Nicholas M. Smith PharmD, PhD

Nicholas Smith

Nicholas M. Smith
PharmD, PhD

Assistant Professor

Department of Pharmacy Practice

School of Pharmacy


Specialty/Research Focus

Clinical Research; Infectious Disease; Pharmacodynamics; Pharmacokinetics; Pharmacometrics; Translational Research

Contact Information
701 Ellicott Street
NYS Center of Excellence
Buffalo, NY 14203
Phone: (716) 881-8215
nmsmith2@buffalo.edu



Professional Summary:

My lab‘s main research focus has been on clinical pharmacology and clinical-translational pharmacometric approaches as it relates to antibiotics and the treatment of extensively resistant and pan resistant bacteria. Our current projects are looking into novel dosing schemes used in the treatment of resistant gram negative ‘superbugs;‘ developing model-based approaches to optimize treatment regimens; and using population studies in tandem with my wet-bench research to better understand what these new therapies mean for patient treatment. As a group of clinician-scientists, our objectives are to design, test, then implement patient- and bacteria-specific treatments in order to optimize patient outcomes.

Education and Training:

  • PhD, University at Buffalo (2021)
  • MS, University at Buffalo (2018)
  • PharmD, University at Buffalo (2018)
  • BS, University at Buffalo (2015)

Research Expertise:

  • Anti-infectives
  • Bacterial Resistance
  • Individualized Therapy

Grants and Sponsored Research:

  • December 2019–November 2024
    Novel Strategies for Antibiotic Combinations to Combat Gram-negative Superbugs
    NIH/NIAID
    Role: Co-Investigator
    $3,920,000
  • November 2021–November 2023
    Treatment Individualization in a Post-Antibiotic Era for Special Patient Populations
    NIH/DLR/NIAID
    Role: Principal Investigator
    $89,000
  • August 2018–July 2023
    Age and Race Influences on Immunosuppression after Renal Transplant
    NIH/NIA
    Role: Co-Investigator
    $3,500,000
  • October 2021–November 2021
    AIDS Clinical Trials Group Pharmacology Specialty Laboratory (subaward 1650GYA545)
    NIH/NIAID
    Role: Co-Investigator

Journal Articles:


Presentations:

  • "Assessing the Antimicrobial Pharmacodynamics of Bacteriophages to Develop Next Generation Dosing Strategies" World Microbe Forum, American Society of Microbiology (2021)
  • "Rationally Optimizing Therapeutic Combination Therapies Against Multiple Clinical Klebsiella pneumoniae Isolates Co-expressing New Delhi-Metallo-β-lactamase (NDM) and CTX-M" ECCMID (2021)
  • "Resistance is Futile: Profiling the in vivo Response of New Delhi Metallo-β-lactamase (NDM) and CTX-M-co-producing Klebsiella pneumoniae to Antibiotic Combinations." ECCMID (2021)
  • "Development of ‘Advanced Dosing Solutions’, a Freely Available and Customizable Solution to Providing maximum a posteriori-Bayesian Dosing" World Microbe Forum, ASM (2021)
  • "Overthrowing Antibiotic Resistance In Metallo-beta-lactamase Gram-negatives" World Microbe Forum, ASM, Antibiotic Agents and Resistance (2021)
  • "New Combinations against NDM-Producing Klebsiella pneumoniae: A Modeling Approach for Pharmacodynamic Optimization" ASM Microbe, American Society of Microbiology, Antibiotic Agents and Resistance (2019)
  • "Survival of the Fittest: Using a Genetic Algorithm to Find Improved Combination-Dosing Strategies against Carbapenem-resistant Acinetobacter baumannii in Critically Ill Patients" Fellowship Forum (2019)
  • "Systems Approaches to Combat Microbial Resistance," ASM North East Regional Meeting, ASM (2018)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

701 Ellicott Street
NYS Center of Excellence
Buffalo, NY 14203
Phone: (716) 881-8215
nmsmith2@buffalo.edu