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Pharmacokinetic-Pharmacodynamic Modeling

May 8-10, 2017
Niagara Falls, NY

Our classic 3-day course on the concepts and applications of PK/PD modeling will be presented on a level suitable for those knowledgable in basic pharmacokinetics.

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Course Outline

We present the theory and applications of  pharmacodynamics. With diverse  pharmacokinetic-pharmacodynamic modeling concepts it is possible to describe and predict the time course of drug effects under various physiological and pathological conditions. The study of PK/PD and Disease Progression relationships can be of considerable value in understanding drug action, summarizing extensive data, building a knowledge repository, finding optimal dosing regimens, and in making predictions under new circumstances.  More advanced PK/PD models have evolved into Systems Pharmacology.

Special Note: We are offering this course and hotel venues adjacent to Niagara Falls with a large array of vacation activities including casinos. Bring your family!

Course Direction

William J. Jusko, PhD
Dr. Jusko is SUNY Distinguished Professor of Pharmaceutical Sciences at the University of Buffalo and Director of the Center of Excellence in Pharmacokinetics and Pharmacodynamics. He is Editor-in-Chief of JPKPD, has authored over 600 publications, consults for the FDA, NIH, and the pharmaceutical industry, and is listed in ISI Most Highly Cited in Pharmacology.


Donald E. Mager, PhD
Dr. Mager is Professor of Pharmaceutical Sciences at the University at Buffalo. He has served as Visiting Professor at the Université Paris Descartes and on the Advisory Committee on Clinical Pharmacology to the FDA. His research invokes PK/PD systems analysis with particular interest in anti-cancer and immunomodulatory pharmacotherapy.

Course Program

Monday, May 8   Tuesday, May 9
  Wednesday, May 10  
08:00-08:30 Continental Breakfast/Registration 08:00-08:30 Continental Breakfast 08:00-08:30 Continental Breakfast
08:30-08:45 Dr. W.J. Jusko: Introductions 08:30-09:45 Dr. D. Mager: Review & Exercises I 08:30-09:45 Dr. W.J. Jusko: Review & Exercises II
08:45-09:45 Dr. W.J. Jusko: Overview of PK/PD 09:45-10:00 Coffee 09:45-10:00 Coffee
09:45-10:45 Dr. D. Mager: Art of Modeling 10:00-11:00 Dr. W.J. Jusko: Modeling Chemotherapeutic Effects 10:00-11:00 Dr. D. Shah: PKPD Monoclonal Antibodies
10:45-11:00 Coffee 11:00-12:00 Dr. W.J. Jusko: Complexities of Indirect Responses 11:00-12:00 Dr. W.J. Jusko: Disease Progression Models
11:00-12:00 Dr. D. Mager: Basic Pharmacology 12:00-01:00 Lunch 12:00-01:00 Lunch
12:00-01:00 Lunch 01:00-02:00 Dr. W.J. Jusko: Modeling Functional Adaptation 01:00-02:00 Dr. D. Mager:  Species Scaling in PKPD
01:00-02:00 Dr. W.J. Jusko: Modeling Biophase Distribution 02:00-03:00 Dr. D. Mager: Target-Mediated PK/PD Models 02:00-03:00 Dr. J. Earp: FDA & Pharmacometrics
02:00-03:00 Dr. W.J. Jusko: Basic Indirect Response Models 03:00-03:15 Refreshments 03:00-03:15 Refreshments
03:00-03:15 Break 03:15-04:15 Dr. W.J. Jusko : Modeling Drug Interactions 03:15-04:15 Dr. D. Mager: Systems Modeling in PK/PD
03:15-04:15 Dr. D. Mager: Modeling Transduction Processes 04:15-05:15 Pf. J. Fiedler-Kelly: Population PK/PD Models 04:15-04:30 Dr. W.J. Jusko: Final Discussion and Summary
04:15-05:00 Dr. W.J. Jusko: Slow & Irreversible Effects        
06:00-07:30 Group Dinner        

Registration Information


Individual fee: $2,500. This includes course documentation, continental breakfasts, mid-session refreshments, lunches and opening dinner. Up to five (5) graduate students may enroll at a fee of $1200 (registered MS and PhD).  US Government rate: $1,900 (FDA and NIH employees only).


Cancellations with a full refund may be made until March 13, 2017. No refund  is  possible on cancellations received after this date. Substitutions may be made at any time. 

Course Location

The course will be held at:
The Conference and Event Center Niagara Falls
101 Old Falls Street
Niagara Falls, NY 14303, USA
Phone: (716) 278-2100
Fax: (716) 278-0008

The Conference Center is 28 minutes from the Buffalo Niagara International Airport.

Hotel Location

Sheraton at the Falls
300 Third Street
Niagara Falls, NY 14303, USA
Phone: (716) 285-3361.

The price is $124/night single and double occupancy (add $10 per person for triple and quadruple occupancy).

Hotel deadline: April 3, 2017


Contact UB course secretary Suzette Mis at (716) 645-4831 or if you need assistance.

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