Kathleen M. Tornatore PharmD
Kathleen M. Tornatore
PharmD
Professional Summary:
Research works focuses in the area of Clinical Pharmacokinetic and Pharmacodynamic Research of Immunosuppressive Regimens in Renal Transplantation. This clinical research program has been an ongoing collaborative program with the Division of Nephrology at Erie County Medical Center for over 15 years focusing on the pharmacokinetics, pharmacodynamics and pharmacogenomics of immunosuppressive agents during renal transplantation: Current and upcoming clinical research endeavors focus upon pharmacokinetics of immunosuppressive drugs in relationship to pharmacodynamics of immunologic markers and targeted pharmacogenomic endpoints in relation to race and gender of the renal transplant recipient. Research projects may provide the student with exposure to a variety of biomedical technologies including LCMSMS, flow cytometry and Q-PCR. These projects provide Pharm.D. students with an opportunity to explore clinical and translational research projects though a clinical research team (i.e. Pharm.D.s, physicians, nurse clinicians, immunologists, geneticists, biostatisticians, etc.) by participation in clinical pharmacology sub-studies in renal transplant patients with the endpoint to provide safe and efficacious immuosuppression (e.g. cyclosporine, prednisone, mycophenolic acid) among different patient groups. In addition, this funded clinical research program has focused on the pharmacokinetics and dynamics of glucocorticoids with specific emphasis on the impact of the factors of gender, race, acute rejection, time post-transplant, immunologic response and chronic adverse effects in the renal transplant population. This research program has also evaluated the pharmacodynamics of anti-lymphocyte induction agents as well as glucocorticoid pharmacokinetics during various "steroid withdrawal" protocols during a multi-center clinical trial.
Education and Training:
- Fellowship in Pharmacokinetics, School of Pharmacy; University at Buffalo (1985)
- PharmD, Pharmacotherapeutics & Clinical Pharmacokinetics, The State University of NY at Buffalo (1981)
- BS, Albany College of Pharmacy/Union University, Cum laude (1978)
Employment:
- Professor of Pharmacy Practice, Dean's Office, University at Buffalo (2014-present)
- Research Professor of Medicine, University at Buffalo (2014-present)
- Research Associate Professor of Medicine (2000-present)
- Associate Professor of Pharmacy, University at Buffalo (1995-present)
- Research Associate Professor of Medicine (2000)
- Associate Professor of Pharmacy (1995)
Awards and Honors:
- Fellow, American Society of Transplantation (2015)
- Teacher of the Year Finalist (2013)
- Scholl of Pharmacy and Parmaceutical Sciences Finalist "Teacher of the Year" (2013)
- Cambridge Who's Who Registry among Executives and Professionals (2011)
- 2010 Marquis Who's Who in the World 2011 (28thEdition) (2010)
- Fellow (2008)
- Clinical Researcher of the Year (2005)
- Who’s Who in Medicine & Health (3rd Edition) (2001)
- Educator of the Year by New York State College of Clinical Pharmacy (2001)
- Who's Who in Medicine & Health (3rd Edition) (2000)
- Who's Who of Women in Science & Engineering (1996)
- Who's Who of Women in Science & Engineering (1995)
- Marquis Who's Who of American Women (19th Edition) (1994)
- The World Who's Who of Women (10th Edition) (1990)
- The World Who's Who of Women (8th Edition) (1988)
- International Who's Who of Professional and Business Women (1987)
- Outstanding Young Women of America (1984)
- Achievement Award (1984)
- Dean's List (1978)
- Bigelow Scholarship Award (1978)
- Board of Trustees Honor Scholarship (1978)
- Dean's List (1977)
- Bigelow Scholarship Award (1977)
- Board of Trustees Honor Scholarship (1977)
- Rho Chi Honorary Pharmaceutical Fraternity (1977)
- Dean's List (1976)
- Bigelow Scholarship Award (1976)
- Board of Trustees Honor Scholarship (1976)
Grants and Sponsored Research:
- January 2020–December 2024
University of Buffalo Clinical and Translational Science Institute: Community Engagement Core
NCATS
Role: Co-Investigator
$4,118,079 - January 2020–December 2024
Institutional Career Development (KL2 Mentored Career Development Award)
NCATS
Role: Co-Investigator
$447,382 - June 2015–December 2017
CYP3A5 Genotypes and Relation to Tacrolimus Pharmacokinetics and Adverse Effects: Influence of Race and Sex
Astellas
Role: Principal Investigator
$112,321 - September 2014–January 2016
Influence of Race, Sex and ABCB1 Haplotypes on Tacrolimus (Prograf) Pharmacokinetics and Adverse effects in Stable Renal Transplant Recipients
Astellas Scientific and Medical Affairs, Inc
Role: Co-Investigator
$83,621 - September 2009–August 2011
Genomic and Cellular Markers and Chronic Allograft Function(NIDDK ARRA DK077325-01A1)
NIDDK
Role: Principal Investigator
$434,175
Journal Articles:
- Brazeau D, Meaney CJ, Consiglio JD, Wilding GE, Cooper LM, Venuto RC, Tornatore KM. Association of ABCC2 Haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients. J Clin Pharmacol. 2021.
- Brazeau DA, Attwood K, Meaney CJ, Wilding GE, Consiglio JD, Chang SS, Gundroo A, Venuto RC, Cooper L, Tornatore KM. Beyond Single Nucleotide Polymorphisms: CYP3A5∗3∗6∗7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients. Front Genet. 2020; 11.
- Meaney CJ, Sudchada P, Consiglio JD, Wilding GE, Cooper LM, Venuto RC, Tornatore KM. Influence of Calcineurin Inhibitor and Sex on Mycophenolic Acid Pharmacokinetics and Adverse Effects Post-Renal Transplant. J Clin Pharmacol. 2019; 59(10).
