE, Morris ME. γ-Hydroxybutyric Acid (GHB) Pharmacokinetics and Pharmacodynamics: Semi-Mechanistic and Physiologically Relevant PK/PD Model. AAPS J. 2017.
- Jones RS, Parker MD, Morris ME. Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017; 14(9).
- Dave RA, Morris ME. Novel high/low solubility classification methods for new molecular entities. Int J Pharm. 2016; 511(1).
- Dave RA, Morris ME. A quantitative threshold for high/low extent of urinary excretion of compounds in humans. Biopharm Drug Dispos. 2016; 37(5).
- Chadha GS Morris ME. An Extended Minimal Physiologically Based Pharmacokinetic Model: Evaluation of Type II Diabetes Mellitus and Diabetic Nephropathy on Human IgG Pharmacokinetics in Rats. AAPS J. 2015; 17(6).
- Chadha GS Morris ME. Effect of Type 2 Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability in the Rat. AAPS J. 2015; 17(4).
- Vijay N, Morse BL, Morris ME. A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for ?-Hydroxybutyric Acid Overdose. Pharm Res. 2015; 32(6).
- Dave RA, Morris ME. Quantitative structure-pharmacokinetic relationships for the prediction of renal clearance in humans. Drug Metab Dispos. 2015; 43(1).
- Vijay N, Morris ME. Effect of 3,4-methylenedioxymethamphetamine on the toxicokinetics and sedative effects of the drug of abuse, ?-hydroxybutyric acid. J Pharm Sci. 2014; 103(10).
- An G, Wang X, Morris ME. Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport. Drug Metab Dispos. 2014; 42(9).
- Morse BL, Vijay N, Morris ME. Mechanistic modeling of monocarboxylate transporter-mediated toxicokinetic/toxicodynamic interactions between ?-hydroxybutyrate and L-lactate. AAPS J. 2014; 16(4).
- Morris ME, Dave RA. Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J. 2014; 16(4).
- Vijay N, Morris ME. Role of monocarboxylate transporters in drug delivery to the brain. Curr Pharm Des. 2014; 20(10).
- Morse BL, Morris ME. Toxicokinetics/Toxicodynamics of ?-hydroxybutyrate-ethanol intoxication: evaluation of potential treatment strategies. J Pharmacol Exp Ther. 2013; 346(3).
- Roiko SA; Vijay N; Felmlee MA; Morris ME. Brain extracellular ?-hydroxybutyrate concentrations are decreased by L-lactate in rats: role in the treatment of overdoses.. Pharm Res. 2013; 30.
- Aras U; Gandhi YA; Masso-Welch PA; Morris ME. Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in an N-methyl nitrosourea-induced breast cancer animal model. Biopharm Drug Dispos. 2013; 34.
- Morse BL; Morris ME. Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of ?-hydroxybutyrate and ?-butyrolactone.. J Pharmacol Exp Ther. 2013; 345.
- Felmlee MA; Dave RA; Morris ME. Mechanistic models describing active renal reabsorption and secretion: a simulation-based study.. AAPS J. 2013; 15.
- Richter WF, Bhansali SG, Morris ME. Mechanistic determinants of biotherapeutics absorption following SC administration. AAPS J. 2012; 14(3).
- Morse BL, Vijay N, Morris ME. ?-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptor-transporter inhibition therapy for treatment in GHB overdose. Mol Pharmacol. 2012; 82(2).
- Wu F; Tamhane M; Morris ME. Pharmacokinetics, lymph node uptake, and mechanistic PK model of near-infrared dye-labeled bevacizumab after IV and SC administrationi n mice. AAPS J. 2012; 14.
- Gandhi YA, Morris ME. Reevaluation of a quantitative structure pharmacokinetic model for biliary excretion in rats. Drug Metab Dispos. 2012; 40(7).
- An G, Morris ME. A physiologically based pharmacokinetic model of mitoxantrone in mice and scale-up to humans: a semi-mechanistic model incorporating DNA and protein binding. AAPS J. 2012; 14(2).
- An G; Morris ME. A physiologically based pharmacokinetic model of mitoxantrpone in mice and scale-up to humans: a semi-mechanistic model incorporating DNA and protein binding. AAPS J. 2012; 14.
- Roiko SA; Felmlee MA; Morris ME. Brain uptake of the drug of abuse gamma-hyroxybutyric acid in rats. Drug Metab Disp. 2012; 40.
- Wu F; Bhansali SG; Law WC; Bergey EJ; Prasad PN; Morris ME. Fluorescence imaging of the lymph node uptake of proteins in mice after subcutaneous injection: molecular weight dependence. Pharm Res. 2012; E-pub.
- Morse BL; Vijay N; Morris ME. Gamma-hydroxybutyrate (GHB)-induced respiratory depression:Combined receptor-transporter inhibition therapy for treatment of GHB overdoses. Mol Pharmacol. 2012; 2012.
- Morse BL; Felmlee MA; Morris ME. Gamma-hydroxybutyrate blood/plasma opartitioning:effect of physiologic pH on transport by monocarboxylate transporters. Drug Metab Disp. 2012; 40.
- Bhansali SG; Balu-Iyer SV; Morris ME. Influence of route of administration and liposomal encapsulation on blood and lymph node exposure to the protein VEGF-C156S. J Pharm Sci. 2012; 10.
- Morris ME; Yang X; Gandhi YA; Bhansali SG; Benincosa LJ. Interspecies scaling: prediction of human biliary clearance and comparison with QSPKR. Biopharm Drug Dispos. 2012; 33.
- Richter WF; Bhansali SG; Morris ME. Mechanistic determinants of biotherapeutics absorption following SC administration. AAPS J. 2012; 2012.
- Gandhi YA; Morris ME. Re-evaluation of a quantitative structure pharmacokinetic model for biliary excretion in rats. Drug Metab Dispos. 2012; 2012.
- Moon YJ; Brazeau DA; Morris ME. Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells.. Evidence-based Complementary and Alternative Medicine. 2012; 2011.
- Felmlee MA, Morris ME, Mager DE. Mechanism-based pharmacodynamic modeling. Methods Mol Biol. 2012; 929.
- Morris ME, Yang X, Gandhi YA, Bhansali SG, Benincosa LJ. Interspecies scaling: prediction of human biliary clearance and comparison with QSPKR. Biopharm Drug Dispos. 2012; 33(1).
- An G, Morris ME. The sulfated conjugate of biochanin A is a substrate of breast cancer resistant protein (ABCG2). Biopharm Drug Dispos. 2011; 32(8).
