Center for Protein Therapeutics Symposium

Faculty, post-doctoral fellows, and graduate students from the School of Pharmacy and Pharmaceutical Sciences present the results of ten research projects that were funded by the CPT during the past year. 

2018 Agenda

8:30 a.m. Registration / Coffee
8:55 a.m. Introduction to the Tenth Annual Symposium
Dr. J. Balthasar
9:00 a.m. Experimental validation of factors identified by modeling and simulation that control mAb penetration and efficacy in pancreatic cancer
Straubinger Lab
9:30 a.m. Dynamic contrast enhanced magnetic resonance imaging for the prediction of monoclonal antibody tumor disposition
Balthasar Lab
10:00 a.m. Pharmacodynamics of checkpoint antibodies in combination with patient-derived melanoma specific CD8+ T-cells that are persistently activated in the microenvironment of melanoma tumor xenograft
Mager Lab
10:30 a.m. Break
11:00 a.m. Investigation of differences in the disposition of 8C2 mAb and scFv in select brain regions of control mice and in a mouse model of Alzheimer’s disease
Balthasar Lab
11:30 a.m. High throughput, spatially-resolved tissue micro-sampling coupled to sensitive nano-LCMS to determine the heterogeneous distribution of mAb and targets in bone marrow, lymph nodes and regions of brain
Qu Lab
12:00 p.m. Lunch
1:30 p.m. Physiologically-Based Modeling for T-cell Engaging Bispecific Antibodies
Balthasar Lab
2:00 p.m. Development of the Quantitative Relationship between Protein Size and Tumor Exposure
Shah Lab
2:30 p.m. Endogenous T-Cell Redistribution in the Presence of Immuno-Oncology (I-O) Treatments
Shah Lab
3:00 p.m. Break
3:20 p.m. Role of Megalin in the Renal Clearance of Peptide Therapeutics
Morris Lab
3:50 p.m. Pharmacokinetics of Anti-TfR Antibody Affinity Variants in Rat Brain Using Microdialysis
Shah Lab
4:20 p.m. Concluding Remarks
Dr. J. Balthasar