- Mager DE, Brazeau D, Venuto RC, Tornatore KM. The Impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients British Journal of Clinical Pharmacology. 2019; 85(3).
- Campagne O, Mager DE. Population Pharmacokinetics of Tacrolimus in Transplant Recipients: What Did We Learn About Sources of Interdividual Variabilities? American College of Clinical Pharmacology. 2019; 59(3).
- Campagne O, Mager DE, Brazeau D, Venuto RC, Tornatore KM. The Impact of Tacrolimus Exposure on Extrarenal Adverse Effects in Adult Renal Transplant Recipients. British Journal of Clinical Pharmacology. 2018; 85(3).
- Campagne O, Mager DE, Brazeau D, Venuto RC, Tornatore KM. Tacrolimus Population Pharmacokinetics and Multiple CYP3A5 Genotypes in Black and White Renal Transplant Recipients. J Clin Pharmacol. 2018; 58(9).
- Venuto RC, Meaney CJ, Chang S, Leca N, Consiglio JD, Wilding GE, Brazeau D, Gundroo A, Nainani N, Morse SE, Cooper LM, Tornatore KM. Association of Extrarenal Adverse Effects of Posttransplant Immunosuppression With Sex and ABCB1 Haplotypes. Medicine (Baltimore). 2015; 94(37).
- Tornatore KM, Meaney CJ, Wilding GE, Chang SS, Gundroo A, Cooper LM, Gray V, Shin K, Fetterly GJ, Prey J, Clark K, Venuto RC. Influence of Sex and Race on Mycophenolic Acid Pharmacokinetics in Stable African American and Caucasian Renal Transplant Recipients. Clinical Pharmacokinet. 2015; 54(4).
- Meaney CJ, Arabi Z, Venuto RC, Consiglio JD, Wilding GE, Tornatore KM. Validity and Reliability of a Novel Immunosuppressive Adverse Effects Scoring System in Renal Transplant Recipients. BMC Nephrology. 2014; 15.
- Maguire O, Tornatore KM, O‘Loughlin KL, Venuto RC, Minderman H. Nuclear Translocation of Nuclear Factor of Activated T Cells (NFAT) as a Quantitative Pharmacodynamic Parameter for Tacrolimus. Cytometry Part A. 2013; 83(12).
- Tornatore KM, Brazeau D, Dole K, Danison R, Wilding G, Leca N, Gundroo A, Gillis K, Zack J, DiFrancesco R, Venuto RC. Sex Differences in Cyclosporine Pharmacokinetics and ABCB1 Gene Expression in Mononuclear Blood Cells in African-American and Caucasian Renal Transplant Recipients. Journal of Clinical Pharmacology. 2013; 53(10).
- Kumar R; Pendyala P; Sudchada P; Venuto R RC; Gray V; Gundroo A; Attwood K; Tornatore-Morse KM. Comparison of 12-hour creatinine clearance and estimated glomerular filtration rate in renal transplant recipients. Renal Failure. 2013; 35.
- Nainani N, Patel N, Tahir N, Kumar R, Weber-Shrikant E, Gundroo AA, Murray BM, Tornatore KM, Blessios GA, Venuto RC. Effect of Steroid-Free Low Concentration Calcineurin Inhibitor Maintenance Immunosuppression Regimen on Renal Allograft Histopathology and Function. Nephrology Dialysis Transplantation. 2012; 27(5).
- Tornatore KM, Sudchada P, Dole K, Difrancesco R, Leca N, Gundroo AC, Danison RT, Attwood K, Wilding GE, Zack J, Forrest A, Venuto RC, Gundroo AA. Mycophenolic Acid Pharmacokinetics During Maintenance Immunosuppression in African American and Caucasian Renal Transplant Recipients. Journal of Clinical Pharmacology. 2011.
- Damodar A, Mustafa R, Bhatnagar J, Panesar M, Gundroo A, Zachariah M, Blessios G, Tornatore KM, Weber-Shrikant E, Venuto RC.. Use of Anti-CD20 Antibody in the treatment of Post-Transplant Glomerulonephritis. Clinical Transplantation. 2010; 25(3).
- Zachariah MS, Tornatore KM, Venuto RC. Kidney Transplantation and Pregnancy. Current Opinion Organ Transplantation. 2009; 14(4).
- Nainani N; Blessios GA; Venuto RC; Singh N; Damodar A; Parimoo N; Ummadi S; Qazi Y; Murray BM; Tornatore-Morse KM; Ciccirella J. Cross Reactive Epitope Group Antibodies in Sensitized Kidneys Transplant recipients was associated with Early Acute Antibody Mediated Rejection. Transplant Immunology. 2009.
- DiFrancesco R; Frerichs V; Donnelly J; Hagler C; Hochreiter J; Tornatore-Morse KM. Simultaneous Determination of Cortisol, Dexamethasone, Methylprednisolone, Prednisone, Prednisolone, Mycophenolic Acid and Mycophenolic Acid Glucuronide in Human Plasma Utilizing Liquid Chromatography Tandem Mass Spectrometry.. Journal of Chromatography B. 2007.
- Qazi YA, Forrest A, Tornatore KM, Venuto RC. The Clinical Impact of 1:1 Conversion from Neoral to a Generic Cyclosporine (Gengraf) in Renal Transplant Recipients with Stable Graft Function.. Clin Transplant. 2006; 20(3).
- Tornatore KM, Gilliland-Johnson KK, Farooqui M, Reed KA, Venuto RC. Pharmacokinetics and Pharmacodynamic Response of Methylprednisolone in Premenopausalrenal Transplant Recipients. Journal of Clinical Pharmacology. 2004; 44(9).
- Frerichs VA, Tornatore KM. Determination of the glucocorticoids prednisone, prednisolone, dexamethasone, and cortisol in human serum using liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 802(2).
