Professional Memberships:

• International Pharmaceutical Federation (2012)
• American Association for Cancer Research (2012)
• International Society of Pharmacometrics (2011)
• American Association of Colleges of Pharmacy (2005)
• Association of Colleges of Pharmacy (2005–present)
• American Society for Pharmacology and Experimental Therapeutics (2004)
• American College of Clinical Pharmacology (2004)
• American College of Clinical Pharmacology (2004–present)
• American Society for Pharmacology and Experimental Therapeutics (2004–present)
• American Society for Clinical Pharmacology and Therapeutics (2003)
• American Association for the Advancement of Science (2003)
• American Association for the Advancement of Science (2003–present)
• American Society for Clinical Pharmacology and Therapeutics (2003–present)
• American Association of Pharmaceutical Scientists - UB Student Chapter; 1999-2002 Chair (Sept. 2000-Sept. 2001), Vice-Chair (Sept. 1999-Sept. 2000) (1999–2001)
• Graduate Student Association Department of Pharmaceutical Sciences; Chair (May 1999 - May 2000) (1999–2002)
• Graduate Student Association; Chair (5/99 - 5/00) (1999)
• American Association of Pharmaceutical Scientists (1999)
• American Association of Pharmaceutical Scientists (1999–present)

Presentations:

• "Integrated Network and Systems Pharmacology Modeling and US Initiatives" EUFEPS Workshop: Systems Pharmacology - Towards a European Network?, EUFEPS (2013)
• "Pharmacodynamic Modeling of Heart Rate Variability (HRV) and Vagal Tone" ACOP Annual Meeting, ISOP (2013)
• "Semi-Mechanistic Population Pharmacokinetic Approaches for ADCs" Short-course: ADCs in Clinical Development: Initiating Phase I and Beyond, AAPS NBC (2013)
• "Utilizing Semi-mechanistic Pharmacokinetic Models for Improved ADC Development" AAPS NBC Annual Meeting, AAPS (2013)
• "Translational Pharmacodynamic Modeling of Combinatorial Therapy in Oncology" , University of Toronto (2013)
• "PK/PD Aspects of Targeted Covalent Drugs" Delaware Valley Drug Metabolism Discussion Group Meeting, DVDMDG (2013)
• "Theoretical, Translational and Technical Capabilities in Applying Quantitative Approaches to Combination Therapy" ASCPT Annual Meeting, ASCPT (2013)
• "Translational Pharmacodynamic Modeling of Combinatorial Therapeutic Systems" Pre-Conference: Quantitative Systems Pharmacology: An Integrating Framework for Translational Medicine, ASCPT (2013)
• "Computational Coupling of Signal Transduction and Pharmacodynamic Systems" Workshop: Systems Pharmacology for the Prediction of Tyrosine Kinase Inhibitor non-QT Cardiotoxicity, Co-convened by Reagan-Udall Foundation & Food and Drug Administration (2013)
• "Pharmacometric Analysis of Nanoparticulate and Antibody-Based Anti-Cancer Agents" , National Institute for Cellular Biotechnology, Dublin City University (2012)
• "PK/PD Systems Analysis of Biologics" PKUK Annual Meeting, PKUK (2012)
• "Translational PK/PD Analysis of Nanoparticulate and Antibody-Based Anti-Cancer Agents" Indiana Clinical and Translational Sciences Institute Symposium on Disease and Therapeutic Response Modeling, University of Indiana (2012)
• "Scaling Pharmacodynamics from In Vitro and Preclinical Animal Studies to Humans" AAPS Annual Meeting, AAPS (2012)
• "Applications of Quantitative Pharmacology: PK/PD M&S for Identifying Optimal Biologic Dose" ACCP Annual Meeting, ACCP (2012)
• "Potential Mechanisms of Drug-Drug Interactions with Therapeutic Proteins" ACCP Annual Meeting, ACCP (2012)
• "Pharmacokinetic/pharmacodynamic modeling of cocaine self-administration behavior in rats" 74th Annual Meeting - College on Problems of Drug Dependence, The College on Problems of Drug Dependence (CPDD) (2012)