- Morris ME; Morse BL; Baciewicz GL; Tessena MM; Acquisto NM; Hutchinson DJ; DiCenzo R. Monocarboxylate Transporter Inhibition with Osmotic Diuresis Increases ?-Hydroxybutyrate Renal Elimination in Humans: A Proof-of-Concept Study. J Clin Toxicol. 2011; 1.
- An G; Wu F; Morris ME. 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice. Pharm Res. 2011; 28.
- Telang U; Morris ME. Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.. Molecular Nutrition Food Research. 2011; 54.
- Tsiklauri L; An G; Ruszaj DM; Alaniya M; Kemertelidze E; Morris ME. Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectroscopy.. J Pharm Biomed Anal.. 2011; 55.
- An G; Gallegos J; Morris ME. The Bioflavonoid Kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated Quercetin Efflux. Drug Metab Disp. 2011; 39.
- Felmlee MA; Krzyzanski W; Morse BL; Morris ME. Use of a Local Sensitivity Analysis to Inform Study Design Based on a Mechanistic Toxicokinetic Model for ?-Hydroxybutyric Acid. AAPS J.. 2011; 13.
- An G, Gallegos J, Morris ME. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metab Dispos. 2011; 39(3).
- Telang U, Morris ME. Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats. Mol Nutr Food Res. 2010; 54(12).
- Syed Alwi SS; Cavell BE; Telang U; Morris ME; Parry BM; Packham G. In vivo modulation of 4E-BP1 phosphorylation by watercress: a pilot study. Brit J Nutr. 2010; 104.
- An G; Morris ME. Effects of the Isoflavonoid Biochanin A on the Transport of Mitoxantrone In Vitro and In Vivo. Biopharm Drug Dispos. 2010; 31.
- Syed Alwi SS, Cavell BE, Telang U, Morris ME, Parry BM, Packham G. In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study. Br J Nutr. 2010; 104(9).
- Moon YJ, Brazeau DA, Morris ME. Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells. Evid Based Complement Alternat Med. 2010; 2011.
- Felmlee MA, Wang Q, Cui D, Roiko SA, Morris ME. Mechanistic toxicokinetic model for gamma-hydroxybutyric acid: inhibition of active renal reabsorption as a potential therapeutic strategy. AAPS J. 2010; 12(3).
- An G, Morris ME. Effects of the isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo. Biopharm Drug Dispos. 2010; 31(5-6).
- Felmlee MA, Roiko SA, Morse BL, Morris ME. Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid. J Pharmacol Exp Ther. 2010; 333(3).
- Yang X, Morris ME. Pharmacokinetics and biliary excretion of mitoxantrone in rats. J Pharm Sci. 2010; 99(5).
- An G; Ruszaj DM; Morris ME. Interference of a sulfate conjugate in quantitative liquid chromatography/tandem mass spectrometry through in-source dissociation Rapid Commun Mass Spectrom. 2010; 24.
- Yang X; Morris ME. Pharmacokinetics and biliary excretion of mitoxantrone in rats. J Pharm Sci. 2010; 99.
- Yang X; Gandhi YA; Morris ME. Biliary excretion in dogs: Evidence for a molecular weight threshold.. Eur J Pharm Sci.. 2010; 40.
- An G; Morris ME. Effects of single and multiple flavonoids on BCRP-mediated accumulation, cytotoxicity and transport of mitoxantrone in vitro. Pharm Res. 2010; Apr 6.
- Felmlee MA; Roiko SA; Morse BL; Morris ME. Concentration-effect relationships for the drug of abuse ?-hydroxybutric acid. J Pharmacol Exp Ther. 2010; Mar 9.
- Lam WK, Felmlee MA, Morris ME. Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells. Drug Metab Dispos. 2010; 38(3).
- An G; Morris ME. HPLC Analysis of Mitoxantrone in Mouse Plasma and Tissues: Application in a Pharmacokinetic Study. Journal of Pharmaceutical and Biomedical Analysis. 2010; 51.
- Zhang S, Sagawa K, Arnold RD, Tseng E, Wang X, Morris ME. Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo. J Pharm Sci. 2010; 99(1).
- Telang U, Ji Y, Morris ME. ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions. Biopharm Drug Dispos. 2009; 30(7).
- Gandhi YA, Morris ME. Structure-activity relationships and quantitative structure-activity relationships for breast cancer resistance protein (ABCG2). AAPS J. 2009; 11(3).
- Yang X, Gandhi YA, Duignan DB, Morris ME. Prediction of biliary excretion in rats and humans using molecular weight and quantitative structure-pharmacokinetic relationships. AAPS J. 2009; 11(3).
- Yang X; Gandhi YA; Duignan DB; Morris ME. Prediction of Biliary Excretion in Rats and Humans Using. AAPS Journal. 2009; Jul 1.
- Gandhi YA; Morris ME. Quantitative structure-activity relationships for breast cancer resistance protein (ABCG2). AAPS Journal. 2009.
- Telang U; Ji Y; Morris ME. ABC transporters and isothiocyanates: Potential for pharmacokinetic diet-drug interactions. Biopharm Drug Disp. 2009; 30.
- Cui D, Morris ME. The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition. Drug Metab Dispos. 2009; 37(7).
- Zhang S; Sagawa K; Arnold RD; Tseng E; Wang X; Morris ME. Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: In vitro and in vivo. J Pharm Sci. 2009.
- Pan Y; Morris ME; Yu A. MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells. Mol Pharmacol. 2009; 75.
- Cui D; Morris ME. The Drug of Abuse {gamma}-Hydroxybutyrate is a Substrate for SMCT1 (SLC5A8): Characterization of SMCT-mediated Uptake and Inhibition.. Drug Metab Disp. 2009; 37.
- Telang U; Brazeau DA; Morris ME. Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.. Exp Biol Med. 2009; 234.
- Lam WK; Felmlee MA; Morris ME. Monocarboxylate Transporter (MCT)-mediated transport of {gamma}- hydroxybutyric acid in human intestinal Caco-2 cells.. Drug Metab Dispos.. 2009; 38.
- Wang Q; Wang X; Morris ME. Effects of L-lactate and D-mannitol on gamma-hydroxybutyrate toxicokinetics and toxicodynamics in rats.. Drug Metab Disp. 2008; 36.
- Pang KS; Morris ME; Sun H. Formed and preformed metabolites: facts and comparisons.. J Pharm Pharmacol. 2008; 60.
- Wang X; Morris ME. Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats. J Pharm Sci.. 2008; 97.
- Wang X, Morris ME. Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats. J Pharm Sci. 2008; 97(10).
- Moon YJ, Shin BS, An G, Morris ME. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008; 25(9).
- Moon YJ; Shin BS; An G; Morris ME. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008; 25.
- Felmlee MA; Morris ME. Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J. 2008; 10.