- Tornatore KM, Garey KW, Saigal N, Reed K, Murray BM, Ingalls E, DiFrancesco R, Forrest A, Morse GD, Venuto RC, Morse GD. Ganciclovir Pharmacokinetics and Cytokine Dynamics in Renal Transplant Recipients with Cytomegalovirus Infection.. Clinical Transplantation. 2001; 15(5).
- Tornatore KM, Reed KA, Venuto RC. Assessment of Methylprednisolone Pharmacokinetics and Cortisol Response During the Early and Chronic Postrenal Transplant Periods.. Transplantation. 1995; 60(12).
- Tornatore KM, Reed KA, Venuto RC. Methylprednisolone and cortisol metabolism during the early post-renal transplant period Clinical Transplantation. 1995; 9(6).
- Tornatore KM, Reed K, Venuto R. 24-hour immunologic assessment of CD4 and CD8 lymphocytes in renal transplant recipients receiving chronic methylprednisolone Clin Nephrol. 1995; 44(5).
- Tornatore KM, Biocevich DM, Reed KA, Tousley K, Gray V, Singh JP, Murray BM, Venuto RC. Post-transplant diabetes mellitus and methylprednisolone pharmacokinetics in African-American and Caucasian renal transplant recipients Clinical Transplantation. 1995; 9(4).
- Walshe JJ, Reed K, Venuto RC, Tornatore KM. Pharmacokinetics of Methylprednisolone During Acute Renal Allograft Rejection.. Clinical Transplantation. 1995; 9(2).
- Biocevich DM, Reed K, Tousley K, Singh JP, Venuto RC, Tornatore KM. Methylprednisolone Pharmacokinetics, Cortisol Response, and Adverse Effects in Black and White Renal Transplant Recipients.. Transplantation. 1995; 59(5).
- Reed KA, Venuto RC, Tornatore KM. Repeated Assessment of Methylprednisolone Pharmacokinetics During Chronic Immunosuppression in Renal Transplant Recipients.. Annals of Pharmacotherapy. 1995; 29(2).
- Reed K, Walshe JJ, Venuto RC, Tornatore KM. Cortisol Pharmacodynamic Response to Long-Term Methylprednisolone in Renal Transplant Recipients.. Pharmacotherapy. 1994; 14(1).
- Tornatore KM, Reed K, Venuto RC. CD4+/CD8+ Lymphocyte Patterns in Renal Transplant Recipients Receiving Chronic Methylprednisolone. Journal of Medicine. 1993; 24(2-3).
- Tornatore KM, Morse GD, Jusko WJ, Walshe JJ. Methylprednisolone disposition in renal transplant recipients receiving triple-drug immunosuppression. Transplantation. 1989; 48(6).
- Kanarkowski R, Tornatore KM, D‘Ambrosio R, Gardner MJ, Jusko WJ. Pharmacokinetics of single and multiple doses of ethinyl estradiol and levonorgestrel in relation to smoking. Clin Pharmacol Ther. 1988; 43(1).
- Gardner MJ, Tornatore KM, Jusko WJ, Kanarkowski R. Effects of tobacco smoking and oral contraceptive use on theophylline disposition. Br J Clin Pharmacol. 1983; 16(3).
- Tornatore KM, Kanarkowski R, McCarthy TL, Gardner MJ, Yurchak AM, Jusko WJ. Effect of chronic oral contraceptive steroids on theophylline disposition. Eur J Clin Pharmacol. 1982; 23(2).
Abstracts:
- Tornatore KM, Minderman H, Attwood K, O‘Loughlin K, Venuto RC. P-glycoprotein function: Association with Race, Gender and Tacrolimus Pharmacokinetics.. American Journal of Transplantation. 2016; 16(S3).
- Tornatore KM, Attwood K, McGuire O, O‘Loughlin K, Venuto RC, Minderman H. Nuclear Factor of Activated T-cells Post-Renal Transplant;. American Journal of Transplantation. 2016; 16(S3).
- Tornatore KM, Meaney CJ, Consiglio JD, Wilding G, Chang SS, Venuto RC. Sex And Race Influences on Tacrolimus Pharmacokinetics in Renal Transplant Recipients. J Am Soc Nephrol. 2015; 26(suppl).
- Tornatore KM. Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite. American Transplant Congress. 2019.
- Tornatore KM. Race-Sex Effects on Immune Response Potential during Tacrolimus Minimization Therapy in Stable Renal Allograft Recipients. American Transplant Congress. 2019.
- Tornatore KM, D. Brazeau, C. Meaney, K. Attwood, G. Wilding, Chang, R. Venuto.. Association of CYP3A5*3*6*7 Metabolic Composites to Tacrolimus Pharmacokinetics in African American and Caucasian Renal transplant recipients. American Journal of Transplantation. 2018; 18(S4).
- K. Tornatore, K. Attwood, D. Brazeau, Chang, R. Venuto. Target Tacrolimus Troughs and CYP3A5 Polymorphisms Do Not Predict Therapeutic Drug Exposure in African American and Caucasian Renal Transplant Recipients. American Journal of Transplantation. 2018; 18(S4).
- Tornatore KM, Attwood K, Venuto RC. Age Influences on Tacrolimus Pharmacokinetics Post-transplant. JASN. 2017; 29(Suppl).
- Chen S, Tornatore K, Brazeau D, Warner J, Venuto R. Association of Cytochrome P450 3A4*1beta Genotype and Tacrolimus Pharmacokinetics in Stable African American and Caucasian renal transplant patients. PHARMACOTHERAPY. 2017; 37(12).
- Olivia Campagne, Donald E. Mager, Daniel Brazeau, Rocco C. Venuto, Kathleen M. Tornatore. Tacrolimus Population Pharmacokinectis and CYP3A5 Genotypes in African American and Caucasian Renal transplant recipients. American Society for Clinical Pharmacology and Therapeutics. 2017.
