Associate Dean for Academic Affairs, Associate Professor
Department of Pharmaceutical Sciences
Research interests include:
1. Innovations in pedagogy and educational technologies.
2. Drug transport across the blood-brain barrier. Focuses on the mechanisms of drug transport across the blood-brain and blood-cerebrospinal fluid barriers. Nature designed these barriers to restrict and regulate the entry of blood borne substances into brain tissue. Essential nutrients are transported efficiently by carrier proteins expressed by the blood-brain and blood-cerebrospinal fluid barriers. However, these barriers hinder the entry of many drugs, and typically it is only highly lipophilic drugs that gain access to brain tissue via passive diffusion across the barriers. Consequently, many lead drug candidates are disqualified from further development because of poor permeability across the blood-brain barrier. There is much scientific interest in understanding brain transport processes with the goal of identifying methods, which enhance drug delivery across brain barriers.
3. Neuroinflammatory Brain Diseases. Understanding the role of neuroinflammatory processes in the progression of chronic neurodegenerative diseases. Since inflammatory processes are a common feature of many neurological diseases (viz., Alzheimer‘s disease, multiple sclerosis, HIV-1 dementia,cerebral ischemia, brain tumors and meningitis), an enhanced knowledge of inflammatory mediators and their detrimental effects on the centraln ervous system provides opportunities for the design of new pharmaceutical approaches in the management of neurological diseases.