- Moon YJ; Wang L; DiCenzo R; Morris ME. Quercetin pharmacokinetics in humans. Biopharm Drug Dispos. 2008; 29.
- Wang X; Wang Q; Morris ME. Pharmacokinetic interaction between the flavonoid luteolin and gamma-hydroxybutyrate in rats: potential involvement of monocarboxylate transporters. AAPS J. 2008; 10.
- Moon YJ; Morris ME. Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Mol Pharm. 2007; 4.
- Moon YJ; Zhang S; Morris ME. Real-time quantitative polymerase chain reaction for BCRP, MDR1, and MRP1 mRNA levels in lymphocytes and monocytes. Acta Haematol. 2007; 118.
- Wang Q; Morris ME. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. Drug Metab Dispos. 2007; 35.
- Wang Q; Lu Y; Morris ME. Monocarboxylate transporter (MCT) mediates the transport of gamma-hydroxybutyrate in human kidney HK-2 cells. Pharm Res. 2007; 24.
- Moon YJ, Zhang S, Brazeau DA, Morris ME. Effects of the flavonoid biochanin A on gene expression in primary human hepatocytes and human intestinal cells. Mol Nutr Food Res. 2007; 51(3).
- Wang Q, Morris ME. Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. Drug Metab Dispos. 2007; 35(2).
- Wang X, Morris ME. Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos. 2007; 35(2).
- Moon YJ; Brazeau DA; Morris ME. Effects of flavonoids genistein and biochanin a on gene expression and their metabolism in human mammary cells. Nutr Cancer. 2007; 57.
- Moon YJ, Sagawa K, Frederick K, Zhang S, Morris ME. Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats. AAPS J. 2006; 8(3).
- Morris ME, Zhang S. Flavonoid-drug interactions: effects of flavonoids on ABC transporters. Life Sci. 2006; 78(18).
- Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro. 2006; 20(2).
- Zhou XF, Wang Q, Coburn RA, Morris ME. A high-performance liquid chromatographic method for determination of the niguldipine analogue DHP-014. Biomed Chromatogr. 2006; 20(1).
- Zhou XF, Shao Q, Coburn RA, Morris ME. Quantitative structure-activity relationship and quantitative structure-pharmacokinetics relationship of 1,4-dihydropyridines and pyridines as multidrug resistance modulators. Pharm Res. 2005; 22(12).
- Hu K, Morris ME. Pharmacokinetics of alpha-naphthyl isothiocyanate in rats. J Pharm Sci. 2005; 94(11).
- Zhou XF, Macdiarmid J, Coburn RA, Morris ME. Pharmacokinetics and bioavailability of a newly synthesized dihydropyridine compound with multidrug resistance reversal activity. Biopharm Drug Dispos. 2005; 26(7).
- Ji Y, Kuo Y, Morris ME. Pharmacokinetics of dietary phenethyl isothiocyanate in rats. Pharm Res. 2005; 22(10).
- Ji Y, Morris ME. Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein). Mol Pharm. 2005; 2(5).
- Ji Y, Morris ME. Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein. Biochem Pharmacol. 2005; 70(4).
- Zhang S, Yang X, Coburn RA, Morris ME. Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein. Biochem Pharmacol. 2005; 70(4).
- Wang L, Morris ME. Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2005; 821(2).
- Morris ME, Hu K, Wang Q. Renal clearance of gamma-hydroxybutyric acid in rats: increasing renal elimination as a detoxification strategy. J Pharmacol Exp Ther. 2005; 313(3).
- Zhang S, Wang X, Sagawa K, Morris ME. Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice. Drug Metab Dispos. 2005; 33(3).
- Tseng E, Scott-Ramsay EA, Morris ME. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp Biol Med (Maywood). 2004; 229(8).
- Zhang S, Yang X, Morris ME. Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. Pharm Res. 2004; 21(7).
- Zhang S, Yang X, Morris ME. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol. 2004; 65(5).
- Ji Y, Morris ME. Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry. Anal Biochem. 2003; 323(1).
- Kamath AV, Darling IM, Morris ME. Choline uptake in human intestinal Caco-2 cells is carrier-mediated. J Nutr. 2003; 133(8).
- Zhang S, Morris ME. Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells. Pharm Res. 2003; 20(8).
- Morris ME, Lee HJ, Predko LM. Gender differences in the membrane transport of endogenous and exogenous compounds. Pharmacol Rev. 2003; 55(2).
- Hu K, Morris ME. Determination of alpha-naphthylisothiocyanate and metabolites alpha-naphthylamine and alpha-naphthylisocyanate in rat plasma and urine by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2003; 788(1).
- Zhang S, Morris ME. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J Pharmacol Exp Ther. 2003; 304(3).
- Nguyen H, Zhang S, Morris ME. Effect of flavonoids on MRP1-mediated transport in Panc-1 cells. J Pharm Sci. 2003; 92(2).
- Tseng E, Kamath A, Morris ME. Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine. Pharm Res. 2002; 19(10).
- Morris ME, Murer H. Molecular mechanisms in renal and intestinal sulfate (re)absorption. J Membr Biol. 2001; 181(1).
- Lee HJ, Sagawa K, Shi W, Murer H, Morris ME. Hormonal regulation of sodium/sulfate co-transport in renal epithelial cells. Proc Soc Exp Biol Med. 2000; 225(1).
- Sagawa K, Darling IM, Murer H, Morris ME. Glucocorticoid-induced alterations of renal sulfate transport. J Pharmacol Exp Ther. 2000; 294(2).
- Parikh HH, McElwain K, Balasubramanian V, Leung W, Wong D, Morris ME, Ramanathan M. A rapid spectrofluorimetric technique for determining drug-serum protein binding suitable for high-throughput screening. Pharm Res. 2000; 17(5).
- Lee HJ, Balasubramanian SV, Murer H, Biber J, Morris ME. Modulation of sulfate renal transport by alterations in cell membrane fluidity.. J Pharm Sci. 1999; 88(10).
- Lee HJ, Balasubramanian SV, Morris ME. Effect of pregnancy, postnatal growth, and gender on renal sulfate transport.. Proc Soc Exp Biol Med. 1999; 221(4).
- Sagawa K, Murer H, Morris ME. Effect of experimentally induced hypothyroidism on sulfate renal transport in rats. Am J Physiol. 1999; 276(1 Pt).
- Sagawa K, Benincosa LJ, Murer H, Morris ME. Ibuprofen-induced changes in sulfate renal transport. J Pharmacol Exp Ther. 1998; 287(3).
- Sagawa K, DuBois DC, Almon RR, Murer H, Morris ME. Cellular mechanisms of renal adaptation of sodium dependent sulfate cotransport to altered dietary sulfate in rats. J Pharmacol Exp Ther. 1998; 287(3).
