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William                        Jusko

William J. Jusko PhD

Department of Pharmaceutical Sciences

SUNY Distinguished Professor

Specialty/Research Focus

Pharmacodynamic; Pharmacogenomics; Pharmacokinetic; PK/PD

 
Professional Summary:

Research interests are in theoretical, basic, and clinical aspects of the pharmacokinetics and pharmacodynamics of various immunosuppressive agents including corticosteroids, as well as drugs used to treat diabetes, inflammation, and cancer. With Drs. Richard Almon and Debra DuBois, Dr. Jusko delves into the pharmacogenomics of diverse effects of corticosteroids and has evolved advanced mathematical models of receptor/gene-mediated responses. They have characterized the effects of corticosteroids on hepatic and muscle enzymes and tissue responses and have evolved advanced PK/PD models for cascade-type processes. Dr. Jusko has developed mechanism-based pharmacokinetic, pharmacodynamic, and disease progression models and computational methods describing the action of various drugs and utilizes mathematical models of drug action to determine optimal dosage regimens diverse drugs.

Education and Training:
  • PhD, Pharmaceutical Sciences, State University of New York at Buffalo (1970)
  • BPharm, State University of New York at Buffalo (1965)
  • Secondary Education High School Diploma, Salamanca High School (1960)
Employment:
  • SUNY Distinguished Professor, Pharmaceutical Sciences, University at Buffalo (2008-present)
  • Director, Center of Excellence in Pharmacokinetics and Pharmacodynamics, Pharmaceutical Sciences, University at Buffalo (2005-present)
  • Chair, Department of Pharmaceutical Sciences, University at Buffalo (2001–2016)
  • UB Distinguished Professor, Department of Pharmaceutical Sciences, University at Buffalo (2007–2008)
  • Professor, Pharmaceutical Sciences, University at Buffalo (1977–2007)
  • Vice-Chairman, Department of Pharmacy, Department of Pharmacy, University at Buffalo (1984–1986)
  • Director, Doctor of Pharmacy Program, Pharmacy, University at Buffalo (1981–1986)
  • Director, Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital (1972–1981)
  • Visiting Scientist, Mario Negri Institute for Pharmacology, Italy (1978–1979)
  • Associate Professor of Pharmaceutics, Pharmaceutical Sciences, University at Buffalo (1974–1977)
  • Assistant Professor of Pharmaceutics, Pharmaceutical Sciences, University at Buffalo (1972–1974)
  • Assistant Professor of Pharmacology, Pharmacology, Boston University School of Medicine, Boston University School of Medicine (1970–1972)
  • Research Associate, Boston Collaborative Drug Surveillance Program, Boston University, Boston University Medical Center (1969–1972)
  • Research Pharmacologist, Veterans Administration Hospital Boston (1969–1972)
  • Research Assistant Dept. of Pharmaceutics, University at Buffalo (1962–1969)
  • Pharmacist, Soby's Pharmacy (1966–1968)
  • Hospital Pharmacist, Children's Hospital of Buffalo (1962–1966)
See all (7 more)
Awards and Honors:
  • Advisor: AAPS Graduate Student Award in PPDM - Xu Zhu and Xi (Cindy) Chen (2015)
  • Doctor Honoris Causae, University of Paris Descartes (2015)
  • Collegium of Eminent Scientists, Kosciuszko Foundation (2015)
  • ASCPT Sheiner-Beal Pharmacometrics Award (2013)
  • Advisor: AAPS Graduate Student Award in PPDM - Hoi Kei Lon (2012)
  • Distinguished Investigator Award ACCP (2012)
