Center for Protein Therapeutics Symposium

Date: July 30, 2018

Location:190 Kapoor Hall, University at Buffalo South Campus

Fee: There is no fee for the symposium for members of CPT consortium, sponsors, or for students, fellows, or faculty of the University at Buffalo. Lunch and break-time refreshments will be provided.

Homewood Suites Amherst

Buffalo Marriott Niagara

Hyatt Place Buffalo/Amherst


8:30 a.m. Registration / Coffee
8:55 a.m. Introduction to the Tenth Annual Symposium
Dr. J. Balthasar
9:00 a.m. Experimental validation of factors identified by modeling and simulation that control mAb penetration and efficacy in pancreatic cancer
Straubinger Lab
9:30 a.m. Dynamic contrast enhanced magnetic resonance imaging for the prediction of monoclonal antibody tumor disposition
Balthasar Lab
10:00 a.m. Pharmacodynamics of checkpoint antibodies in combination with patient-derived melanoma specific CD8+ T-cells that are persistently activated in the microenvironment of melanoma tumor xenograft
Mager Lab
10:30 a.m. Break
11:00 a.m. Investigation of differences in the disposition of 8C2 mAb and scFv in select brain regions of control mice and in a mouse model of Alzheimer’s disease
Balthasar Lab
11:30 a.m. High throughput, spatially-resolved tissue micro-sampling coupled to sensitive nano-LCMS to determine the heterogeneous distribution of mAb and targets in bone marrow, lymph nodes and regions of brain
Qu Lab
12:00 p.m. Lunch
1:30 p.m. Physiologically-Based Modeling for T-cell Engaging Bispecific Antibodies
Balthasar Lab
2:00 p.m. Development of the Quantitative Relationship between Protein Size and Tumor Exposure
Shah Lab
2:30 p.m. Endogenous T-Cell Redistribution in the Presence of Immuno-Oncology (I-O) Treatments
Shah Lab
3:00 p.m. Break
3:20 p.m. Role of Megalin in the Renal Clearance of Peptide Therapeutics
Morris Lab
3:50 p.m. Pharmacokinetics of Anti-TfR Antibody Affinity Variants in Rat Brain Using Microdialysis
Shah Lab
4:20 p.m. Concluding Remarks
Dr. J. Balthasar