- Sagawa K, DuBois DC, Han B, Almon RR, Biber J, Murer H, Morris ME. Detection and quantitation of a sodium-dependent sulfate cotransporter (NaSi-1) by sandwich-type enzyme-linked immunosorbent assay. Pflugers Arch. 1998; 437(1).
- Kamath AV, Morris ME. Functional expression of P-glycoprotein in the hepatic canalicular membrane of developing rats. J Pharm Sci. 1998; 87(3).
- Kwon Y, Morris ME. Membrane transport in hepatic clearance of drugs. II: Zonal distribution patterns of concentration-dependent transport and elimination processes. Pharm Res. 1997; 14(6).
- Balasubramanian SV, Straubinger RM, Morris ME. Salicylic acid induces changes in the physical properties of model and native kidney membranes. J Pharm Sci. 1997; 86(2).
- Kwon Y, Lee RD, Morris ME. Hepatic uptake of choline in rat liver basolateral and canalicular membrane vesicle preparations. J Pharmacol Exp Ther. 1996; 279(2).
- Kwon Y, Kamath AV, Morris ME. Inhibitors of P-glycoprotein-mediated daunomycin transport in rat liver canalicular membrane vesicles. J Pharm Sci. 1996; 85(9).
- Hansel SB, Morris ME. Hepatic conjugation/deconjugation cycling pathways. Computer simulations examining the effect of Michaelis-Menten parameters, enzyme distribution patterns, and a diffusional barrier on metabolite disposition. J Pharmacokinet Biopharm. 1996; 24(2).
- Kwon Y, Morris ME. Hepatic membrane transport of organic cations using isolated rat hepatocyte membrane vesicles: structure-transport relationships. Pharm Res. 1995; 12(7).
- Zamlauski-Tucker MJ, Morris ME, Springate JE. Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney. Toxicol Appl Pharmacol. 1994; 129(1).
- Benincosa LJ, Morris ME. Inhibition of sulfate transport in rat kidney membrane vesicle preparations by nonsteroidal antiinflammatory drugs. Drug Metab Dispos. 1993; 21(4).
- Benincosa LJ, Morris ME. Tiaprofenic acid inhibits the renal reabsorption of sulfate in rats. Prostaglandins Leukot Essent Fatty Acids. 1993; 49(1).
- Morris ME. Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnes Res. 1992; 5(4).
- Morris ME, Benincosa LJ. Influence of NSAID-induced inhibition of renal prostaglandin synthesis on inorganic sulfate clearance in rats. Proc Soc Exp Biol Med. 1992; 199(4).
- Darling IM, Morris ME. Sulfate homeostasis. IV. Probenecid-induced alterations of inorganic sulfate in rats. Pharm Res. 1991; 8(3).
- Morris ME, Freer JP, Watson WA. Sulfate homeostasis. III. Effect of chronic naproxen or sulindac treatment on inorganic sulfate disposition in arthritic patients with renal impairment. Pharm Res. 1991; 8(2).
- Morris ME, Hansel SB. High-performance liquid chromatographic analysis of p-nitrophenol and its conjugates in biological samples. J Chromatogr. 1990; 532(2).
- Morris ME. Pharmacokinetics and protein binding of salicylate metabolites in rats. Drug Metab Dispos. 1990; 18(5).
- Morris ME, Darling IM. Magnesium cerebrospinal fluid concentrations and protein binding in magnesium-deficient rats. J Pharm Sci. 1990; 79(5).
- Morris ME, Mansfield IL. Effect of an analgesic dose of aspirin on electrolyte disposition in healthy subjects. J Pharm Sci. 1988; 77(9).
- Morris ME, Levy G. Assay of inorganic sulfate in biologic fluids by nonsuppressed (single-column) ion chromatography. Anal Biochem. 1988; 172(1).
- Morris ME, Yuen V, Tang BK, Pang KS. Competing pathways in drug metabolism. I. Effect of input concentration on the conjugation of gentisamide in the once-through in situ perfused rat liver preparation. J Pharmacol Exp Ther. 1988; 245(2).
- Morris ME, Kwon O, Mansfield IL. Sulfate homeostasis. I. Effect of salicylic acid and its metabolites on inorganic sulfate in rats. J Pharmacol Exp Ther. 1988; 244(3).
- Morris ME, Pang KS. Competition between two enzymes for substrate removal in liver: modulating effects due to substrate recruitment of hepatocyte activity. J Pharmacokinet Biopharm. 1987; 15(5).
- Morris ME, LeRoy S, Sutton SC. Absorption of magnesium from orally administered magnesium sulfate in man. J Toxicol Clin Toxicol. 1987; 25(5).
- Morris ME, Gengo FM, Kinkel WR, Castellani DA, Levy G. Effect of acetaminophen on inorganic sulfate concentrations in human cerebrospinal fluid.. J Pharm Sci. 1986; 75(7).
- Morris ME, Levy G. Pharmacodynamics of the hypnotic effect of salicylamide in rats. J Pharm Sci. 1985; 74(6).
- Morris ME, Levy G. Renal clearance and serum protein binding of acetaminophen and its major conjugates in humans. J Pharm Sci. 1984; 73(8).
- Morris ME, Galinsky RE, Levy G. Depletion of endogenous inorganic sulfate in the mammalian central nervous system by acetaminophen. J Pharm Sci. 1984; 73(6).
- Morris ME, Levy G. Plasma inorganic sulfate concentrations in pregnant women. J Pharm Sci. 1983; 72(6).
- Morris ME, Levy G. Serum concentration and renal excretion by normal adults of inorganic sulfate after acetaminophen, ascorbic acid, or sodium sulfate. Clin Pharmacol Ther. 1983; 33(4).
- Morris ME, Levy G. Absorption of sulfate from orally administered magnesium sulfate in man. J Toxicol Clin Toxicol. 1983; 20(2).
- Morris ME. Intravenous drug incompatibilities. Am J Nurs. 1979; 79(7).
- Parker WA, Morris ME, Shearer CA. Incompatibility of diazepam injection in plastic intravenous bags. Am J Hosp Pharm. 1979; 36(4).
- Morris ME. Compatibility and stability of diazepam injection following dilution with intravenous fluids. Am J Hosp Pharm. 1978; 35(6).
Books and Book Chapters:
- Morris ME, Dave RA, Hill KE.. Monocarboxylate Transporters. 2017.
- Wang X Morris ME. Diet/nutrient Interactions with Drug Transporters. 2014.
- You G. Drug Transporters: Molecular Characterization and Effects on Drug Disposition. Second edition.. 2014.
