About Dr. Qu

Jun Qu.

Jun Qu Faculty Profile

Jun Qu is a Professor in Department of Pharmaceutical Sciences at the University at Buffalo, and the Chief Scientist in Bioanalysis at the New York State Center of Excellence in Bioinformatics and Life Sciences.

Dr. Jun Qu's primary appointment is in the Department of Pharmaceutical Sciences at SUNY Buffalo. He recieved his PhD in Analytical Chemistry at Tsinghua University, Beijing, China, in 2002.

His interests are in Proteomics and Pharmaceutical Analysis, and his research programs in the proteomics field involve:

  1. High-resolution and large-scale expression profiling of pathological proteomes (e.g. for cardiovascular diseases, colon cancer and infectious diseases, HIV, COPD, etc) for the discovery of disease/therapeutic biomarkers by gel-free LC/MS methods;
  2. Sensitive identification, localization and quantification of post-translational modifications in complex proteomes, with the emphases on arginine methylation and phosphorylation. Novel anti-PTM-peptides capture procedure and alternating collision induced dissociation (CID)/electron transferring dissociation (ETD) are employed to obtain abundant PTM information;
  3. Targeted quantification of regulatory, marker proteins for clinical study. 

Dr. Qu's lab possesses many state-of-the-art LC/MS instruments, including a high resolution/accuracy Orbitrap Fusion Lumos, two highly sensitive TSQ triple quadrupole instruments (one Altis, one Quantiva), three ultra-high pressure nano-LC systems, and several HPLC instruments for pre-fraction and ion chromatography. A number of key analytical advances have been developed by his lab that greatly enhanced the proteomic coverage, sensitivity and throughput for proteomic research.

As for the Pharmaceutical Analysis of small-molecule drug/markers, Dr. Qu's lab is focusing on the ultra-sensitive quantifications of drug, metabolites and endogenous markers (e.g. corticosteroids, di-hydroxyl-vitamin D metabolites, androgens, etc.) using a novel combination of selective enrichment and micro- or nano-LC/MS.