Center for Protein Therapeutics Symposium

Faculty, post-doctoral fellows and graduate students from the School of Pharmacy and Pharmaceutical Sciences present the results of ten research projects that were funded by the CPT during the past year. 

2019 Agenda

8:30 a.m. Registration / Coffee
8:55 a.m. Introduction to the Eleventh Annual Symposium (Dr. J. Balthasar)
9:00 a.m. Sensitive, accurate investigation of biotherapeutics and biomarker/target levels in both fresh and FFPE tissues, and application in Inflammatory bowel diseases (Qu Lab)
9:30 a.m. Extensive investigation of ocular tissue disposition of antibody-drug conjugates (Qu Lab)
10:00 a.m. Study viable approaches for oral delivery of colon-targeting macromolecules (e.g. targeting TNF for IBD), and understand the gut absorption mechanism following oral delivery (Balu-Iyer Lab)
10:30 a.m. Break
11:00 a.m. Tumor selectivity of anti-carcinoembryonic antigen scFv, scFv-ABD, and monoclonal antibodies in a mouse model of human colorectal cancer (J. Ryan Polli, Balthasar Lab) 
11:30 a.m. PK/PD Modeling of Liposomal IL-12 Enhancement of Human Tumor-Specific T Cell Killing (Mager Lab)
12:00 p.m. Lunch
1:30 p.m. Brain Pharmacokinetics of Different Size Antibody Fragments (Shah Lab)
2:00 p.m. Clinical Validation of Antibody PBPK Model Using 89Zr Labelled Imaging Studies (Shah Lab)
2:30 p.m. BCSFB transport of protein therapeutics: Influence of Type 2 Diabetes (Morris Lab)
3:00 p.m. Break
3:20 p.m. Dynamic contrast enhanced magnetic resonance imaging for the prediction of monoclonal antibody tumor disposition (Brandon Bordeau, Balthasar Lab)
3:50 p.m. Multiparametric MRI-based physiological imaging to predict mAb penetration and efficacy in pancreatic cancer  (Straubinger Lab)
4:20 p.m. Visualizing the Renal Disposition of Proteins and Peptides using Two-Photon Microscopy (Morris Lab)
4:50 p.m. Concluding Remarks (J. Balthasar)