- Felmlee MA; Morris ME; Mager DE. Mechanism-based pharmacodynamic modeling. Computational Toxicology. 2012; 1.
- Morris ME. Membrane Drug Transporters. Foy's Priciples of Medicinal Chemistry. 2012.
- An G; Morris ME. Herbal Supplement-based Interactions. Enzymatic- and Transporter-Based Drug Drug Interactions: Progress and Future Challenges. 2009.
- You G; Morris ME. Overview of Drug Transporter Families. Drug Transporters: Molecular Characterization and Effects on Drug Disposition. 2007.
Abstracts:
- Jaenecke K; Stewart M; Morris ME; Brazeau DA; Havard PF. A Semi-Quantitative Comparison of P-glycoprotein Protein Expression in Peripheral Blood Mononuclear Cells Between the Maternal and Fetal Compartments. Accepted to the 2009 APhA Annual Meeting, San Antonio TX, April 3rd - 6th, 2009.. 2009 APhA Annual Meeting, San Antonio TX, April 3rd - 6th, 2009.. 2009.
Professional Memberships:
- American Assoc for the Advancement of Science (2012)
- International Society for the Study of Xenobiotics (1990)
- Society for Experimental Biology and Medicine (1987)
- American Association of Colleges of Pharmacy (1987)
- American Society for Pharmacology and Experimental Therapeutics (1987)
- American Association of Pharmaceutical Scientists; Chair of PPDM section (1986)
- American Association for the Advancement of Science
- International Pharmaceutical Federation
- American Society for Pharmacology and Experimental Therapeutics
- American Association of Pharmaceutical Scientists (AAPS)
- United University Professions
- American Association of Colleges of Pharmacy (AACP)
- International Society for the Study of Xenobiotics
Presentations:
- "In vivo development and metabolomics investigation of the role of monocarboxylate transporter 6 (MCT6)" AAPS National Biotechnology Conference, American Association of Pharmaceutical Scientists (2017)
- "Organic anion uptake of GHB at the BBB: incorporation of brain transport in modeling of PK/PD" World Congress in the Pharmaceutical Sciences, International Federation of Pharmacy, Board of Pharmaceutical Sciences, FIP (2017)
- "Plenary Closing Debate, , Stockholm Sweden May 24, 2017" World Congress in the Pharmaceutical Sciences, International Federation of Pharmacy, Board of Pharmaceutical Sciences, (2017)
- "Characterizing the expression of the renal reabsorption proteins megalin and cubilin through the progression of Type 2 diabetes" Experimental Biology Annual Meeting, Experimental Biology (2017)
- "Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration." Copenhagen Workshop on Injectables –Current and future challenges, University of Copenhagen, International (2017)
- "Monocarboxylaye transporter family: Role in drug disposition and disease" Seminar, University at Buffalo, Department of Pharmaceutical Sciences (2016)
- "Work-Life Balance" Presentation to UB Pharmacy Practice Faculty, School of Pharmacy and Pharmaceutical Sciences, Dept of Pharmacy Practice (2016)
- "Pharmaceutical Industry-Academic Research Support and Collaborations: What are the Opportunities?" AAPS Annual Meeting, American Association of Pharmaceutical Scientists, Professional Development Program (2015)
- "Transport Your Renal Clearance: Modeling Approaches to Describe Renal Drug Transport." AAPS Annual Meeting, American Association of Pharmaceutical Scientists, Sunrise Session (2015)
- "Predicting Clinical Parameters: Transporters" Seventeenth Annual Land O’ Lakes Conference on Drug Metabolism/Applied Pharmacokinetics, Factors Influencing the Future of Drug Metabolism and Pharmacokinetics,, Land O’ Lakes Conference, Drug Metabolism/Applied Pharmacokinetics (2015)
- "The Art of Modeling" Seventeenth Annual Land O’ Lakes Conference on Drug Metabolism/Applied Pharmacokinetics Short Course, Land O'Lakes Conference, Drug Metabolism/Applied Pharmacokinetics (2015)
- "Why membership in a professional organization is important for your career" American Association of Bangladeshi Pharmaceutical Scientists Convention, American Association of Bangladeshi Pharmaceutical Scientists, Keynote speech (2015)
- "Effect of Type II Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability" AAPS National Biotechnology Conference- Graduate Student Award, AAPS, National Biotechnology Conference (2015)
- "Effect of Type II Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability" AAPS National Biotechnology Conference, American Association of Pharmaceutical Scientists, National Biotechnology Conference (2015)
- "Finding mentors and supporters – “the how and who" National Biotechnology Conference, AAPS, symposium on Women In Pharmaceutical Sciences – Career Development: Facts, Myths, and Tips (2015)
- "A Novel Mechanistic and Physiologically-Based Population Pharmacokinetic Model Incorporating Monocarboxylate Transporter 1 (MCT1)-Mediated Brain Uptake of γ-hydroxybutyric acid (GHB)." AAPS/International Transporter Consortium Drug (ITC) Transporter in ADME Workshop, American Association of Pharmaceutical Scientists, AAPS Drug Transporter Focus Group/International Drug Transporter Consortium (2015)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" invited seminar speaker, University of Michigan, University of Michigan, School of Pharmacy (2015)
- "Monocarboxylate Transporters (MCT) Expression and Function in Triple Negative Breast Cancer (TNBC) Cell Lines: Potential Cancer Target" AAPS/International Transporter Consortium (ITC) Drug Transporter in ADME Workshop, American Association of Pharmaceutical Scientists, Drug Transporter Focus Group and International Drug Transporter Consortium (2015)
- "Novel Mechanistic Kidney Model Incorporating Physiological Fluid Reabsorption and Transporter-Mediated Renal Reabsorption: A Population Pharmacokinetics Approach." AAPS/International Transporter Consortium (ITC) Drug Transporter in ADME Workshop, American Association of Pharmaceutical Scientists, AAPS Drug Transporter Focus Group and International Transporter Consortium (2015)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Invited seminar speaker, Purdue University, Purdue University, School of Pharmacy (2015)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Invted seminar speaker, University of Indiana, University of Indiana, Clinical Pharmacology department (2015)
- "A Quantitative Structure-Pharmacokinetic Relationship (QSPKR) Approach for the Prediction of Renal Clearance in Humans." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2014)
- "Age and Gender-dependent Expression of Monocarboxylate Transporters" AAPS Annual Meeting, AAPS (2014)
- "Gamma-hydroxybutyric Acid Toxicokinetics are Gender and Species-Dependent" AAPS Annual Meeting, AAPS (2014)
- "MCT1 Expression and Function in the Murine Breast Cancer 4T1 Cell Line: A Potential Cancer Target." AAPS Annual Meeting, AAPS (2014)
- "The LPLS Classification System: Practical and parsimonious decision–rules to guide drug discovery and development of new molecular entities." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2014)