  • ACoP Leadership Award (2011)
  • AAPS Meritorious Manuscript Award (2008)
  • Paul Ehrlich Magic Bullet Lifetime Achievement Award (2008)
  • UB Distinguished Professor (2007)
  • Swintosky Distinguished Lecturer - UKY (2006)
  • Volwiler Research Achievement Award - AACP (2005)
  • MERIT Award - NIH (2005)
  • Roland T. Lakey Award Lecture - WS (2003)
  • ISI Most Highly Cited List in Pharmacology (2003)
  • Chancellor‘s Award for Research -UB (2003)
  • Sustained Achievement Award - UB (2002)
  • John G. Wagner Lectureship - UM (1999)
  • Research Achievement Award - PPDM, AAPS (1998)
  • Kosciusko Award - Buffalo (1996)
  • Distinguished Service Award - ACCP (1989)
  • Russell R. Miller Award - ACCP (1988)
  • Doctor Honoris Causae, Jagiellonian University, Krakow (1987)
  • Citizen of the Year - Buffalo (1987)
  • Rawls-Palmer Award - ASCPT (1987)
  • Fellow- AAPS (1986)
  • Fellow - ACCP (1986)
  • Fellow - AAAS (1985)
  • Rorer Award - AJG (1980)
  • Fellow - ACS (1980)
  • Fulbright-Hays Award to lecture/research in Milan, Italy (1978)

Research Expertise:
  • Pharmacodynamics: Pharmacogenomics of diverse effects of corticosteroids and the development of models of receptor/gene-mediated responses
  • Pharmacokinetics and Pharmacodynamics: Theoretical, basic, and clinical aspects of the PK/PD of immunosuppressive agents including corticosteroids, sirolimus, and tacrolimus
Grants and Sponsored Research:
  • August 2015–August 2019
    Buffalo Clinical and Translational Research Center Clinical and Translational Science Award(CTSA)
    National Center for Advancing Translational Sciences (NCATS)/National Institutes of Health
    Role: Co-Investigator
    $20,000,000
  • July 2015–June 2019
    Corticosteroid Pharmacokinetics and Pharmacodynamics
    NIH/NIGMS
    Role: Principal Investigator
    $2,392,890
  • September 2014–August 2017
    Physiologically-Based Pharmacokinetic Model for Drugs Encapsulated into Liposomes
    NIH/FDA
    Role: Co-Investigator
    $639,400
  • September 2011–August 2016
    Molecular and Clinical Pharmacology of Retinopathy of Prematurity
    NIH/NICHHD
    Role: Co-Investigator
    $79,020
  • June 2012–August 2013
    Pharmacokinetics and Relative Bioavailability of Liquid Formulation of Hydroxyurea in Pediatric Patients with Sickle Cell Anemia
    Duke University
    Role: Principal Investigator
    $19,439
Patents:
  • Novel Method of Treatment (1999)

Evaluative Studies and Case Reports:
Journal Articles:
See all (231 more)
Abstracts:
  • Morse ED; Janicke DM; Cafarell RF; Walshe JJ; Venuto RC; Apicella MA; Jusko WJ. Pharmacokinetics of intraperitoneal moxalactam in CAPD. Drug Intelligence & Clinical Pharmacy. 1984; 18.
Books and Book Chapters:
  • Jusko WJ. Foundations of Pharmacodynamic Systems Analysis (Chapter 8). Systems Pharmacology and Pharmacodynamics, AAPS Advances in the Pharmaceutical Sciences Series 23. 2016.
  • Cao Y Jusko WJ. Mechanistic Physiologically Based Pharmacokinetic Models in Development of Therapeutic Monoclonal Antibodies (Chapter 12). ADME and Translational PK/PD of Therapeutic Proteins. 2015; Chpt(12).
  • Sukumaran S; Dubois DC; Jusko WJ; Almon RR. Glucocorticoid Effects on Adiponectin Expression in Adiponectin (Chapter 7). Adiponectin, Vitamins & Hormones Series. 2012; 90.
  • Mager DE; Jusko WJ. Mechanistic Pharmacokinetic/Pharmacodynamic Models II (Chapter 23). Pharmacometrics, The Science of Quantative Pharmacology. 2007.