- Tornatore KM, Brazeau D, Wilding GE, Cooper LM, Venuto RC. CYP3A5 Genotype and Race Association to Tacrolimus Pharmacokinetics. J Am Soc Nephrol:. 2016; 27(suppl).
- Tornatore KM, Attwood K, Cooper LM, Venuto, RC. Influence of Age and Race on Mycophenolic Acid Pharmacokinetics Post-transplant. J Am Soc Nephrol. 2016.
- Tornatore KM, Meaney CJ, Wilding GE, Chang SS, Gundroo A, Cooper LM, Gray V, Shin KN, Fetterly GJ, Prey JJ, Clark K, Venuto RC.. Influence Of Sex And Race On Mycophenolic Acid Pharmacokinetics In Stable African American And Caucasian Renal Transplant Recipients. Clinical Pharmacology & Therapeutics. 2016; 99(S1).
- Tornatore KM, Brazeau D, Meaney CJ, Cooper LM, Venuto RC. Sex and ABCB1 Haplotype Associations with Tacrolimus Pharmacokinetics in Renal Transplant Recipients. J Am Soc Nephrol. 2015; 26(suppl).
- Tornatore-Morse KM; Minderman H; Chiang S; O‘Louglin K; Attwood K; Venuto RC. Glycoprotein Function in Peripheral Blood Mononuclear Cells in Renal Transplant Recipients: Sex and Race Influences.. Clinical Pharmacology & Therapeutics. 2013; 92.
- Tornatore-Morse KM; Minderman H; O‘Loughlin K; Attwood K; Venuto RC. Gender and Race influences on P-glycoprotein Function in Peripheral Blood Mononuclear Cells and Relation to Tacrolimus Adverse Effects Post-transplant. American Journal of Transplantation. 2012.
- Tornatore-Morse KM; Minderman H; McGuire O; O‘Loughlin K; Shan G; Wilding G; Venuto RC. Nuclear Localization of Nuclear Factor of Activated T-Cells for Tacrolimus Immunosuppression Post-transplantation. American Journal of Transplantation. 2012.
- Tornatore-Morse KM; Minderman H; McQuire O; O‘Loughlin K; Shan G; Wilding G; Venuto RC. Nuclear Localization of Nuclear Factor of Activated T-cells as a Pharmacodynamic Marker of Tacrolimus Immunosuppression in Renal Transplant Recipients. American Journal of Transplantation. 2012; 12.
- Tornatore-Morse KM; Minderman H; McQuire O; OLouglin K; Shan G; Wilding GE; Venuto RC. Nuclear Localization of Nuclear Factor of Activated T-cells as a Pharmacodynamic Marker of Tacrolimus Immunosuppression in Renal Transplant Recipients. American Journal of Transplantation. 2012; 12.
- Tornatore-Morse KM; Brazeau D; Gundroo A; Gray V; Venuto R. ABCB1 Gene Expression in Peripheral Blood Mononuclear Cells in African American and Caucasian Renal Transplant Recipients. Clinical Pharmacology & Therapeutics. 2012; 91.
- Tornatore-Morse KM; Brazeau D; Gundroo A; Venuto R. Racial Influence on ABCB1 Gene Expression in Peripheral Blood Mononuclear Cells in Stable Renal Transplant Recipients. American Society of Nephrology online. 2011.
- Pendyala P; Suchada P; Venuto R; Gray V; Gundroo A; Attwood K; Wilding G; Tornatore-Morse KM. Comparison of Carefully Measured Creatinine to Clearance (CrCl) to Estimated Glomerular Filtration Rate (eGFR) in Stable Renal Transplant. American Journal of Transplantation. 2010; 10.
- Tornatore-Morse KM; Sudchada P; DiFrancesco R; Gundroo A; Vanessa G; Attwood K; Wilding G; VEnuto R. Mycophenolic Acid and Metabolite Pharmacokinetics in African American (AA) and Caucasian (C) Renal Transplant Recipients receiving Enteric Coated Mycophenolic Sodium and Mycophenolate Mofetil.. American Journal of Transplantation. 2010; 10.
- Tornatore-Morse KM; Suchada P; DeFrancesco R; Gundroo A; Gray V; Attwood K; Wilding G; Venuto R. Time Dependent Pharmacodynamic Responses of T Regulatory Cells in Stable African American and Caucasian Renal Transplant Recipients. Journal of Transplantation. 2010.
- Tornatore-Morse KM; Sudchada P; DiFrancesco R; Gundroo A; Gray V; Attwood K; Wilding G; Venuto RC. Comparison of Mycophenolic Acid Pharmacokinetics in African American and Caucasian Renal Transplant Recipients Receiving Mycophenolate Mofetil and Enteric Coated Mycophenolic Sodium;. Journal of the American Society of Nephrology. 2009.
- Gundroo A; Mustafa R; Tahir N; Tornatore-Morse KM; Venuto R; Wallace P. Early Recovery of Cytomegalovirus (CMV) Specific CD8+ Lymphocytes and Decreased Incidence of CMV Infection in Renal Transplant Recipients Induced with Alemtuzuab (CAM1H). Journal of the American Society of Nephrology. 2009; 4.
- Tornatore-Morse KM; Dole K; DiFrancesco R; Gillis KA; Leca N; Gundroo AA; Venuto RC. Gender Differences in Cyclosporine Pharmacokinetics in Stable African American and Caucasian Renal Allograft Recipients. Amer J Transplant. 2009; 9.
- Tornatore-Morse KM; DiFrancesco R; Suchada P; Gundroo AA; Minderman H; O‘Loughlin K; Wilding GE; Danison R; Venuto RC. Assessment of P-glycoprotein in Peripheral Mononuclear Cells in African American and Caucasian Renal Transplant Recipients During Chronic cyclosporine Therapy. Clin. Pharmacol.Ther. 2009; 85.
