Research

Based on the cutting-edge LC/MS strategies we developed, we are actively conducting studies in the following categories:

• Proteomics-based biomarker discovery for clinical diagnosis, disease staging/stratification, and understanding drug effects and other biological mechanisms.
• Sensitive identification, localization and quantification of post-translational modifications in clinical and pharmaceutical systems
• Ultra-sensitive quantification of therapeutic proteins (e.g. monoclonal antibodies) for the PK study
• Ultra-sensitive quantification of small-molecule drugs/metabolites/endogenous markers in pharmaceutical systems
• Development of novel analytical methods that provide higher sensitivity, selectivity, throughput and robustness

• 12 LC and MS instruments ($2.5 million in total value)
• Supercomputer systems for analysis of large-scale proteomics data
• Various bioinformatics software packages

We have 1600 square feet of lab space located on both the University at Buffalo South Campus and the Center for Bioinformatics and Life Sciences building downtown. The labs are well-equipped with various liquid chromatography (LC), mass spectrometer (MS) and sample processing instruments, as well as complete sets of biochemistry apparatus.