Professional Memberships:
  • Phi Lambda Sigma Pharmacy Leadership Society (2002–present)
  • European Federation for Pharmaceutical Sciences (1999–2000)
  • American College of Clinical Pharmacology (1989–present)
  • American Association of Pharmaceutical Scientists (1986–present)
  • American College of Clinical Pharmacy (1980–present)
  • Federation Internationale Pharmaceutique (1980–present)
  • American Society for Clinical Pharmacology and Therapeutics (1976–present)
  • American Society for Microbiology (1975–1994)
  • American Society for Pharmacology and Experimental Therapeutics (1974–present)
  • American Association of Colleges of Pharmacy (1972)
  • American Association for the Advancement of Science (1970–present)
  • Academy of Pharmaceutical Research and Science (1969–present)
  • Rho Chi Pharmaceutical Honor Society (1968)
  • Kappa Psi Pharmaceutical Fraternity (1962–1965)
  • American Pharmaceutical Association (1962–present)
See all (5 more)
Presentations:
  • "3-day Buffalo Post-Graduate Course on Pharmacokinetics and Pharmacodynamics" 3-day Buffalo Post-Graduate Course on Pharmacokinetics and Pharmacodynamics (2016)
  • "Multiscale PD Studies of Drug Combination Between Gemcitabine & Trabectedin for the Treatment of Pancreatic Cancer. Scale III. Dynamic Proteomic Responses of Pancreatic Cancer Cells Druing Combination Exposures to Gemcitabine & Trabectedin" Roche ‘Increasing Drug Development Success Through Quantitative Systems Pharmacology’, NY Academy of Sciences Symposium (2015)
  • "Multiscale Pharmacodynamic (PD) Studies of Drug Combination Between Gemcitabine & Trabectedin for the Treatment of Pancreatic Cancer. Scale II. Mathematical Models of Cell Cycle Distribution of Gemcitabine, Trabectidin & Combinations on Pancreatic Cancer" Roche ‘Increasing Drug Development Success Through Quantitative Systems Pharmacology’, New York Academy of Sciences Symposium (2015)
  • "Network Analysis of Proteomics of Gemcitabine and Birinapant Combinations in Apoptosis Signaling of Pancreatic Cancer Cells" Roche ‘Increasing Drug Development Success Through Quantitative Systems Pharmacology’, New York Academy of Sciences Symposium (2015)
  • "Dynamic Proteomic Responses of Pancreatic Cancer Cells During Combination Exposures to Gemcitabine and Ecteinascidin ET 743" American Association of Pharmaceutical Scientists (2015)
  • "Mechanistic Modeling of Tissue-Specific Receptor/Gene-Mediated Pharmacodynamic Effects of Corticosteroids and Role of Circadian Rhythms on GILZ mRNA Expression" American Association of Pharmaceutical Scientists (2015)
  • "Minimal Physiologically-Based Pharmacokinetic (mPBPK) Model for a Monoclonal Antibody (mAb) against Interleukin-6 in Mice with Collagen-Induced Arthritis (CIA)”" American Conference on Pharmacometrics (2015)
  • "Multiscale Pharmacodynamic Studies of Gemcitabine and Trabectedin Combinations for Treatment of Pancreatic Cancer" Department of Pharmaceutical Sciences, 323266818 (2015)
  • "Network Analysis of Proteomics of Gemcitabine and Birinapant Combinations in Pancreatic Cancer Cells" American Association of Pharmaceutical Scientists (2015)
  • "Pharmacodynamics of Suppression of Free TNF-a by Infliximab in Plasma of Rats" American Association of Pharmaceutical Scientists (2015)
  • "What We Do in Pharmaceutical Sciences" University of Buffalo - PharmD IPPE program, 323266818 (2015)
  • "Moving From Basic PK/PD Towards Systems Pharmacology: Whither Pediatrics?" T32 Programs in Pediatric Clinical Pharmacology, National Institute of Child Health and Human Development (2015)
  • "Moving From Basic Towards Systems Pharmacodynamic Models" Faculte de Pharmacie de Paris, Universite Paris Descartes (2015)
  • "Inclusion of Tissue Target Dynamics in Minimal PBPK Models for mAb PK/PD" Seventh Annual Symposium, Center for Protein Therapeutics, 323266818 (2015)
