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Kathleen                       Boje

Kathleen M. Boje PhD

Department of Pharmaceutical Sciences

Associate Dean for Academic Affairs, Associate Professor

 
Professional Summary:

Research interests include:

1. Innovations in pedagogy and educational technologies.

2. Drug transport across the blood-brain barrier. Focuses on the mechanisms of drug transport across the blood-brain and blood-cerebrospinal fluid barriers. Nature designed these barriers to restrict and regulate the entry of blood borne substances into brain tissue. Essential nutrients are transported efficiently by carrier proteins expressed by the blood-brain and blood-cerebrospinal fluid barriers. However, these barriers hinder the entry of many drugs, and typically it is only highly lipophilic drugs that gain access to brain tissue via passive diffusion across the barriers. Consequently, many lead drug candidates are disqualified from further development because of poor permeability across the blood-brain barrier. There is much scientific interest in understanding brain transport processes with the goal of identifying methods, which enhance drug delivery across brain barriers.

3. Neuroinflammatory Brain Diseases. Understanding the role of neuroinflammatory processes in the progression of chronic neurodegenerative diseases. Since inflammatory processes are a common feature of many neurological diseases (viz., Alzheimer‘s disease, multiple sclerosis, HIV-1 dementia,cerebral ischemia, brain tumors and meningitis), an enhanced knowledge of inflammatory mediators and their detrimental effects on the centraln ervous system provides opportunities for the design of new pharmaceutical approaches in the management of neurological diseases.

Education and Training:
  • Certification in Educational Technology, University of Buffalo, State University of New York (2002)
  • PhD, State University of New York at Buffalo (1988)
  • BS, Duquesne University, Summa cum laude (1983)
Employment:
  • Associate Dean, Academic Affairs, Pharmaceutical Sciences, University at Buffalo (2014-present)
  • Associate Professor (1998-present)
  • Director and Advisor, Pharmaceutical Sciences BS Major (1996-present)
  • Vice Chair (2002–2014)
  • Associate Professor (1998)
  • Assistant Professor (1992–1998)
  • Director and Advisor, Pharmaceutical Sciences BS Major (1996)
  • Assistant Professor (1992)
  • Staff Fellow (1991–1992)
  • Guest Laboratory Lecturer in Receptor Binding Techniques (1990–1992)
  • Staff Fellow (1991)
  • PRAT Staff Fellow (1989–1991)
  • Guest Laboratory Lecturer in Receptor Binding Techniques (1990)
  • PRAT Staff Fellow (1989)
  • Post-Doctoral Fellow (1988–1989)
  • Post-Doctoral Fellow (1988)
See all (6 more)
Awards and Honors:
  • American Association of Colleges of Pharmacy Academic Leadership Fellow (2016)
  • (2004)
  • Chancellor's Award for Excellence in Teaching (2004)
  • Innovations in Teaching (2004)
  • Rho Chi Excellence in Teaching Award (1997)
  • American Association of Pharmaceutical Scientists: (1992)

Research Expertise:
  • Drug transport across the blood-brain barrier: Mechanisms of drug transport across the blood-brain and blood-cerebrospinal fluid barriers. These barriers hinder the entry of many drugs, and typically it is only highly lipophilic drugs that gain access to brain tissue via passive diffusion across the barriers. Consequently, many lead drug candidates are disqualified from further development because of poor permeability across the blood-brain barrier. Understanding brain transport processes with the goal of identifying methods that enhance drug delivery across brain barriers.
  • N-Methyl-D-Aspartate Receptors: Explore the pharmacologic modulation of the functional activity and expression of brain N-methyl-D-aspartate receptors (NMDA). Understanding of the neuropharmacology of NMDA receptors may lead to the development of new drugs for disease management.
  • Neuroinflammatory Brain Diseases: Understand the role of neuroinflammatory processes in the progression of chronic neurodegenerative diseases. Since inflammatory processes are a common feature of many neurological diseases (e.g. Alzheimer's disease, multiple sclerosis, HIV-1 dementia, cerebral ischemia, brain tumors and meningitis), an enhanced knowledge of inflammatory mediators and their detrimental effects on the central nervous system provides opportunities for the design of new pharmaceutical approaches in the management of neurological diseases.


