EDUCATING LEADERS IN PHARMACY AND PHARMACEUTICAL SCIENCES SINCE 1886
Youngjae You PhD
Youngjae You
PhD
Professor of Empire Innovation
Department of Pharmaceutical Sciences
Specialty/Research Focus
Antibody-Drug Conjugates; Cancer Chemotherapy; Drug Delivery; Medicinal Chemistry; Targeted Drug Delivery
Education and Training:
- PhD, Pharmaceutical Chemistry, Chungnam National University (2001)
- MS, Pharmaceutical Chemistry, Chungnam National University (2000)
- BPharm, Chungnam National University (1994)
Employment:
- Professor, Pharmaceutical Sciences, University at Buffalo (2019-present)
- Adjunct Professor, Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, College of Medicine (2019)
- Professor, Pharmaceutical Sciences, University of Oklahoma Health Sciences Center (2018–2019)
- Adjunct Professor, Peggy and Charles Stephenson School of Biomedical Engineering, Universtiy of Oklahoma, Gallogly College of Engineering (2018–2019)
- Investigator, Peggy and Charles Stephenson Oklahoma Cancer Center (2011–2019)
- Associate Professor, Pharmaceutical Sciences, Univesity of Oklahoma Health Sciences Center (2010–2018)
- Adjunct Associate Professor, Chemistry and Biochemistry, University of Oklahoma (2010–2018)
- Assistant Professor, Chemistry and Biochemistry, South Dakota State University (2006–2010)
- Research Assistant Professor, Chemistry, University at Buffalo (2004–2006)
- Post Doctoral Fellow, Chemistry, University at Buffalo (2001–2004)
- Pharmacist, Dok-il Community Pharmacy, Korea, Republic Of (1995)
Awards and Honors:
- Professor of Empire Innovation, University at Buffalo (2019)
- PHF Presidential Professorship, OUHSC (2018)
- Idea Award with Special Focus, Peer Reviewed Cancer Research Program (CDMRP, DOD) (2016)
- Idea Expansion Award, Breast Cancer Research Program (CDMRP, DOD) (2014)
- Research Scholar Grants Award, American Cancer Society (2013)
- Breast Cancer Seed Grant: Stephenson Cancer Center (2011)
- Idea Award, Breast Cancer Research Program (CDMRP, DOD) (2008)
- Research/Scholarship Support Award, SDSU (2007)
- Research/Scholarship Support Award for New faculty, SDSU (2006)
- Postdoctoral Fellowship Award, Breast Cancer Research Program (CDMRP, DOD) (2003)
- Health Science Fellowship - Korean Health Science Foundation (1996)
Research Expertise:
- Pharmaceutical Chemistry & Drug Delivery: Pharmaceutical Chemistry, Drug Delivery, Photodynamic Therapy, Photochemistry, PK/PD Modeling
Grants and Sponsored Research:
- July 2022–June 2027
Singlet Oxygen-cleavable Prodrugs for Treating Non-Muscle Invasive Bladder Cancers
National Cancer Institute/ NIH
Role: Principal Investigator
$2,104,600 - September 2018–August 2021
Mechanistic Studies of gamma-Glutamyl Transpeptidase inhibition: a Novel Approach to Modulating Serum Levels of Cysteine
NIGMS
Role: Co-Investigator
$975,672 - August 2017–July 2020
Visible Light-Controlled Combination Strategy for Treating Nonmuscle Invasive Bladder Cancers
DoD/CDMRP/PRCRP
Role: Principal Investigator
$392,000 - March 2015–January 2020
NIR-activatable Prodrugs for Treating Peritoneally Metastasized Ovarian Cancers
NIH/NIGMS
Role: Principal Investigator
$1,517,000 - September 2014–September 2017
A Synergistic Combination Therapy of Photodynamic Therapy and Chemotherapy for Breast Cancer
DoD/CDMRP/BCRP
Role: Principal Investigator
$554,826 - July 2016–June 2017
Administrative Supplement for purchasing 300 MHz NMR system
NIH/NIGMS
Role: Principal Investigator
$128,900 - July 2013–June 2016
Fluorescence Cystoscopy-Photodynamic Therapy for Early Bladder Cancers
American Cancer Society
Role: Principal Investigator
$527,460 - September 2012–August 2013
Identifying the DRUG target in dormant cancer cells
NIH/NCI
Role: Co-Investigator
$81,281 - February 2009–September 2012
Targeted Delivery and Remote-Controlled Release of Chemotherapeutic Agents
DoD/CDMRP/BCRP
Role: Principal Investigator
$503,664
Patents:
- BODIPY derivatives and methods of synthesis and use thereof (2017)
- Singlet oxygen-labile linkers and methods of production and use thereof (2016)
Journal Articles:
- Subramaniyan B, Rajaputra P, Nguyen L, Li M, Peer CJ, Kindrick J, Figg WD, Woo S, You Y. Local and systemic antitumor effects of photo-activatable paclitaxel prodrug on rat breast tumor models Photochemistry and Photobiology. 2019.
- Li M, Nguyen L, Subramaniyan B, Bio M, Peer CJ, Kindrick J, Figg WD, Woo S, You Y. PBPK modeling-based optimization of site-specific chemo-photodynamic therapy with far-red light-activatable paclitaxel prodrug. J Control Release. 2019; 308.