• "Towards Integrating Systems Pharmacology and Pharmacodynamic Modeling in Oncology" Applications of Systems Biology to Drug Discovery & Development, Roche (2012)
• "Translational Pharmacometrics: Integration of Systems Pharmacology and PK/PD Modeling" Pharmacometrics: Modeling and simulation in Drug Development, Center for Human Experimental Therapeutics, University of Rochester Medical Center (2012)
• "Pharmacokinetics & Pharmacodynamics of Biological Therapeutics" Msc Program, University of Manchester (2012)
• "Mathematical Analysis of Paclitaxel-induced Tumor Priming That Leads to Enhanced Deposition and Efficacy of Nanoparticulate Doxorubicin" American Association for Cancer Research, AACR (2012)
• "Probing Drug Exposure-Response Relationships in Inflammatory Bone Loss with Translational Pharmacodynamic Systems Modeling" Bridging Bench and Bedside with Quantitative Model-Based Translational Pharmacology, NYAS (2012)
• "Towards Enhanced Pharmacodynamic Modeling in Oncology" , University at Buffalo, SUNY (2012)
• "Cell Signaling Model of CD20 Agonism for Predicting Efficacy of Combination Chemotherapy for non-Hodgkins Lymphoma" , University of Kentucky (2012)
• "Introduction to Pharmacodynamic Principles" ACDRS Workshop Session 2: Learning Trials: From Discovery to First in Humans, UCSF (2012)
• "Network-based Analysis for Enhancing PK/PD Modeling in Oncology" Indiana Clinical and Translational Sciences Institute Symposium on Disease and Therapeutic Response Modeling, University of Indiana (2011)
• "Conceptual Framework of Models Used for PK/PD Modeling of Biologics" AAPS Annual Meeting, AAPS (2011)
• "PK/PD Systems Analysis: Hands-on Modeling with ADAPT5" AAPS Annual Meeting, AAPS (2011)
• "Translation of Pharmacodynamics: Concepts and Examples" ISSX 17th North American Meeting, ISSX (2011)
• "PK/PD Systems Analysis in Translational Research" Applied Pharmaceutical Analysis Annual Meeting, APA (2011)
• "Bridging PK/PD and Systems Pharmacology Modeling in Oncology" Gordon Research Conference on Drug Metabolism, GRC (2011)
• "Probing Drug Exposure-Response Relationships Through Translational PK/PD Modeling" 2nd Annual PaSiPhIC, PaSiPhIC (2011)
• "Pharmacodynamic Modeling of Biomarkers in Drug Development" AAPS NBC, AAPS (2011)
• "Pharmacokinetics & Pharmacodynamics of Biological Therapeutics" Msc Program, University of Manchester (2011)
• "Target-mediated Drug Disposition Models: Theory and Parameterization" AAPS NBC, AAPS (2011)
• "CD20 Receptor Occupancy-driven Cell Signaling Model for Predicting in vivo Combination Chemotherapy" Seminar, Mount Sinai School of Medicine (2011)
• "Chemotherapy and Translational PK/PD Modeling" Seminar, Merrimack Pharmaceticals (2011)
• "Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies" 4th APISSX, APISSX (2011)
• "Introduction to Pharmacodynamic Principles" ACDRS Workshop Session 2: Learning Trials: From Discovery to First in Humans, UCSF (2011)
• "Theoretical Considerations of the Target-Mediated Disposition of Therapeutic mAbs" ASCPT Annual Meeting, ASCPT (2011)
• "Small Systems Models for Bridging Exposure-Response Relationships" Drug Safety Workshop: Pharmacological Mechanism-Based Drug Safety Assessment and Prediction, FDA (2011)
• "Basic Concepts of PK/PD Modeling and Translational Pharmacology" Model-Based Drug Development Workshop, Johnson & Johnson (2010)
• "Towards Integrating Systems Pharmacology and PK/PD Models" Conference Call, Pfizer (2010)
• "Modeling and Simulation to Develop Therapeutic Proteins" Annual Meeting of the American College of Clinical Pharmacology, American College of Clinical Pharmacology (2010)
• "Occupancy-driven Cell Signaling Model of CD20 Agonists to Predict Combination Chemotherapy in Mice" Quantitative and Systems Pharmacology Workshop II, NIH (2010)