  • "Suppression of Free TNF-a With Infliximab in Plasma and Joints in CIA Rats" Seventh Annual Symposium, Center for Protein Therapeutics, 323266818 (2015)
  • "3-day course on Pharmacokinetic-Pharmacodynamic Modeling" Merck Pharmaceuticals (2015)
  • "Transitioning From Basic PK/PD To Systems Pharmacology" NJ/PA Branch of the International Society for Pharmacometrics (2015)
  • "Effects of Altered FcgR Expression by Dexamethasone on Monoclonal Antibody Pharmacokinetics in Rats with Rheumatoid Arthritis" 7th Annual Postdoc Research Symposium, 323266818 (2015)
  • "Annual 3-day Buffalo Post-Graduate Course on Pharmacokinetics and Pharmacodynamics" Annual 3-day Buffalo Post-Graduate Course on Pharmacokinetics and Pharmacodynamics (2015)
  • "PBPK Modeling of Etanercept Biodistribution in Arthritic Rats" Department of Pharmaceutical Sciences, 323266818 (2015)
  • "Two-Day Buffalo Workshop on Systems Pharmacology" Two-Day Buffalo Workshop on Systems Pharmacology, 323266818 (2015)
  • "Network Analysis of Proteomics of Gemcitabine and Birinapant Combinations in Apoptosis Signaling of Pancreatic Cancer Cells" UB Sigma Xi Poster Day, 323266818 (2015)
  • "Network Modeling of Gemcitabine and Birinapant Proteomics in Pancreatic Cancer Cells" Department of Pharmaceutical Sciences, 323266818 (2015)
  • "Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model" AAPS Annual Meeting and Exposition (2014)
  • "Biodistribution of Etanercept to Tissues and Sites of Inflammation in Arthritic Rats" American Association of Pharmaceutical Scientists (2014)
  • "Incorporating Target-Mediated Drug Disposition in a Minimal Physiologically-Based Pharmacokinetic Model for Monoclonal Antibodies" AAPS Annual Meeting and Exposition (2014)
  • "Mechanism-Based Drug Interactions of Gemcitabine and Birinapant in Pancreatic Cancer Cells" AAPS Annual Meeting and Exposition (2014)
  • "Second-Generation Minimal Physiologically-Based Pharmacokinetic Model for Monoclonal Antibodies" American Association of Pharmaceutical Scientists (2014)
  • "Department Highlights” and “Moving from Basic towards Systems Pharmacodynamic Models" Thirteenth Buffalo Pharmaceutics Symposium, 323266818 (2014)
  • "Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model" Thirteenth Buffalo Pharmaceutics Symposium, 323266818 (2014)
  • "Mechanism-Based Interaction Model of Gemcitabine and Ecteinascidin (Et-743) in Pancreatic Cancer Cells" Thirteenth Buffalo Pharmaceutics Symposium, 323266818 (2014)
  • "Mechanism-Based Drug Interactions of Gemcitabine and Birinapant in Pancreatic Cancer Cells" Thirteenth Buffalo Pharmaceutics Symposium, 323266818 (2014)
  • "Second-Generation Minimal PBPK Model for mAb Pharmacokinetics" 6th Annual Symposium Center for Protein Therapeutics, 323266818 (2014)
  • "3-day Course on Pharmacokinetics and Pharmacodynamics" University of Gdansk (2014)
  • "Minimal Physiologically-Based Pharmacokinetic Modeling of Monoclonal Antibodies" Servier Inc. (2014)
  • "Pharmacokinetics and Pharmacodynamics & Systems Pharmacology" Annual 4-day Buffalo Course on Pharmacokinetics and Pharmacodynamics & Systems Pharmacology (2014)
  • "PK/PD Modeling: Lessons from Corticosteroids" Medical University of Gdansk (2014)
  • "Workshop on Pharmacodynamics and Systems Pharmacology at Dublin City University" Dublin City University (2014)
  • "PK/PD Modeling of Anti-Infective Drugs" Hoffman LaRoche (2014)
  • "An Extensive and Reproducible Ion-Current-Based Method Enabled Large-Scale Proteomic Assessment of Corticosteroid Treatment in 60 Animals" American Association of Pharmaceutical Scientists (2013)
  • "Mechanism-Based Drug Interaction Model of Gemcitabine and Ecteinascidin (Et-743) in Pancreatic Cancer Cells" American Association of Pharmaceutical Scientists (2013)
  • "PK/PD Modeling in Inflammation" Department of Oral Biology, 323266818 (2013)
  • "Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy" Annual Meeting of the Child Neurology Society (2013)
