Pharmacokinetic-Pharmacodynamic Modeling


Monday, May 18 - Wednesday, May 20, 2020
Niagara Falls, NY

Our classic 3-day course on the concepts and applications of PK/PD modeling will be presented on a level suitable for those knowledgable in basic pharmacokinetics.

On this page:

Course Outline

We present the theory and applications of  pharmacodynamics. With diverse pharmacokinetic-pharmacodynamic modeling concepts it is possible to describe and predict the time course of drug effects under various physiological and pathological conditions. The study of PK/PD and Disease Progression relationships can be of considerable value in understanding drug action, summarizing extensive data, building a knowledge repository, finding optimal dosing regimens, and in making predictions under new circumstances.  More advanced PK/PD models have evolved into Systems Pharmacology.

Special Note: We are offering this course and hotel venues adjacent to Niagara Falls with a large array of vacation activities including casinos. Bring your family!

Course Direction


William J. Jusko, PhD
Dr. Jusko is SUNY Distinguished Professor of Pharmaceutical Sciences at the University of Buffalo and Director of the Center of Excellence in Pharmacokinetics and Pharmacodynamics. He is Editor-in-Chief of JPKPD, has authored over 600 publications, consults for the FDA, NIH, and the pharmaceutical industry, and is listed in ISI Most Highly Cited in Pharmacology.



Donald E. Mager, PhD
Dr. Mager is Professor of Pharmaceutical Sciences at the University at Buffalo. He has served as Visiting Professor at the Université Paris Descartes and on the Advisory Committee on Clinical Pharmacology to the FDA. His research invokes PK/PD systems analysis with particular interest in anti-cancer and immunomodulatory pharmacotherapy.

Course Program

Monday, May 18, 2020

08:00-08:30 Continental Breakfast/Registration
08:30-08:45 Dr. W.J. Jusko: Introductions
08:45-09:45 Dr. W.J. Jusko: Overview of PK/PD
09:45-10:45 Dr. D. Mager: Art of Modeling
10:45-11:00 Coffee
11:00-12:00 Dr. D. Mager: Basic Pharmacology
12:00-01:00 Lunch
01:00-02:00 Dr. W.J. Jusko: Modeling Biophase Distribution
02:00-03:00 Dr. W.J. Jusko: Basic Indirect Response Models
03:00-03:15 Break
03:15-04:15 Dr. D. Mager: Modeling Transduction Processes
04:15-05:00 Dr. W.J. Jusko: Slow & Irreversible Effects 
05:00-06:00 Cocktail Hour
06:00-07:30  Group Dinner

Tuesday, May 19, 2020

08:00-08:30 Continental Breakfast
08:30-09:45 Dr. D. Mager: Review & Exercises I
09:45-10:00 Coffee
10:00-11:00 Dr. W.J. Jusko: Chemotherapy Models
11:00-12:00 Dr. W.J. Jusko: Indirect Response Complexities
12:00-01:00 Lunch
01:00-02:00 Dr. W.J. Jusko: Modeling Tolerance Processes
02:00-03:00 Dr. D. Mager: Target-Mediated PK/PD Models
03:00-03:15 Refreshments
03:15-04:15 Dr. W.J. Jusko : Modeling Drug Interactions
04:15-05:15 Pf. J. Fiedler-Kelly: Population PK/PD Models

Wednesday, May 20, 2020

08:00-08:30 Continental Breakfast
08:30-09:45 Dr. W.J. Jusko: Review & Exercises II
09:45-10:00 Coffee
10:00-11:00 Dr. D. Shah: PKPD Monoclonal Antibodies
11:00-12:00 Dr. W.J. Jusko: Disease Progression Models
12:00-01:00 Lunch
01:00-02:00 Dr. D. Mager: Species Scaling in PKPD
02:00-03:00 Dr. J. Earp: FDA & Pharmacometrics
03:00-03:15 Refreshments
03:15-04:15 Dr. D. Mager: Systems Modeling in PK/PD
04:15-04:30 Dr. W.J. Jusko: Final Discussion and Summary

Registration Information


Individual fee: $2,800. This includes course documentation, continental breakfasts, mid-session refreshments, lunches and opening dinner. Up to 5 graduate students may enroll at a fee of $1,400 (registered MS and PhD).


Cancellations with a full refund may be made until March 16, 2020. No refunds will be given for cancellations received after this date. Substitutions may be made at any time.

Course Location

The course will be held at:
The Conference and Event Center Niagara Falls
101 Old Falls Street
Niagara Falls, NY 14303, USA
Phone: (716) 278-2100
Fax: (716) 278-0008

The Conference Center is 28 minutes from the Buffalo Niagara International Airport.

Hotel Location

Book your group rate for University at Buffalo Pharmacokinetic Modeling

Sheraton at the Falls
300 Third Street
Niagara Falls, NY 14303, USA
Phone: (716) 285-3361.

The price is $94/night single and double occupancy (add $10 per person for triple and quadruple occupancy).

Hotel deadline: April 13, 2020

Questions or looking for a printable course flyer?

Contact UB course secretary Suzette Mis at (716) 645-4831 or if you need assistance.