• "Overview of the Importance of Drug Interactions with Biologics" 13th Annual Land O'Lakes Conference (2010)
• "Whither Systems Pharmacology Modeling?" University at Buffalo, SUNY, Department of Pharmaceutical Sciences (2010)
• "Pharmacokinetics and Exposure-Response Relationships of Biologics" Delaware Valley Drug Metabolism Discussion Group (2010)
• "Pharmacodynamic Modeling of Anticancer Agents" Advancing New Therapeutics to Clinical Trials Workshop, SUNY Upstate Cancer Research Institute (2010)
• "Pharmacokinetics & Pharmacodynamics of Biological Therapeutics" Msc Program, University of Manchester (2010)
• "Model-Based Approaches for Metabolic Disorders" KSCPT-ASCPT Joint Conference, KSCPT and ASCPT (2009)
• "PK/PD Modeling and Simulation: History and Basic Principles" Workshop: PK/PD Modeling in Drug Discovery and Translational Research: A Building Block for Quantitative Model-based Drug Development, AAPS (2009)
• "Postdoctoral Positions in Academia and the NIH" AAPS Annual Meeting, AAPS (2009)
• "Scaling Pharmacokinetics/Pharmacodynamics from Animal Studies to Humans" AAPS Annual Meeting, AAPS (2009)
• "Applications of Modeling over the Development Life Cycle of Biologics" American Conference on Pharmacometrics, ACoP (2009)
• "Overview of Pharmacokinetics and Pharmacodynamics of Biologics" ISSX Annual Meeting, ISSX (2009)
• "Novel Biomarkers and Disease Models: Why?" ACCP Annual Meeting, ACCP (2009)
• "Role of Target and Mechanism Biomarkers in Translational Research" AAPS Clinical Pharmacology and Translational Research Webinar, AAPS (2009)
• "Basic Principles and Approaches to Predicting FIH Doses for MAbs" AAPS National Biotechnology Conference, AAPS (2009)
• "Integrated Bone Homeostasis Model for Denosumab Pharmacodynamics in Multiple Myeloma" , Pfizer, Inc (2009)
• "Model-Based Approaches for Metabolic Disorders" , Bristol-Myers Squibb (2009)
• "Model-Based Approaches for Metabolic Disorders and Biologic Therapeutics" MOSAIC (2009)
• "Preclinical PK/PD Modeling of Anticancer Agents" UB - Pfizer Strategic Alliance Annual Meeting, Pfizer, Inc (2009)
• "Receptor-Mediated Drug Disposition of Recombinant Native Interferon-á in Wild-type and Interferon à/áR-/- Knockout Mice" AAPS National Biotechnology Conference, American Association of Pharmaceutical Scientists (2009)
• "Role of Target and Mechanism Biomarkers in Translational Research" AAPS National Biotechnology Conference, AAPS (2009)
• "Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Biologics" Current Topics in Drug Metabolism and Pharmacokinetics: Biologics and Transporters - What's New?, North Jersey ACS Drug Metabolism Discussion Group (2009)
• "Mechanistic Pharmacokinetic/Pharmacodynamic Models" Clinical Pharmacology Review Course, American Society of Clinical Pharmacology and therapeutics (2009)
• "Population Modeling of Hyperglycemic Clamp and Meal Tolerance Tests in Patients with Type 2 Diabetes Mellitus" ASCPT Annual Meeting, American Society of Clinical Pharmacology and therapeutics (2009)
• "Integrating Pharmacodynamics into Models of Target-Mediated Drug Disposition" 3rd Roche-Novartis Modeling & Simulation Meeting, Novartis (2009)
• "Exposure-Response Modeling of Calcium Receptor Antagonist Mediated Stimulation of Parathyroid Hormone Secretion in Rats using an Allosteric Receptor-Binding Model" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2008)
• "Physiologically-Based Pharmacokinetic Modeling of Neutral and Charged Nanocomposite Devices in Mice" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2008)
• "Selection Between Michaelis-Menten and Target-Mediated Drug Disposition Pharmacokinetic Models" AAPS Annual Meeting, AAPS (2008)