- "Women In Pharmaceutical Sciences – Career Development: Facts, Myths, and Tips" AAPS annual meeting, American Association of Pharmaceutical Scientists (2014)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Sixth annual Pittsburgh’s student chapters research symposium., University at Pittsburgh (2014)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters." Invited speaker, Mercer University, Mercer University, School of Pharmacy (2014)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters." invited speaker University of Toronto, University of Toronto, School of Pharmacy (2014)
- "Graduate Education in the Pharmaceutical Sciences: The Path Forward" Chinese Pharmaceutical Association Annual Meeting, Chinese Pharmaceutical Association (2014)
- "Graduate Education in the Pharmaceutical Sciences: The Path Forward" Sino-American Pharmaceutical Association- Greater Philadelphia, Sino-American Pharmaceutical Association- Greater Philadelphia (2014)
- "Why membership in a professional organization is important to your career." AAPS Student Chapter, Mercer University, Mercer University (2014)
- "Effect of Type II Diabetes Mellitus and Chronic Kidney Disease on Antibody Pharmacokinetics and Subcutaneous Bioavailability." Center for Protein Therapeutics Annual Symposium,, Center for Protein Therapeutics (2014)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" invited speaker, University of Sydney, Sydney Australia, University of Sydney, School of Pharmacy (2014)
- "Why membership in a professional organization is important to your career" Pharmaceutical Sciences World Congress, Student Meeting, Monash University, Melbourne Australia, Pharmaceutical Sciences World Congress, Federation Pharmaceutical Federation (2014)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" invited speaker, University of New England, University of New England, School of Pharmacy (2014)
- "Sim CYP Workshop" Workshop, SimCyp Inc, Certera (2014)
- "Monocarboxylate transporter inhibition: a potential treatment strategy for γ-hydroxybutyric acid and ketamine overdose" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2013)
- "Effect of Type II Diabetes Mellitus on Antibody Pharmacokinetics and Subcutaneous Bioavailability." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2013)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" 2013 Alumni Distinguished Speaker Symposium, School of Pharmacy, University of Manitoba, University of Manitoba, School of Pharmacy (2013)
- "Effect of type II diabetes and chronic kidney disease on antibody pharmacokinetics and subcutaneous bioavailability" Center for Protein Therapeutics Annual Symposium,, Center for Protein Therapeutics (2013)
- "Evaluation of microdialysis to detect proteins in brain extracellular fluid," Center for Protein Therapeutics Annual Symposium, Center for Protein Therapeutics (2013)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Key note speaker, AAPS@China Meeting, Chinese University of Hong Kong, Hong Kong, Chinese University of Hong Kong (2013)
- "Membrane Transporters in Drug Pharmacokinetics/Pharmacodynamics," CLIMB-UP/iSEED Seminar, University at Buffalo, University at Buffalo (2013)
- "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Great Lakes Drug Metabolism Conference May 9-10, 2013, Great Lakes Drug Metabolism Group (2013)
- "Gamma-hydroxybutyrate: Toxicokinetics and Toxicodynamics and Treatment Strategies" Molecular Recognition in Biological Systems and Bioinformatics Symposium., University at Buffalo (2013)
- ". A novel monocarboxylate transporter inhibitor as a potential treatment strategy for ?-hydroxybutyric acid overdose" AAPS Transporter Workshop, AAPS (2013)
- ". Generation and Purification of Recombinant Human OAT1 and OAT3 Fusion Proteins." AAPS Transporter Workshop, AAPS (2013)
- "Transporter-Mediated Drig-Food Interactions:Effect of Flavonoids" First International Conference on Pharma and Food (2012)
- "Dietary Flavonoid Fisetin is a Substrate and Inhibitor of Human Organic Anion Transporter 1 (OAT1)." AAPS Annual Meeting, AAPS (2012)
- "Effect of Monocarboxylate Transporter (MCT) Inhibition on the Oral Toxicokinetics/Toxicodynamics of ?-hydroxybutyrate (GHB) and ?-butyrolactone (GBL)." AAPS Annual Meeting, AAPS (2012)
- "Effects of L-lactate and D-mannitol on GHB toxicokinetics/toxicodynamics." AAPS Annual Meeting 2012, AAPS (2012)
- "Intestinal Transporters: Bioavailability, Interactions and Drug Delivery" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2012)
- "Introduction to Metabolites and Metabolite kinetics" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2012)
- "Monocarboxylate Transporters in Health and Disease: MCTs as therapeutic targets." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2012)
- "Postdoc After Graduate School" National Biotechnology Conference, American Association of Pharmaceutical Scientists (2012)
- "Postdoc: Is this for you?" AAPS Annual Meeting, AAPS (2011)
- "Club drug interactions: Effects of MDMA and ketamine on gamma-hydroxybutyrate PK/PD" AAPS Annual Meeting, AAPS (2011)
- "Gamma-hydroxybutyric acid is a substrate for monocarboxylate transporters in rat blood-brain barrier cells" AAPS Annual Meeting, AAPS (2011)
- "Lymphatic uptake of near infrared dye labeled BSA: Pharmacokinetics and biodistribution studies in SKH-1 mouse model" AAPS Annual Meeting, AAPS (2011)
- "Monocarboxylate Transporter Inhibition with L-lactate Increases the Renal Clearance of ?-Hydroxybutyrate in Humans" AAPS Annual Meeting, AAPS (2011)
- "Respiratory Depression in ?-hydroxybuytate Overdose: Interaction with ethanol and treatment using monocarboxylate transporter inhibition" AAPS Annual meeting, AAPS (2011)
- "Lymphatic uptake of proteins after SC administration in rodents: In vivo fluorescence and PET as imaging tools" National Biotechnology Conference, American Association of Pharmaceutical Scientists (2011)
- "Effects of Ethanol and treatment with L-lactate on GHB-induced respiratory depression." Sigma Xi Graduate Research Conference (2011)
- "Pharmacokinetics and pharmacodynamics of Gamma-hydroxybutyrate" Seminar Program, Department of Pharmacology and Toxicology (2011)
- "A mechanistic pharmacokinetic model for the drug of abuse ?-hydroxybutyrate (GHB) in rats." American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientists (2010)
- "Biliary excretion in animals and humans:Re-evaluation of a molecular weight threshold" American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientistd (2010)
- "Determination of mitoxantrone in mouse plasma and tissues by an improved HPLC assay and its application in a pharmacokinetic study." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2010)
- "Interspecies prediction of human biliary clearance based on studies in rats of multiple animal species." American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientists (2010)