  • "Profiling Diabetes Disease Progression in GK Rats and Intervention with Salsalate" American Association of Pharmaceutical Scientists (2013)
  • "Applications of Minimal PBPK Models in mAb Pharmacokinetics" 5th Annual Symposium Center for Protein Therapeutics (2013)
  • "Distribution of Etanercept to Sites of Inflammation in Collagen-Induced Arthritic Rats" 5th Annual Symposium Center for Protein Therapeutics, 323266818 (2013)
  • "Roles of FcgR in Pharmacokinetic Interactions of Immunosuppressants with mAb in Rheumatoid Arthritis" 5th Annual Symposium Center for Protein Therapeutics, 323266818 (2013)
  • "Pharmacokinetic-Pharmacodynamic Modeling" Genentech, Inc. (2013)
  • "CELL CYCLE MODELING OFFERS A PLATFORM TO OPTIMIZE COMBINATION OF CYTARABINE AND FLT3 INHIBITORS IN ACUTE MYELOID LEUKEMIA" Congress of the European Hematology Association, 18th Congress of the European Hematology Association (2013)
  • "Evolution of Mechanistic PK/PD Modeling - Our Future?" ASCPT 2013 Annual Meeting, ASCPT (2013)
  • "PHARMACODYNAMIC MODELING OF CELL CYCLE EFFECTS OF CYTARABINE AND FLT3 INHIBITORS ON ACUTE MYELOID LEUKEMIA CELLS" ASCPT 2013 Annual Meeting, ASCPT (2013)
  • "Applications of Minimal Physiologically-Based Pharmacokinetic Models" Research Institute of Pharmaceutical Sciences, Seoul National University (SNU) (2012)
  • "Moving PK/PD from Basic Towards Systems Pharmacology" 2012 International Conference of the Korean Society of Pharmaceutical Sciences and Technology (KSPST), KSPST (2012)
  • "Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics: Lessons From Corticosteroids" The Catholic University of Korea School of Medicine, Korean Society of Clinical Pharmacology and Therapeutics (2012)
  • "Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics: Lessons From Corticosteroids" Biomedical Research Institute, Chonnam National University Hospital (CNHU) (2012)
  • "Application of Minimal Physiologically-based Pharmacokinetic Models" 2012 AAPS Annual Meeting and Exposition, AAPS (2012)
  • "Mechanism-based Population Pharmacokinetic and Pharmacodynamic Modeling of Intravenous and Intranasal Dexmedetomidine" 2012 AAPS Annual Meeting and Exposition, AAPS (2012)
  • "Modeling Effects of Dexamethasone on Disease Progression of Bone Mineral Density in Collagen-induced Arthritic Rats" 2012 AAPS Annual Meeting and Exposition, AAPS (2012)
  • "Population Pharmacokinetics Analysis of Orally Administrated Baclofen in Pediatric Patients with Cerebral Palsy" 2012 AAPS Annual Meeting and Exposition, AAPS (2012)
  • "Proteome-level Pharmacokinetic/Pharmacodynamic Analysis of Corticosteroid-responsive Proteins in Rat Liver" 2012 AAPS Annual Meeting and Exposition, AAPS (2012)
  • "Extensive, proteome-level investigation of the corticosteroid pharmacodynamics with 12 time points using a reproducible and comprehensive ion-current-based profiling strategy" HUPO 2012 11th Annual World Congress, HUPO (2012)
  • "Moving PK/PD from Basic towards Systems Pharmacology" 2012 American College of Clinical Pharmacology (ACCP) Annual Meeting, American College of Clinical Pharmacology (2012)
  • "Pharmacokinetics/Pharmacodynamics/Pharmacogenomics: Lessons from Corticosteroids" 2012 American College of Clinical Pharmacology (ACCP) Annual Meeting, American College of Clinical Pharmacology (2012)
  • "Prednisone Dose and Exposure in Chronic Renal Transplant Recipients: One Size Does NOT Fit All" American Transplant Congress, American Transplant Congress (2012)
  • "Take it With Breakfast: But Does Food Reduce Prednisone Exposure As Much As It Reduces CNI Exposure in Renal Transplant Patients?" American Transplant Congress, American Transplant Congress (2012)
  • "Effects of sonic hedgehog inhibitor combined with nanoparticulate drug delivery on vascular permeability and efficacy in a pancreatic cancer model." Annual Meeting of the American Association for Cancer Research, American Association for Cancer Research (2012)