- Tornatore-Morse KM; Suchada P; Brazeau DA; Venuto RC. Time Dependent Expression of MRP-2 in Periperhal Mononuclear Cells in African American and Caucasian Renal Transplant Recipients. Clin. Pharmacol.Ther. 2009; 85.
- Tornatore-Morse KM; DiFrancesco R; Suchada P; Gundroo AA; Minderman H; O‘Loughlin K; Wilding GE; Danison R; Venuto RC. Assessment of P-glycoprotein in Peripheral Mononuclear Cells in African American and Caucasian Renal Transplant Recipients During Chronic cyclosporine Therapy. Clin Pharmacol Ther. 2009; 85.
- Tornatore-Morse KM; Suchada P; Brazeau DA; Venuto RC. Time Dependent Expression of MRP-2 in Periperhal Mononuclear Cells in African American and Caucasian Renal Transplant Recipients. Clin Pharmacol Ther. 2009; 85.
- Damodor A; Bhatnagar J; Zachariah M; Tornatore-Morse KM; Weber-Shrikant E; Gundroo AA; Panesar M; Venuto RC. Aggressive Immunosuppression Benefits Post-transplant Glomerulonephritis. Amer J Transplant. 2009; 9.
- Tornatore-Morse KM; Dole K; DiFrancesco R; Gillis KA; Leca N; Gundroo AA; Venuto RC. Gender Differences in Cyclosporine Pharmacokinetics in Stable African American and Caucasian Renal Allograft Recipients. Amer J Transplant. 2009; 9.
- Patel N; Nainani N; Murray BM; Gundroo AA; Blessios G; Tornatore-Morse KM; Venuto RC. Effect of Steroid Avoidance and Low Dose Calcinuerin-Inhibitor Immunosuppression on Progression of Chronic Allograft Nephropathy (CAN) Assessed by Surveillance Biopsy. J Am Soc Nephrol. 2008; 19.
- Nainani N; Patel N; Rahman M; Tahir N; Murray BM; Gundroo AA; Blessios G; Tornatore-Morse KM; Venuto RC. Effect of Steroid Free Mainatenance Immunosuppression Protocol on Progression of Chronic Allograft Nephropathy. Amer J Transplant. 2008; 8.
- Suchada P; Gundroo AA; Donnelly A; DiFrancesco R; Hochreiter J; Venuto RC; Tornatore-Morse KM. Influence of Cyclosporine Exposure on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients. Amer J Transplant. 2008; 8.
- Suchada P; Brazeau DA; Dole K; Venuto RC; Tornatore-Morse KM. Quantitative real-time PCR Analysis of MRP-2 Expression in Peripheral Mononuclear Cells. Clin Pharmacol Ther. 2008; 82.
- Tornatore-Morse KM; Dole K; Zack J; DiFrancesco R; Gillis K; Leca N; Gundroo AA; Venuto RC. Cyclosporine Gender Differences with 12 hour Pharmacokinetic Analysis in Stable Renal Allograft Recipients.. J Am Soc Nephrol. 2007.
- Singh N; Nainani N; Qazi Y; Murray B; Gundroo AA; Blessios G; Tornatore-Morse KM; Venuto RC. Outcomes of Alemtuzumab Induction in High Risk Renal Transplant Recipients.. J Am Soc Nephrol. 2007.
- Tornatore-Morse KM; Brazeau DA; KD; Gillis KA; Lecca N; Yassa S; Venuto RC. Impact of Gender, Race and Time on MDR-1 Gene Expression in Stable Renal Transplant Recipients. Clin. Pharmacol.Ther. 2007; 81.
- Okusanya OO; Dole K; Zack J; Forrest A; Gundroo AA; Lecca N; Venuto RC; Tornatore-Morse KM. Population Pharmacokinetic Model of Mycophenolic Acid and its Metabolite-Mycophenolic Acid Glucuronide in Long Term Renal Transplant Patients using Monte CArlo Parametric Expectation Maximization. Clin. Pharmacol.Ther.. 2007; 81.
- Suchada P; Dole K; Zack J; Lecca N; Gundroo AA; Venuto RC; Tornatore-Morse KM. Influence of Race and Steroid Use on Mycophenolic Acid Pharamcokinetics Post- Renal Transplant. Amer J Transplant. 2007; 7.
- Suchada P; Dole K; Zack J; lecca N; Gundroo AA; Venuto RC; Tornatore-Morse KM. Influence of Steroid Use and Gender on Mycophenolic Acid Pharmacokinetics Post-Renal Transplant.. Amer. J. Transplant.. 2007; 7.
- Singh N; Murray BM; Qazi Y; Hassan M; Khalil F; Blessios G; Tornatore-Morse KM; Venuto RC. Maintenance Steriod Free CAmpath-1H Induction Regimen Reduces Metabolic Complications. Amer J Transplant. 2007; 7.
- Qazi Y; Singh N; Gundroo AA; Khalil F; Hassan M; Murray BM; Blessios G; Tornatore-Morse KM; Venuto RC. One year Results of Alemtuzumab Induction, Calcineurin Minimization Protocol in Renal Transplant Recipients Monitored by Surveillance Biopsies.. Amer J Transplant. 2007; 7.
- Gillis KA, Quazi Q, Karam J, Blessios G, Tornatore KM, Venuto RC. Serial Pharmacodynamic Responses to Anti-Lymphocyte Globulin. Pharmacotherapy. 2006; 19.