- "Physiological based pharmacokinetic model for vascular endothelial growth factor C156S (VEGF C156S) in mice" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2010)
- "Transport and efflux of quercetin and biochanin A in MDCK cell monolayers-Role of efflux transporters" American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientists (2010)
- "Effects of naturally-occurring breast cancer preventive agents on the metabolism of estradiol in the estrogen-responsive human breast cancer cell line MCF-7" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2010)
- "Transporter-mediated drug-herb and drug-food interactions, Symposium on Problems and Strategies in Herb/Food-Drug Interactions" American Chemical Society Annual Meeting, American Chemical Society (2010)
- "Gamma-hydroxybutyratic acid, A drug of abuse, exhibits tissue specific distribution kinetics." Pharmacology Day, University at Buffalo (2010)
- "Non-invasive real time quantitative imaging of lymphatic uptake of subcutaneously administered albumin in mice" National Biotechnology Conference, American Association of Pharmaceutical Scientists (2010)
- "The bioflavonoid kaempferol inhibits ABCG2-mediated quercetin efflux through competitive inhibition." Pharmacology Day, University at Buffalo (2010)
- "The pharmacokinetics and lymphatic exposure of recombinant human vascular endothelial growth factor VEGF-C156S after iv and sc administration" Pharmacology Day, University at Buffalo (2010)
- "Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies" Seminar Program for Institute on Environmental Health and Science, Institute on Environmental Health and Science, Wayne State University (2010)
- "Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB" North Jersey Drug Metabolism Discussion Group Spring Meeting, American Chemical Society (2010)
- "The bioflavonoid kaempferol inhibits ABCG2-mediated quercetin efflux through competitive inhibition." Academic Celebration of Excellence, University at Buffalo (2010)
- "Intestinal transporters: bioavailability, interactions and drug delivery" International Society for the Study of Xenobiotics (ISSX) Annual Meeting. Short Course on Transporters in Drug Disposition and Elimination, ISSX (2009)
- ". Development of physiological based pharmacokinetic model to predict tissue distribution of Vascular Endothelial Growth Factor C156S" American College of Clinical Pharmacology annual meeting, American College of Clinical Pharmacology (2009)
- "A Mechanistic Clinical Pharmacokinetic Model for Stains Which Are OATP1B1 Substrates and Prediction of Their Drug Interactions with Gemfibrozil" UB-Pfizer Conference (2009)
- "A Mechanistic Pharmacokinetic Model for the Drug of Abuse" UB-Pfizer Conference (2009)
- "Development of physiological based pharmacokinetic model to predict tissue distribution of Vascular Endothelial Growth Factor C156S" UB-Pfizer Conference (2009)
- "Inhibition of monocarboxylate transporters as a potential treatment strategy for ?-hydroxybutyric acid overdose." Pharmacology Day (2009)
- "Toxicokinetics and Toxicodynamics of the drug of abuse gamma-hydroxybutyrate." , University of Georgia (2009)
- "Transport and efflux of quercetin and biochanin A in MDCK cell monolayers -- role of efflux transporters" Pharmacology Day, University at Buffalo (2009)
- "A Semi-Quantitative Comparison of P-glycoprotein Protein Expression in Peripheral Blood Mononuclear Cells Between the Maternal and Fetal Compartments." 2009 APhA Annual Meeting, APhA Annual Meeting (2009)
- "Characterization of sodium dependent monocarboxylate transporter-1 (SMCT1)-mediated GHB transport in FRTL-5 cells" Experimental Biology annual meeting, Federation of Experimental Biology/American Assoc of Pharmacology and Experimental Therapeutics (2009)
- "Monocarboxylate transporter (MCT)-mediated transport of ?-hydroxybutyric acid in human intestinal Caco-2 cells" Experimental Biology Annual Meeting, American Assoc of Pharmacology and Experimental Therapeutics (2009)
- "Non-invasive real time quantitative imaging of lymphatic uptake of subcutaneously administered proteins in mice" Postdoc Research Symposium, Graduate School, University at Buffalo (2009)
- "The Effect of Flavonoids on Transport of Mitoxantrone in ABCG2" Celebration of Excellence, UB (2009)
- "Establishment of an Office of Postdoctoral Scholars at the University at Buffalo, SUNY: Successes and Challenges." National Postdoctoral Association (2009)
- "Postdoc Survival Workshop: Teaching Responsible Conduct of Research" National Postdoctoral Association (2009)
- "A Mechanistic Clinical PK Model for the OATP-mediated Pravastatin and Gemfibrozil Drug Interaction" American Association of Phsrmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
- "Effect of Dietary Phenethyl Isothiocyanate on Tumor Growth in an Animal Model of Estrogen-dependent Breast Cancer" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
- "Effect of multiple flavonoids combinations on breast cancer resistance protein (ABCG2)-mediated transport" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
- "Inhibition of the BCRP-mediated transport of mitoxantrone by the flavonoids kaempferide and biochanin A" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
- "Pharmacokinetic and pharmacodynamic interactions of dietary flavonoids" American Association of Pharmaceutical Scientists Annual Meeting, AAPS (2008)
- "Quantitative structure-activity relationships for the ABCG2-mediated transport of flavonoids" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
- "A career in the pharmaceutical sciences: Unlimited potential" Student Research and Career Day, Departments of Pharmacology and Pharmaceutical Sciences, University of Cincinnati (2008)
- "Dietary flavonoids: Effects on xenobiotic and carcinogen membrane transport and disposition" World Congress of Pharmacy and Pharmaceutical Sciences, FIP Congress (2008)
- "The role of drug transport in accelerating drug discovery/development" Drug Development (MS degree) program, University of Cincinnati (2008)
- "Development and pharmacokinetic evaluation of liposomal VEGF-C156S." Great Lakes Symposium (2008)
- "Formulation and biophysical characterization of liposomes encapsulating VEGF C156S for pharmacokinetic (PK) and pharmacokinetic (PD) studies" National Biotechnology Conference, AAPS (2008)
- "Formulation and biophysical characterization of liposomes encapsulating VEGF-C156S for PK/PD studies." Sigma Xi Research Conference (2008)
- "Formulation and biophysical characterization of liposomes encapsulating VEGF-C156S for PK/PD studies." UB-Pfiszer Conference (2008)
- "Enhancement of mitoxantrone cytotoxicity and transport by flavonoids Biochanin A and Kaempferide, two potent BCRP inhibitors" Sigma Xi research Symposium (2008)
- "Prediction of Biliary Excretion in Rats and Humans Using Quantitative Structure- Pharmacokinetic Relationships." , Pfizer Global Inc. (2008)
Service Activities:
- Dean's Committee on Addictions; Member (2016–2017)