- Bio M, Rahman KMM, Lim I, Rajaputra P, Hurst RE, You Y. Singlet oxygen-activatable Paclitaxel prodrugs via intermolecular activation for combined PDT and chemotherapy. Bioorg Med Chem Lett. 2019; 29(12).
- Li M, Thapa P, Rajaputra P, Bio M, Peer CJ, Figg WD, You Y, Woo S. Quantitative modeling of the dynamics and intracellular trafficking of far-red light-activatable prodrugs: implications in stimuli-responsive drug delivery system. J Pharmacokinet Pharmacodyn. 2017; 44(6).
- Thapa P, Li M, Karki R, Bio M, Rajaputra P, Nkepang G, Woo S, You Y. Folate-PEG Conjugates of a Far-Red Light-Activatable Paclitaxel Prodrug to Improve Selectivity toward Folate Receptor-Positive Cancer Cells. ACS Omega. 2017; 2(10).
- Bio M, Rajaputra P, Lim I, Thapa P, Tienabeso B, Hurst RE, You Y. Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria. Chem Commun (Camb). 2017; 53(11).
- Thapa P, Li M, Bio M, Rajaputra P, Nkepang G, Sun Y, Woo S, You Y. Far-Red Light-Activatable Prodrug of Paclitaxel for the Combined Effects of Photodynamic Therapy and Site-Specific Paclitaxel Chemotherapy. J Med Chem. 2016; 59(7).
- Rajaputra P, Bio M, Nkepang G, Thapa P, Woo S, You Y. Anticancer drug released from near IR-activated prodrug overcomes spatiotemporal limits of singlet oxygen. Bioorg Med Chem. 2016; 24(7).
- Bio M, Rajaputra P, You Y. Photodynamic therapy via FRET following bioorthogonal click reaction in cancer cells. Bioorg Med Chem Lett. 2016; 26(1).
- Watley RL, Awuah SG, Bio M, Cantu R, Gobeze HB, Nesterov VN, Das SK, D‘Souza F, You Y. Dual Functioning Thieno-Pyrrole Fused BODIPY Dyes for NIR Optical Imaging and Photodynamic Therapy: Singlet Oxygen Generation without Heavy Halogen Atom Assistance. Chem Asian J. 2015; 10(6).
- Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA. Identification of novel drugs to target dormant micrometastases. BMC Cancer. 2015; 15.
- Nkepang G, Bio M, Rajaputra P, Awuah SG, You Y. Folate receptor-mediated enhanced and specific delivery of far-red light-activatable prodrugs of combretastatin A-4 to FR-positive tumor. Bioconjug Chem. 2014; 25(12).
- Bandi V, Das SK, Awuah SG, You Y, D‘Souza F. Thieno-pyrrole-fused 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-fullerene dyads: utilization of near-infrared sensitizers for ultrafast charge separation in donor-acceptor systems. J Am Chem Soc. 2014; 136(21).
- Bio M, Rajaputra P, Nkepang G, You Y. Far-red light activatable, multifunctional prodrug for fluorescence optical imaging and combinational treatment. J Med Chem. 2014; 57(8).
- Awuah SG, Das SK, D‘Souza F, You Y. Thieno-pyrrole-fused BODIPY intermediate as a platform to multifunctional NIR agents. Chem Asian J. 2013; 8(12).
- Ngen EJ, Xiao L, Rajaputra P, Yan X, You Y. Enhanced singlet oxygen generation from a porphyrin-rhodamine B dyad by two-photon excitation through resonance energy transfer. Photochem Photobiol. 2013; 89(4).
- Bio M, Rajaputra P, Nkepang G, Awuah SG, Hossion AM, You Y. Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry. J Med Chem. 2013; 56(10).
- Rajaputra P, Nkepang G, Watley R, You Y. Synthesis and in vitro biological evaluation of lipophilic cation conjugated photosensitizers for targeting mitochondria. Bioorg Med Chem. 2013; 21(2).
- Hossion AM, Bio M, Nkepang G, Awuah SG, You Y. Visible Light Controlled Release of Anticancer Drug through Double Activation of Prodrug. ACS Med Chem Lett. 2013; 4(1).
- Bio M, Nkepang G, You Y. Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release. Chem Commun (Camb). 2012; 48(52).
- Nkepang G, Pogula PK, Bio M, You Y. Synthesis and singlet oxygen reactivity of 1,2-diaryloxyethenes and selected sulfur and nitrogen analogs. Photochem Photobiol. 2012; 88(3).
- Awuah SG, Polreis J, Biradar V, You Y. Singlet oxygen generation by novel NIR BODIPY dyes. Org Lett. 2011; 13(15).
Books and Book Chapters:
- You Y. Heteroatom-substituted dioxetanes and their emerging biomedicalapplications. 2014.
Professional Memberships:
- International Society for Optics and Photonics (SPIE) (2019–present)
- American Society for Pharmacology and Experimental Therapeutics (2016–present)
- American Associate of College of Pharmacy (2010–present)
- American Society for Photobiology (2006–present)
- American Association of Pharmaceutical Scientists (2005–present)
- American Association of Cancer Research (2005–present)
- American Chemical Society (2002–present)
- Pharmaceutical Society of Korea (1995–present)