Professional Memberships:
- AST Community of Practice for Basic & Translational Sciences; Liaison (2012)
- ACCP Research Institute Funding Liasion to Immunology PRN (2011)
- AST Community of Practice Transplant Pharmacist (2009)
- AST Women's Health Community of Practice (2007)
- American College of Clinical Pharmacy- Program committee; Program coordinator for Complex Drug Interactions (2005)
- American Collecge of Clinical Pharmacy (2001)
- American Society of Nephrology (2001–present)
- American Society of Clinical Pharmacology & Therapeutics (2000)
- ACCP Research Institute Review Panel (1999)
- American Society of Transplant Physicians (1998–present)
- American Society of Clinical Pharmacology and Therapeutics (1995–present)
- American College of Clinical Pharmacy (1994–present)
- American Society of Transplantation (1990)
- American College of Clinical Pharmacy, New York State Chapter (1990–present)
- American Society of Health System Pharmacists (1990–present)
- American Association of Colleges of Pharmacy (1990–present)
- American Association for the Advancement of Science (1990–present)
- American Federation of Aging Research (1990–present)
- International Society for Immunopharmacology (1990–present)
- American Association of Colleges of Pharmacy (1986)
- American Society of Nephrology (1986)
- American Society of Health-System Pharmacy (1980)
Presentations:
- "CYP 3A5 Genotype and Race Association to Tacrolimus Pharmacokinetics" American Society of Nephrology Annual Meeting, American Society of Nephrology, #2845 Abstract (2016)
- "Influence of Age and Race on Mycophenolic Acid Pharmacokinetics Post-transplant" American Society of Nephrology Annual Meeting, American Society of Nephrology, #2851 Abstract (2016)
- "Nuclear Factor of Activated T-cells Post-Renal Transplant;" American Transplant Congress, American Transplant Congress, Presentation #: D235 (2016)
- "P-glycoprotein function: Association with Race, Gender and Tacrolimus Pharmacokinetics" American Transplant Congress, American Transplant Congress, Abstract #: 335 (2016)
- "INFLUENCE OF SEX AND RACE ON MYCOPHENOLIC ACID PHARMACOKINETICS IN STABLE AFRICAN AMERICAN AND CAUCASIAN RENAL TRANSPLANT RECIPIENTS" Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT), Amer Soc Clin Pharmacol & Therapeut, MAR 08-12, 2016 (2016)
- "Sex and ABCB1 Haplotype Associations with Tacrolimus Pharmacokinetics in Renal Transplant Recipients" American Society of Nephrology annual Meeting 2015, American Society of Nephrology, Pharmacokinetics/Pharmacodynamics/ Pharmacogenomics (2015)
- "Sex And Race Influences on Tacrolimus Pharmacokinetics in Renal Transplant Recipients:" American Society of Nephrology annual Meeting 2015;, American Society of Nephrology, Pharmacokinetics/Pharmacodynamics/ Pharmacogenomics (2015)
- "ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant" 2015 American Transplant Congress, American Society of Transplantation, Immunosuppression & Clinical Use (2015)
- "Influence of Race on P-glycoprotein Function in Peripheral Blood Mononuclear Cells" American Transplant Congress 2015, American Society of Transplantation, Immune Monitoring II (2015)
- "Differences in Mycophenolic Acid and Metabolite, Mycophenolic Acid Glucuronide Exposures between Calcineurin Inhibitor Regimens Post-renal Transplant" Annual Meeting of Society of Clinical Pharmacology & Therapeutics, American Society of Clinical Pharmacology & Therapeutics, Pharmacokinetics (2015)
- "Comparison of Mycophenolic Acid Exposure and Gastrointestinal Adverse Effects in Stable Renal Transplant Recipients: Association to Calcineurin Inhibitor Therapy" 2014 Annual Meeting of American Society of Nephrology, Philadelphia, PA, American Society of Nephrology, Pharmacokinetics/Pharmacodynamics, Pharmacogenomics (2014)
- "CYP 3A5 Genotype and Race Association to Tacrolimus Pharmacokinetics" American Society of Nephrology Annual Meeting, American Society of Nephrology, #2845 Abstract (2014)
- "Influences of Sex and Calcineurin inhibitors on Mycophenolic Acid Pharmacokinetics Post Renal Transplant" World Transplant Congress 2014; San Francisco, CA;, American Society of Transplantation, Clinical Immunosuppression (2014)
- "Leukocyte Patterns and Mycophenolic Acid Pharmacokinetics in African American and Caucasian Renal Transplant" World Transplant Congress 2014; San Francisco, CA;, American Society of Transplantation ; Abstract B993, Immunosuppression, Clinical (2014)
- "Influence of ABCC2 Haplotypes and Calcineurin Inhibitors on Mycophenolic Acid in Stable Renal Transplant Recipients" Annual Meeting of Society of Clinical Pharmacology & Therapeutics, Annual Meeting of Society of Clinical Pharmacology & Therapeutics (2014)
- "P-Glycoprotein Function in Peripheral Blood Mononuclear Cells in Renal Transplant Recipients: Sex and Race Influences" Annual Meeting of Society of Clinical Pharmacology &Therapeutics, Society of Clinical Pharmacology &Therapeutics (2013)
- "P-Glycoprotein Function in Peripheral Blood Mononuclear Cells in Renal Transplant Recipients: Sex and Race Influences" Annual Meeting of Society of Clinical Pharmacology &Therapeutics, Society of Clinical Pharmacology &Therapeutics (2013)
- "Sex and haplotype Associations with Adverse Effects of Calcineurin Inhibitors Post-Transplant" Annual Meeting of Society of Clinical Pharmacology & Therapeutics, Society of Clinical Pharmacology & Therapeutics (2013)
- "27. Immunosuppressive Adverse Drug Effects: Association to Race and Sex" Roswell Medical Club Quarterly Meeting, Roswell Medical Club (2013)
- "Gender and Race influences on P-glycoprotein Function in Peripheral Blood Mononuclear Cells and Relation to Tacrolimus Adverse Effects Post-transplant" Annual Meeting of European Solid Organ Transplant, American Society of Transplantation (2012)