- Searle Grant proposal review for UB; Ad Hoc Reviewer (2016)
- Program Review for School of Pharmacy, Washington State University; Ad Hoc Reviewer (2016)
- APhA Remington Award Review; Ad Hoc Reviewer (2016)
- UB Mentoring Committee; University at Buffalo; Member (2015–present)
- Defense Threat Reduction Agency; grant reviews and progress evaluation; Grant Reviewer (2015)
- National Institute of Child Health and Human Development; NIH contract reviews; Grant Reviewer (2015)
- UB Awards Development Committee; University at Buffalo; Member (2015–present)
- AAPS Awards Review Committee; Grant Reviewer (2015)
- UB Awards Committee; University at Buffalo; Member (2015–present)
- University Deans Advisory Committee; University at Buffalo; Department Representative (2015–present)
- SPPS Teacher of the Year Selection Committee; Department Representative (2014–2016)
- PHC Graduate Awards Committee; Member (2014–present)
- Elected Executive Committee Member, Board of Pharmaceutical Sciences, International Pharmaceutical Federation; Service to the Profession-International; Executive Board (2014–2018)
- AAPS Nominations Committee; Chair-Elect (2014–2015)
- AAPS Past President; Past President (2014–2015)
- Board of Pharmaceutical Sciences, FIP; Executive Board (2014–2018)
- AAPS Research Funding and Resources Committee; American Association of Pharmaceutical Scientists; Member (2014–present)
- Member, Graduate Education committee, American Association of Colleges of Pharmacy; Committee Member (2014–present)
- Defense Threat Reduction Agency grant reviews; Grant Reviewer (2014)
- School of Pharmacy Executive Committee; Member (2014–present)
- Strategic Planning Committee; Chair of Services Subcommittee; Chair (2014)
- AAPS President; elected president of the American Association of Pharmaceutical Scientists; President (2013–2014)
- AAPS Foundation; Executive Board (2013–present)
- Maine Sea Grant Program Reviewer; Grant Reviewer (2013)
- Edward Mallinckrodt Foundation Review Committee, Office of the VP Research, UB; Grant Reviewer (2013)
- NIH Study Section (XNDA) grant reviewer; National Institutes of Health Review submitted NIH grants; Grant Reviewer (2013)
- Advisory Committee member, iSEED program, UB; Executive Board (2013–present)
- Molecular Pharmaceutics Editorial Board; Editorial Board Member (2013–present)
- AAPS President-Elect; American Association of Pharmaceutical Scientists; Executive Board (2012–2013)
- Chair, AAPS Member Group Coordination Committee; Chair (2012–2013)
- Decanal Review Committee; SPPS grievance committee; Chair (2012)
- Honor‘s Program Grant Review Committee; Meet 3 times per year to review funding proposals; Grant Reviewer (2012–present)
- NIH grant reviewer, XNDA; National Institutes of Health reviewed for XNDA section; attended study section meeting; Grant Reviewer (2011)
- AAPS Committee - Electronic Program development committee; AAPS; Member (2011–2013)
- AAPS Student Chapter Advisor; Faculty Liaison (2011–present)
- SoPPS 125th Reunion Committee; To plan the 2011 reunion; Member (2010)
- Accreditation Self-study Committee; I am chairing the Faculty Self-study for accrediation.; Chair (2010–2011)
- Buffalo Pharmaceutics Symposium 2010 Committee; To organize one scientific symposium on Drug Transporters; Coordinator (2010)
- AAPS Executive Committee- Member at Large; American Association of Pharmaceutical Scientists Member of Executive Committee of association; Executive Board (2009–2012)
- PHC Controlled Drugs Committee; To manage the storage, use and licensing for all controlled drugs in the department. Tp approve new applications for use of controlled drugs.; Chair (2009–present)
- AAPS Program Coordination Committee; American Association of Pharmaceutical Scientists Reviewed and approved workshop and webinar applications for the association.; Other (2008–2009)
- Faculty Search Committee, Department of Pharmacology and Toxicology; To review applications, interview candidates ahd hire 6 faculty members in 2 years. 3 faculty have been hired.; Member (2008–2010)
- UB Wellness Committee; To promote wellness at UB by programs, information; Committee Member (2008–2011)
- AAPS J Associate Editor; AAPS Journal; Associate Editor (2008–present)
- Biopharmaceutics and Drug Disposition Editorial Board; Biopharmaceutics and Drug Disposition; Editorial Board Member (2008–present)
- Chair, Pharmacokinetics, Pharmacodynamics and Drug Metabolism section; American Association of Pharmaceutical Scientists Chair of the section, directing programming, awards, and all activities of the section. Implemented an Educational Initiative to support student chapters to invite AAPS fellows to their institution for se; Other (2007)
- Nominations Committee; American Association of Pharmaceutical Scientists Reviewed and recommended nominations for leadership positions; Other (2007)
- UB Environmental Stewartship Committee; To promote environmental sustainability.To produce a compact with plans and procedures to acheive carbon neutrality at UB. I also serve on the subcommittee for Education and Research.; Committee Member (2007–2010)
- FDA Pharmaceutical Sciences and Clinical Pharmacology Advisory Panel; Food and Drug Administration Review specific issues and guidances for the FDA and provide scientific input.; Panel Member (2006–present)
- Graduate School Executive Committee; Propose and discuss graduate school issues, policies and procedures.; Member (2006)
- Associate Dean, Graduate School; As Associate Dean for Graduate and Postdoctoral Education, I head the Office for Postdoctoral Scholars and anm in volved in professional development programs and polices for graduate students and postdoctoral scholars. I also head the Office of Comprehe; Administrator (2006–2012)
- Pharmaceutical Research Editorial Board; Pharmaceutical Research; Editorial Board Member (2005–present)
- Past Chair of the Pharmacokinetics, Pharmacodynamics and Drug Metabolism section; American Association of Pharmaceutical Scientists On executive committee of section.; Chair (2004–2008)
- School of Pharmacy Curriculum Committee; Address curricular issues, making recommendations to the Executive Committee.; Member (2004)
- Clarkson University Parents Advisory Committee; Clarkson University Advised on University issues; involved with orientations, fund raising; Other (2002–2006)
- School of Pharmacy Promotions and Tenure Committee; Review all dossiers for promotion in the School and vote.; Committee Member (2001–present)
- Journal Of Pharmaceutical Sciences Editorial Board; Journal of Pharmaceutical Sciences; Editorial Board Member (1995–present)
- PHC Director of Graduate Studies; Reviewed graduate applicants, graduate program policies and graduate student progress.; Director (1993–2001)
- Outside Reviewer for promotion 2-3 per year; University promotions I generally review at least 2 dossiers a year for promotion, as an outside reviewer.; Peer Reviewer