• "Validity of the Rapid Binding Approximation of a Target-Mediated Drug Disposition Model" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2008)
• "Basic Principles in Pharmacology" Ehrlich II - 2nd World Conference on Magic Bullets (2008)
• "PK-PD Modeling of Aliskiren Effects on Biomarkers of the Renin-Angiotensin System in Humans" Ehrlich II - 2nd World Conference on Magic Bullets (2008)
• "Biomarkers: An Overview" 11th Annual Land O'Lakes Conference on Drug Metabolism/Applied Pharmacokinetics (2008)
• "Predicting Pneumonia Scores using an Antimicrobial Drug Exposure/Sensitivity Index and an Artificial Neural Network" 4th International Symposium on Resistant Gram-Positive Infections (2008)
• "Binding to the Target Ligand: Monoclonal Antibody PK/PD First Principles (Berkeley Madonna Hands-on)" Short Course, AAPS National Biotechnology Conference (2008)
• "Chemotherapy PK/PD Modeling" UB-Pfizer Annual Research Symposium, Pfizer (2008)
• "Integrated Bone Homeostasis Model for Denosumab Pharmacodynamics in Multiple Myeloma" Workshop on New Prospects for Cancer Immunotherapy: Integrating Biomarkers in Mathematical Models, Institute for Medical BioMathematics (2008)
• "Integrated cellular bone homeostasis model for denosumab pharmacodynamics in multiple myeloma patients" Experimental Biology, American Society of Pharmacology and Experimental therapeutics (2008)
• "Mapping the relationship between clinical response and an antimicrobial drug exposure/sensitivity index using a neural network" ASCPT Annual Meeting, American Society of Clinical Pharmacology and Therapeutics (2008)
• "Mechanism based pharmacokinetic/pharmacodynamic model of parathyroid hormone-calcium homeostasis in rats and humans" ASCPT Annual Meeting, American Society of Clinical Pharmacology and therapeutics (2008)
• "Comparison of the performance of likelihood-based methods implemented in NONMEM and MC-PEM/S-ADAPT to account for pharmacokinetic data below the lower limit of quantification" American Conference on Pharmacometrics (2008)
• "Target-Mediated Disposition of Monoclonal Antibodies: Implications for Mab Development" Groupe de M‚tabolisme et de Pharmacocin‚tique (GMP) (2008)
• "Mathematical Properties of a Quasi-Equilibrium Model of Target-Mediated Drug Disposition" AAPS Annual Meeting (2007)
• "Pharmacokinetic/Pharmcodynamic Implications of Receptor Dimerazation and Specific Tissue Distribution in Target-Mediated Drug Disposition Models" AAPS Annual Meeting (2007)
• "Mechanistic Pharmacokinetic/Pharmacodynamic Models" , Eisai (2007)
• "Dose versus Response Relationships" , Wyeth (2007)
• "Binding to the Target Ligand: PK/PD of Monoclonal Antibodies" Sunrise Session, AAPS National Biotechnology Conference (2007)
• "Chemotherapy PK/PD Modeling" UB-Pfizer Annual Research Symposium, Pfizer (2007)
• "Mechanistic Pharmacokinetic/Pharmacodynamic Models" Clinical Pharmacology Review Course, American Society of Clinical Pharmacology and therapeutics (2007)
• "Local parameter sensitivity analysis of selected target-mediated pharmacokinetic models" AAPS Annual Meeting (2006)
• "Receptor & Target Binding Models" Course in Pharmacokinetic/Pharmacodynamic Modeling, American College of Clinical Pharmacology (2006)
• "Quantitative Structure-Pharmacokinetic Relationships (QSPKR) using Bayesian Neural Networks" oint SIAM/SMB Conference on the Life Sciences, SIAM (2006)
• "Approaches to Mechanism-Based PK/PD Modeling in Pediatric Pharmacology" Pediatric Pharmacology and Therapeutics, PPRU NSC Meeting, National Institutes of Health (2006)
• "Role of Molecular Structure in Determining Pharmacokinetics and Pharmacodynamics" UB-Pfizer Annual Research Symposium, Pfizer (2006)