  • "Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine" 4th Annual UB Postdoc Research Symposium, University at Buffalo (2012)
  • "Multi-scale assessment of Everolimus and Sorafenib Combination in Pancreatic Cancer" American Association for Cancer Research, AACR (2012)
  • "Pharmacokinetic/Pharmacodynamic Modeling of GLP-1 in Healthy Rats" 4th Annual UB Postdoc Research Symposium, University at Buffalo (2012)
  • "Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-Induced Inflammation in Rats" 4th Annual UB Postdoc Research Symposium, University at Buffalo (2012)
  • "PK/PD/Disease Modeling in Cancer Chemotherapy" Hoffman La Roche, Hoffman La Roche (2012)
  • "What We Do in Pharmaceutical Sciences" UB Biology Honors Program (2012)
  • "Moving PK/PD From Basic Towards Systems Pharmacology" Rosa & Co. Impact of Modeling & Simulation in Drug Development Webinar, Rosa & Co. LLC. (2011)
  • "Population PK and PD Analysis of Oral Baclofen in Pediatric Patients with Cerebral Palsy" Pediatric Neurology Cerebral Palsy Center, Pediatric Neurology Cerebral Palsy Center (2011)
  • "Mechanistic Modeling of Tissue-specific Effects of Corticosteroids and Circadian Rhythms on Phosphoenolpyruvate Carboxykinase Expression in Rat Liver and Adipose Tissue" 2011 AAPS Annual Meeting and Exposition, AAPS (2011)
  • "Modeling Diabetes Disease Progression and Salsalate Intervention in Goto-Kakizaski Rats" 2011 AAPS Annual Meeting and Exposition, AAPS (2011)
  • "Modeling Pharmacokinetics/Pharmacodynamics of Abatacept and Disease Progression in Collagen-induced Arthritic Rats - A Population Approach" 2011 AAPS Annual Meeting and Exposition, AAPS (2011)
  • "Population Pharmacokinetic-Pharmacodynamic-Disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis" 2011 AAPS Annual Meeting and Exposition, AAPS (2011)
  • "Population Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Pancreatic Cancer Xenograft Mice" 2011 AAPS Annual Meeting and Exposition, AAPS (2011)
  • "Systems Pharmacological Analysis of Molecularly Targeted Agents in Pancreatic Cancer: Pharmacodynamic Design of Novel Therapeutic Trials" Clinical and Translational Research Colloquium, University at Buffalo (2011)
  • "The Relevance of Chronobiology in PK/PD" 2011 AAPS Annual Meeting and Exposition, AAPS (2011)
  • "Pharmacokinetic/Pharmacodynamic/Disease Progression Model of Anakinra, an Interleukin-1 Receptor Antagonist, in Collagen-Induced Arthritic Rats" Third Annual Symposium Center for Protein Therapeutics, University at Buffalo (2011)
  • "Pharmacokinetic/Pharmacodynamic/Disease Progression Model of Effects of Abatacept in Collagen-Induced Arthritic Rats" Third Annual Symposium Center for Protein Therapeutics, University at Buffalo (2011)
  • "Assessment of L-Cell Function Based on GLP-1 Response in an Oral Glucose Tolerance Test" 2011 PAGE Meeting, PAGE (2011)
  • "Modeling type 2 diabetes progression in newly diagnosed patients" Post-Doctoral Fellowship Day, University at Buffalo (2011)
  • "PK/PD Modeling of Drug Effects in Inflammation" Bristol Myers Squibb, Bristol Myers Squibb (2011)
  • "Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis" Post-Doctoral Fellowship Day, University at Buffalo (2011)
  • "Genome-wide analysis of circadian oscillations in gene expression in lung and its implications in lung homeostasis, repair and diseases" EXPERIMENTAL BIOLOGY 2011, APS (2011)
  • "Modeling Diabetes Progression in Goto-Kakizaki Rat and Salsalate Intervention" Pharmaceutical Sciences Poster Day, University at Buffalo (2011)
  • "Physiologically-Based Pharmacokinetics and Interactions of Everolimus and Sorafenib in Mice" American Association for Cancer Research, AACR (2011)
  • "Mechanism-Based PK/PD Model of Pramlintide in Patients with Type 1 Diabetes" AAPS Annual Meeting and Exposition, AAPS (2010)