- "Nuclear Localization of Nuclear Factor of Activated T-Cells for Tacrolimus Immunosuppression Post-transplantation" Annual Meeting of European Solid Organ Transplant, American Society of Transplantation (2012)
- "Nuclear Localization of Nuclear Factor of Activated T-cells as a Pharmacodynamic Marker of Tacrolimus Immunosuppression in Renal Transplant Recipient" 2012 American Transplant Congress, American Society of Transplantation (2012)
- "ABCB1 Gene Expression in Peripheral Blood Mononuclear Cells in African American and Caucasian Renal Transplant Recipients;" 2012 Annual Meeting of American Society of Clinical Pharmacology & Therapeutics., ASCPT (2012)
- "Nuclear Localization of Nuclear Factor of Activated T-cells as a Pharmacodynamic Marker of Tacrolimus Immunosuppression in Renal Transplant Recipients" American Society of Transplantation Annual Scientific Exchange 2011; San antonio, TX, Ameircan Society of Transplantation (2011)
- "10. Impact of Gender and Race on Immunosuppressive Pharmacology in Stable Renal Transplant Recipients" Montreal International Biomedicine Forum 2011 with McGill University: Translational Medicine, EPS & McGill University (2011)
- "Racial Influence on ABCB1 Gene Expression in Peripheral Blood Mononuclear Cells in Stable Renal Transplant Recipients" 2011 Annual Meeting of American Society of Nephrology, American Society of Nephrology (2011)
- "Pharmacodynamic Assessment of NFAT Nuclear Localization During tacrolimus Immunosuppression in Renal Transplant Recipients." 112th American Society of Clinical Pharmacology & Therapeutics, American Society of Clinical Pharmacology & Therapeutics (2011)
- "Therapeutic Drug Monitoring of immunosuppressive Drugs" Transplant Fellow's conference, Nephrology Division; UB School of Medicine (2011)
- "Assessment of NFAT Nuclear Localization as a Pharmacodynamic Endpoint of Tacrolimus Immunosuppression in Stable Renal Transplant Recipients" American Society of Transplantation Annual Scientific Exchange 2010; Orlando, FL(Abstract #68; October 23, 2010)., American Society of Transplantation- Annual Scientific Exchange (2010)
- "Late Breakers-Nephrology Updates" 2010 Annual meeting of American College of Clincial Pharmacy, American College of Clincial Pharmacy (2010)
- "Comparison of Carefully Measured Creatinine to Clearance (CrCl) to Estimated Glomerular Filtration Rate (eGFR) in Stable Renal Transplant Recipients." 2010 Annual meeting of American Transplant Congress, American Society of Transplantation (2010)
- "Mycophenolic Acid and Metabolite Pharmacokinetics in African American (AA) and Caucasian (C) Renal Transplant Recipients receiving Enteric Coated Mycophenolic Sodium and Mycophenolate Mofetil." 2010 Annual meeting of Amertican Transplant Congress, American Society of Transplantation (2010)
- "Time Dependent Pharmacodynamic Responses of T Regulatory Cells in Stable African American and Caucasian Renal Transplant Recipients." 2010 Annual meeting of Amertican Transplant Congress, American Society of Transplantation (2010)
- "Alemtuzumab Induction Followed by Steroid Free, Low Dose Calcineurin Inhibitor Maintainence Immunosuppression in Renal Transplant Recipients-2 year Follow Up" 2009 Annual Meeting of American Society of Nephrology, American Society of Nephrology (2009)
- "Comparison of Mycophenolic Acid Pharmacokinetics in African American and Caucasian Renal Transplant Recipients Receiving Mycophenolate Mofetil and Enteric Coated Mycophenolic Sodium" 2009 Annual Meeting of American Society of Nephrology, American Society of Nephrology (2009)
- "Early Recovery of Cytomegalovirus (CMV) Specific CD8+ Lymphocytes and Decreased Incidence of CMV Infection in Renal Transplant Recipients Induced with Alemtuzuab (CAM1H)" 2009 Annual Meeting of American Society of Nephrology, Amierican Society of Nephrology (2009)
- "Aggressive Immunosuppression Benefits Post-transplant Glomerulonephritis" Annual Meeting of American Society of Transplantation (2009)
- "Gender Differences in Cyclosporine Pharmacokinetics in Stable African American and Caucasian Renal Allograft Recipients" Annual Meeting of American Society of Transplantation, AST (2009)
- "Assessment of P-glycoprotein in Peripheral Mononuclear Cells in African American and Caucasian Renal Transplant Recipients During Chronic cyclosporine Therapy" Annual Meeting of American Society of Clinical Pharmacology and Therapeutics, ASCPT (2009)
- "Time Dependent Expression of MRP-2 in Periperhal Mononuclear Cells in African American and Caucasian Renal Transplant Recipients" Annual Meeting of American Society of Clinical Pharmacology and Therapeutics, ASCPT (2009)
- "Effect of Steroid Avoidance and Low Dose Calcinuerin-Inhibitor Immunosuppression on Progression of Chronic Allograft Nephropathy (CAN) Assessed by Surveillance Biopsy" American Society of Nephrology, ASN (2008)
- "25. Integration of Clinical Pharmacy Education with Scholarly Activity: One Perspective;" Visiting Professor, Albany College of Pharmacy (2008)
- "Effect of Steroid Free Mainatenance Immunosuppression Protocol on Progression of Chronic Allograft Nephropathy" American Transplant Congress (2008)
- "Influence of Cyclosporine Exposure on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients" American Transplant Congress (2008)
- "Quantitative real-time PCR Analysis of MRP-2 Expression in Peripheral Mononuclear Cells" Clin Pharmacol Ther (2008)
- "Cyclosporine Gender Differences with 12 hour Pharmacokinetic Analysis in Stable Renal Allograft Recipients" 39th Annual Meeting of the American Society of Nephrology (2007)
- "Outcomes of Alemtuzumab Induction in High Risk Renal Transplant Recipients" 39th Annual Meeting of the American Society of Nephrology (2007)