• "Target-Mediated Drug Disposition and Dynamics" , University of Georgia (2006)
• "Modeling Receptor-Mediated PK/PD Systems" , University at Buffalo, SUNY (2006)
• "K-PD Modeling of Exendin-4 Pharmacodynamics" , Cognigen (2006)
• "Target-Mediated PK/PD Modeling of Biotechnology Pharmaceuticals" , University at Buffalo, SUNY (2005)
• "Application of PK/PD Modeling to Expedite the Discovery and Development of Monoclonal Antibodies to Alter Cell Function" , AAPS National Biotechnology Conference (2005)
• "PK/PD Modeling of Target-Mediated Drug Disposition and Dynamics" 11th BMSR Workshop on Advanced Methods of PK/PD Systems Analysis, University of Southern California (2005)
• "Application of Non-Deterministic Systems in Clinical Pharmacology" , University at Buffalo, SUNY (2004)

Service Activities:

• Mentoring Committee; Member (2013)
• SPPS Assessment Committee; Member (2013)
• Edward Mallinckrodt Jr. Foundation Ad hoc Committee; Member (2013)
• SPPS Dean Search Committee; Member (2012)
• PCC Committee; American Association of Pharmaceutical Sciences; Member (2012)
• Annual Meeting Abstract Screening Committee; ACCP; Reviewer (2012)
• Annual Meeting Planning Committee; ACCP; Other (2012)
• Pre-Conference Workshop Planning Committee; ASCPT; Other (2012)
• Scientific Advisory Board; Certara; Other (2012)
• Board of Directors; ISOP; Other (2012)
• American Conference on Pharmacometrics; ISOP; Other (2012)
• AAPS Nominations Committee; American Association of Pharmaceutical Sciences; Member (2011)
• Associate Dean Search Committee; Member (2011)
• Clinical Pharmacology and Translational Research Section; American Association of Pharmaceutical Sciences; Other (2011)
• Special Interest Group; FIP; Other (2011)
• Clinical Pharmacology and Translational Research Section; American Association of Pharmaceutical Sciences; Other (2010)
• Curriculum Committee; Member (2010)
• Decanal Grievance Committee; Member (2010)
• ACPE Accreditation Self-Study Subcommittee; Member (2010)
• Clinical Pharmacology and Translational Research Section; American Association of Pharmaceutical Sciences; Other (2009)
• Scientific Advisory Board; University of Iowa; Other (2009)
• Scientific Advisory Board; Biomedical Simulations Resource, USC; Member (2009)
• Pharmaceutical Sciences Graduate Admissions Committee; Member (2008)
• AAPS NewsMagazine Content Advisory Committee; American Association of Pharmaceutical Sciences; Member (2008)
• Center for Protein Therapeutics Management Committee; Member (2008)
• Clinical Pharmacology Advisory Committee; Food and Drug Administration; Member (2008)
• Pharmaceutics Graduate Student Awards Committee; Chair, December 2008; Member (2006)
• Pharmaceutical Sciences Seminar; Other (2006)
• Pharmaceutical Sciences Faculty Search Committee; Member (2006)
• Doctor of Pharmacy Admissions Committee; Member (2004)
• 3rd Annual Post-Doctoral Research Symposium; Reviewer
• AAPS Biotech 101 Lecturer; American Association of Pharmaceutical Sciences; Other
• AAPS Graduate Symposium Awards in CPTR/PPDM Committee; American Association of Pharmaceutical Sciences; Other
• AAPS Symposium Organizer and Moderator; American Association of Pharmaceutical Sciences Systems Pharmacology for the Assessment and Prediction of Adverse Drug Effects; Other
• Buffalo Pharmaceutical Sciences Symposium; Organized and conducted 2.5-day Conference; Other
• Community Outreach Activity; CHEMSHARE Hosted CHEMSHARE visit to the Department of Pharmaceutical Sciences, University at Buffalo, SUNY, with the goal of introducing pharmaceutical sciences to local high school chemistry and physics educators.; Other
• School of Pharmacy & Pharmaceutical Sciences Retreat Committee; Volunteer