Grants and Publications

Ebeling MC, Polanco JR, Qu J, Tu C, Montezuma SR, Ferrington DA. Improving retinal mitochondrial function as a treatment for age-related macular degeneration. Redox Biol. 34: 101552. (2020)

An B, Zhang M, Pu J, Qu Y, Shen S, Zhou S, Ferrari L, Vazvaei F, Qu J*. Toward Accurate and Robust Liquid Chromatography-Mass Spectrometry-Based Quantification of Antibody Biotherapeutics in Tissues. Anal Chem. 92(22):15152-15161. (2020)

Santha S, Ling X, Aljahdali IAM, Rasam SS, Wang X, Liao J, Wang J, Fountzilas C, Li Q, Qu J, Li F. Mutant Kras as a Biomarker Plays a Favorable Role in FL118-Induced Apoptosis, Reactive Oxygen Species (ROS) Production and Modulation of Survivin, Mcl-1 and XIAP in Human Bladder Cancer. Cancers (Basel). 12(11):3413. (2020)

Rapanelli M, Tan T, Wang W, Wang X, Wang ZJ, Zhong P, Frick L, Qin L, Ma K, Qu J, Yan Z. Behavioral, circuitry, and molecular aberrations by region-specific deficiency of the high-risk autism gene Cul3. Mol. Psychiatry. 10.1038/s41380-019-0498-x. (2019)

Wang X, Shen S, Rasam SS, Qu J*. MS1 ion current-based quantitative proteomics: A promising solution for reliable analysis of large biological cohorts. Mass Spectrom Rev. 38(6):461-482. (2019)

Zhang J, Gelman IH, Katsuta E, Liang Y, Wang X, Li J, Qu J, Yan L, Takabe K, Hochwald SN. Glucose Drives Growth Factor-Independent Esophageal Cancer Proliferation via Phosphohistidine-Focal Adhesion Kinase Signaling. Cell Mol Gastroenterol Hepatol. 8:37-60. (2019)

Singel KL, Emmons TR, Khan ANH, Mayor PC, Shen S, Wong JT, Morrell K, Eng KH, Mark J, Bankert RB, Matsuzaki J, Koya RC, Blom AM, McLeish KR, Qu J, Ram S, Moysich KB, Abrams SI, Odunsi K, Zsiros E, Segal BH. Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment. JCI Insight. 4: e122311. (2019)

An B, Zhang M, Pu J, Shen S, Qu Y, Chen YJ, Huo S, Wang X, Polli JR, Balthasar JP, Herzog D, Ferrari L, Staack RF, Richter WF, Otteneder MB, Benincosa LJ, Zhou S, Vazvaei F, Qu J*. High-throughput, sensitive LC-MS quantification of biotherapeutics and biomarkers using an antibody-free, peptide-level multiple-mechanism enrichment via strategically regulated pH, ionic and solvent strengths. Anal. Chem. 91:3475-3483. (2019)

Kafková L, Tu C, Pazzo KL, Smith KP, Debler EW, Paul KS, Qu J, Read LK. Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response. MBio. 9: e02430-18. (2018)

Ng AY, Tu C, Shen S, Xu D, Oursler MJ, Qu J*, Yang S. Comparative Characterization of Osteoclasts Derived From Murine Bone Marrow Macrophages and RAW 264.7 Cells Using Quantitative Proteomics. JBMR Plus. 2:328-340. (2018)

Shen S, An B, Wang X, Hilchey SP, Li J, Cao J, Tian Y, Hu C, Jin L, Ng A, Tu C, Qu M, Zand MS, Qu J*.  Surfactant Cocktail-Aided Extraction/Precipitation/On-Pellet Digestion Strategy Enables Efficient and Reproducible Sample Preparation for Large-Scale Quantitative Proteomics. Anal. Chem. 90:10350-10359. (2018)

Shen X, Shen S, Li J, Hu Q, Nie L, Wang X, Poulsen D, Orsburn B, Wang J, Qu J*. IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts. Proc. Natl Acad Sci U.S.A. 115:E4767-E4776. (2018)

Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR. GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. J. Exp. Med. 215:941-961.  (2018)

Zhang M, An B, Qu Y, Shen S, Fu W, Chen Y, Wang X, Young R, Canty, JM, Balthasar JP, Murphy K, Bhattacharyya D, Josephs J, Ferrari L, Zhou S, Bansal S, Vazvaei F, Qu J*. A sensitive, high-throughput and robust Trapping Micro-LC-MS strategy for large-scale quantification of biomarkers and antibody biotherapeutics. Anal. Chem. 90:1870-1880 (2017)

Tian Y, Jacinto MP, Zeng Y, Yu Z, Qu J, Liu WR, Lin Q. Genetically encoded 2-aryl-5-carboxytetrazoles for site-selective protein photo-cross-linking. J. Am. Chem. Soc. 139:6078 (2017)

Qu M, An B, Shen S, Zhang M, Shen X, Duan X, Balthasar JP, Qu J*. Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry. Mass Spectrom. Rev. 21500, (2016)

Yuan X, Cao J, He X, Serra R, Qu J, Cao X, Yang S. Ciliary IFT80 balances canonical versus non-canonical hedgehog signaling for osteoblast differentiation. Nat. Commun. 7:11024 (2016)

Zhang T, Shen S, Qu J, Ghaemmaghami S. Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy. Cell Rep. 14:2426-39 (2016)

Lott K, Mukhopadhyay S, Li J, Wang J, Yao J, Sun Y, Qu J, Read LK. Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome. Nucleic Acids Res. 43:5501-23 (2015)

An B, Zhang M, Johnson RW, Qu J*. Surfactant-Aided Precipitation/on-Pellet-Digestion (SOD) Procedure Provides Robust and Rapid Sample Preparation for Reproducible, Accurate and Sensitive LC/MS Quantification of Therapeutic Protein in Plasma and Tissues. Anal. Chem. 87:4023-9 (2015)

Weinstock-Guttman B, Zivadinov R, Horakova D, Havrdova E, Qu J, Shyh G, Lakota E, O'Connor K, Badgett D, Tamaño-Blanco M, Tyblova M, Hussein S, Bergsland N, Willis L, Krasensky J, Vaneckova M, Seidl Z, Ramanathan M. Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event. J. Neurol. Neurosurg. Psychiatry. 84:1186-91 (2013)

Zivadinov R, Treu CN, Weinstock-Guttman B, Turner C, Bergsland N, O'Connor K, Dwyer MG, Carl E, Ramasamy DP, Qu J, Ramanathan M. Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 84:1075-81(2013)

Weinstock-Guttman B, Zivadinov R, Qu J(co-first author), Cookfair D, Duan X, Bang E, Bergsland N, Hussein S, Cherneva M, Willis L, Heininen-Brown M, Ramanathan M. Vitamin D metabolites are associated with clinical and mri outcomes in multiple sclerosis patients. J. Neurol. Neurosurg. Psychiatry. 82:189-95 (2011)

Vagin V, Wohlschlegel J, Qu J, Jonsson X, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon G. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 23:1749-1762 (2009)

Song W; Wang Y; Qu J; Lin Q. Selective functionalization of a genetically encoded alkene-containing protein via photoclick chemistry in bacterial cells. J. Am. Chem. Soc. 130:9654-5 (2008)