- ". Comparison of Cyclosporine Concentrations in Renal Transplant Recipients(RTR) during Pharmacokinetic Evaluation using Two Assays: TurboflowT versus Fluorescence Polarimetry Immunoassay." AACC (2007)
- "Influence of race, steroid use and Renal function on Mycophenolic Acid Pharmacokinetics in Renal Transplant Recipients" American Transplant Congress. (2007)
- "Influence of Steroid Use and Gender on Mycophenolic Acid Pharmacokinetics Post-Renal Transplant" American Transplant Congress (2007)
- "Maintenance Steroid Free Campath-1H Induction Regimen Reduces Metabolic Complications" American Transplant Congress (2007)
- "One year Results of Alemtuzumab Induction, Calcineurin Minimization Protocol in Renal Transplant Recipients Monitored by Surveillance Biopsies" American Transplant Congress (2007)
- "Impact of Gender, Race and Time on MDR-1 Gene Expression in Stable Renal Transplant Recipients" 108th Annual Meeting of American Society for Clinical Pharmacology and Therapeutics, (2007)
- "Influence of Race and Steroid Use on Mycophenolic Acid Pharamcokinetics Post- Renal Transplant" 108th Annual Meeting of American Society for Clinical Pharmacology and Therapeutics, (2007)
- "Population Pharmacokinetic Model of Mycophenolic Acid and its Metabolite-Mycophenolic Acid Glucuronide in Long Term Renal Transplant Patients using Monte CArlo Parametric Expectation Maximization" 108th Annual Meeting of American Society for Clinical Pharmacology and Therapeutics, (2007)
Service Activities:
- Abstract Reviewer; American Society of Clinical Pharmacology & Therapeutics Dr. Tornatore functioned as an abstract reviewer for annual meeting of ASCPT in the category of organ specific diseases.; Reviewer (2013)
- ASCPT Organ Specific disease; ASCPT Development of pharmacology based education program for ASCPT Annual meeting on Hepatitis C and Liver transplantation; Other (2013)
- Internal Reviewer for SoPPS Clinical Pharmacy Faculty dossier for promotion; UB SoPPS Pharmacy Practice Dr. Tornatore functioned as an Internal Reviewer of a dossier for clinical pharmacy faculty member within the UB SoPPS Department of Pharmacy Practice; Reviewer (2013)
- Visiting Professor; Univeristy of Nebraska School of Pharmacy/Medical Center Provided a State of the Art lecture entitled: The influence of Race and Sex on Immunosuppressive Pharmacology: Implications of P-glycoprotein to Pharmacy Department; meeting with Pharmacy Resident; Other (2012)
- External Reviewer for Acadmic Promotion for clinical pharmacy faculty; Harvard Medical School- Womens Brigham Young Dr. Tornatore functioned as an External Reviewer of a dossier for clinical pharmacy faculty member within the Department of Medicine/Transplantation; Other (2012)
- Community of Practice(COP)-Basic & Translational Sciences; American Society of Transplantation Dr. Tornatore was appointed as the Liaison from the COP for Pharmacy to the Community of Practice for Basic & Translational Research within the AST. My goal is to facilitate information and research endeavors where T; Other (2012)
- Translational Pharmacology Research core (TRPC); Member (2011)
- Community of Practice-Transplant Pharmacists; American Society of Transplantation I have been appointed as the Liaison from the COP to the Community of Practice for Women's Health COP within the AST. My goal is to facilitate information and research endeavors where Transplant Pharmacists can collabo; Other (2011)
- Renal Lecture Series; Particpation in the nephrologist and fellow Continuing Education sequence within the Department of Medicine. This presetnation was: Update of Therapetuic Drug Monitoring of Immunosuppressive Drugs; Other (2011)
- Immunosuppressive Pharmacology Research Program; This is multi-disciplinary group composed of members from Pharmacy Practice, Biostatistics & Medicine from UB & COE, RPCI Flow Cytometry & Pharmacogenomics Laboratory at NEM College of Pharmacy/Medicine to address ongoing clinical pharmacology studies.; Other (2010)
- Mission, Planning & Evaluation Sub-Committee Accreditation 2011; The goal of this committe was to revise the Mission of SOPPS and to create a Strategic Plan for the next five years relative the steps to accomplish the Mission of SOPPS.; Member (2010)
- Community of Practice Transplant Pharmacists; American Society of Transplantation; Other (2009)
- Community of Practice-Transplant Pharmacists; American Society of Transplantation; Other (2009)
- SoPPS Faculty Teaching Award; Member (2009)
- Women's Health Community of Practice; American Society of Transplantation; Member (2008)
- Women's Health Community of Practice; American Society of Transplantation; Member (2007)
- Annual Meeting Program Committee; American College of Clinical Pharmacy This committee helped to organize and plan the integrated program for the 2007 Annual ACCP meeting. I was the co-chair within this committee responsible for the development of the 3 day educational sequence ""Compl; Other (2005)
- Faculty Liaison; American College of Clinical Pharmacy Faculty Liasion for ACCP where we interact with the Pharm.D. students and encourage their participation in the ACCP as wel as explain the post-graduate activities such as residencies and fellowships.; Other (2005)
- Pharmacy Department Promotion & Tenure Comm; Member (2004)
- Fellowship Committee; Member (2003)
- Immunosuppressive Fellowship Director; Coordinator (2001)
- ASHP Nephrology/Transplantation Residency; Coordinator (2001)
- SoPPS Tenure & Promotion Committee; Member (2000)
- Pharmacotherapeutics Course Coordinators Committee; The goals and accomplishments of the Course Coordinators is to maintain continuity of therapeutics materical as well as provision of faculty mentoring and consistency.; Coordinator
- SOPPS Awards Committee; The committee addresses the Awards on an annual basis and the corresponding faculty in the SOPPS that may be nomiated for thse awards.; Member