Professional Memberships:
  • American Association of Colleges of Pharmacy
  • American Association of Pharmaceutical Scientists
  • American Association for the Advancement of Science
  • Society for Neuroscience
Presentations:
  • "Theoretical Physiologically Based Pharmacokinetic Simulations of Drug Brain Distribution: Implications of Intracarotid versus Systemic Administration for Brain Drug Delivery" AAPS 2011 Annual Meeting, American Association of Pharmaceutical Scientists (2011)
  • "Alteration of Glucose Tolerance and Insulin Regulation by Methylprednisolone (MPL)" AAPS 2010 Annual Meeting, American Association of Pharmaceutical Scientists (2010)
  • "Graduate and Postgraduate Education" , UB Office of Graduate and Postgraduate Education (2010)
  • "Graduate and Postgraduate Education" , UB Office of Graduate and Postgraduate Education (2009)
Service Activities:
  • SWOT Analysis of Pharm Sci BS Program; Authored a SWOT analysis for the Pharm Sci program, as requested by the Dean of the School of Pharmacy; Other (2013)
  • Provost Assessment Report; Developed, collected, analyzed, interpreted data pertaining to the Pharm Sci BS program. Authored a 3 page, mandated Provost Assessment Report. This also required development of a Course Coordinator Self-Evaluation form, which was distributed to and c; Other (2013)
  • ; NIH SBIR Neuropharmacology ZRG1 ETTN-C(11) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each application under discussion.; Other (2013)
  • Teacher of the Year Committee; Evaluation of nominated instructor portfolios and selection of the SoPPS Teacher of the Year.; Member (2013)
  • ; NIH NIDA RFA, DA13-004, “Synthesis & Preclinical Evaluation of Medications to Treat Substance Use Disorder (SUDS) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each applicati; Other (2012)
  • Chemical Hygiene Plan (CHP) Review Committee; Review EH&S's revision of the Chemical Hygiene policy book, to make suggestions and improvements to the revised policies.; Member (2012)
  • UB Honor College Faculty Advisory Board; Member (2012)
  • UB Honors College Council; The UB Honors Council is the body responsible for providing advice and oversight to the Honors College. Attend 3-4 meetings a year; participated in the interview process of prospective Presidential Scholars (1/25/2013); Other (2012)
  • SoPPS Assessment Committee; Member (2012)
  • PHC Program Review; PHC Program Review - responsible for detail relating to the site visit; responsible for the Pharm Sci BS Program section; Coordinator (2012)
  • ; NIH SBIR Neuropharmacology ZRG1 ETTN-C(11) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each application under discussion.; Other (2011)
  • ; NIH SBIR Neuropharmacology ZRG1 ETTN-C(11) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each application under discussion.; Other (2011)
  • SoPPS / Dept of Pharmaceutical Sciences; Liaison for the dept in various matters in coordinating the move to the South Campus.; Other (2011)
  • ; NIH SBIR Neuropharmacology ZRG1 ETTN-C(11) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each application under discussion.; Other (2010)
  • SoPPS ACPE Accreditation; Work with various constituencies within the School of Pharmacy to produce an accreditation report for ACPE as well as coordinate the site visit. Also includes planning and running a 2 day faculty retreat on the Accreditation process and New Curriculum.; Co-Chair (2010)
  • Committee - PHC Graduate Curriculum; Member (2009)
  • Dept Pharmaceutical Sciences Awards Committee; Co-Chair of committee to determing eligible students for departmental awards; Co-Chair (2009)
  • ; NIH SBIR Neuropharmacology ZRG1 ETTN-C(11) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each application under discussion.; Other (2009)
  • Department of Pharmaceutical Sciences; Supervise Ms. Linda Janos, an administrative assistant, until her official retirement from UB.; Other (2008)
  • SBIR NIH Committee; NIH SBIR Neuropharmacology ZRG1 ETTN-C(11) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each application under discussion.; Other (2008)
  • Committee - Graduate PHC Admissions; Review and assess graduate student applications for the BS/MS, MS and PhD Pharmaceutical Science programs; Member (2008)
  • Committee - SoPPS PharmD Admissions; Review and assess electronic admission applications for the PharmD program. Interview and assess students face-to-face using behavioral interviewing techniques.; Other (2008)
  • SBIR NIH Committee; NIH SBIR Neuropharmacology ZRG1 ETTN-C(11) Review and critique Small Business Innovation Grant applications; meet and discuss applications; provide a priority score for each application under discussion.; Other (2008)
  • Committee - SoPPS Executive Committee; Attend and participate on monthy meetings of matters important to the School of Pharmacy.; Member (2002)
  • Department of Pharmaceutical Sciences; Manage academic endeavors of the PHC dept; manage day-to-day problems relating to PHC students and academic affairs; respond to information requests from Decanal and University levels.; Other (2002)
  • Department of Pharmaceutical Sciences; student admissions, student academic review, academic advisement, providing letters of recommendation, updating UB undergraduate catalogue entry for PHC, curriculum review, curriculum updating; Other (1996)
  • Committee - SoPPS Academic Affairs; Review academic performance of all P1-P4 Pharm D students. Reccommend appropriate action consistent with prevailing policies.; Member (1994)

School News:
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Clinical Specialties:
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Contact Information

283 Kapoor Hall
Deans Office
School of Pharmacy
Buffalo, NY 14214-8033
Phone: (716) 645-4829
Email: boje@buffalo.edu


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