  • "Modeling chemotherapeutic interactions of sorafenib and everolimus effects on pancreatic cancer cells" AAPS Annual Meeting and Exposition, AAPS (2010)
  • "Pharmacodynamic Interaction of Everolimus and Sorafenib Using In Vitro Whole Blood Lymphocyte Proliferation" AAPS Annual Meeting and Exposition, AAPS (2010)
  • "Pharmacokinetic - Pharmacodynamic - Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis" AAPS Annual Meeting and Exposition, AAPS (2010)
  • "Pharmacokinetic-Pharmacodynamic-Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis" AAPS Annual Meeting and Exposition, AAPS (2010)
  • "Pharmacokinetics and Pharmacodynamics of Rosiglitazone in Type 2 Diabetic Goto-Gakizaki (GK) Rats" AAPS Annual Meeting and Exposition, AAPS (2010)
  • "The Development of Mechanistic Population Pharmacokinetic Models to Support the Development of Targeted Release Characteristics from Modified Release Dosage Forms" AAPS Annual Meeting and Exposition, AAPS (2010)
  • "Department Highlights & Introduction and Historical Perspectives of PK/PD" 12th Buffalo Pharmaceutics Symposium, University at Buffalo (2010)
  • "Pharmacokinetic/Pharmacodynamic modeling of GLP-1 in healthy rats" 12th Buffalo Pharmaceutics Symposium, University at Buffalo (2010)
  • "PK/PD Modeling of Etanercept" Meeting of the Center for Protein Therapeutics (2010)
  • "Pediatric Pharmacokinetics: Lithium, Baclofen, and Hydroxyurea" 2010 Best Pharmaceuticals for Children Act Annual Meeting, National Institute of Child Health and Human Development & National Institutes of Health (2010)
  • "Pharmacokinetic - Pharmacodynamic - Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis" Annual Pharmaceutics Graduate Student Research Meeting (2010)
  • "Pharmacokinetics and Pharmacodynamics of Anti-CD3 Monoclonal Antibody, Otelixizumab in Subjects with Diabetes and Psoriasis" The Annual Meeting of the Population Approach Group in Europe, Population Approach Group in Europe (2010)
  • "Pharmacodynamic Interaction of Everolimus and Sorafenib Using In Vitro Whole Blood Lymphocyte Proliferation" Pharmacology Day 2010, University at Buffalo (2010)
  • "Target-Mediated Pharmacokinetic Modeling of Exendin-4 Disposition in Rats, Monkeys and Humans" Pharmacology Day 2010, University at Buffalo (2010)
  • "Various" Annual Course in PK/PD Modeling, University at Buffalo (2010)
  • "Research Perspectives of the UB Department of Pharmaceutical Sciences" SUNY Upstate Cancer Research Institute Workshop, SUNY Upstate Cancer Research Institute (2010)
  • "Systems Pharmacology of Anti-Inflammatory Effects of Corticosteroids" Mount Sinai School of Medicine Workshop, Mount Sinai School of Medicine (2010)
  • "PK/PD Modeling of Anti-Inflammatory Drug Effects" Drug Metabolism Department at Hoffman La Roche, Hoffman La Roche (2010)
  • "Assessing Drug Accumulation and Half-Lives During Multiple-Dosing Conditions" Annual Meeting of AAPS, AAPS (2009)
  • "Comparison of Liver and Muscle Genes for Presence of Circadian Rhythms" Annual Meeting of AAPS, AAPS (2009)
  • "Population Pharmacokinetic-Pharmacodynamic Model for the Triglyceride Lowering Effect of a PPAR Agonist: A Phase I Study" Annual Meeting of AAPS, AAPS (2009)
  • "Role of Sex (Gender) in Drug Kinetics and Dynamics" Frontier Science and Technology Research Foundation, Frontier Science and Technology Research Foundation (2009)
  • "Target-Mediated Pharmacokinetic Modeling of Exendin-4 Disposition in Rats, Monkeys and Humans" Annual Meeting of AAPS, AAPS (2009)
  • "Pharmacokinetic/Pharmacodynamic Modeling of Glucose Clamp Effects of Inhaled Insulin" American Conference on Pharmacometrics, ACoP (2009)
  • "Population PK/PD Modeling of the Effects of Vildagliptin on Active GLP-1, Glucose, and Insulin" American Conference on Pharmacometrics, ACoP (2009)
  • "Disease Progression Model in Type 2 Diabetic Rats" Pharmacology Day 2009 (2009)
  • "Disease Progression Model in Type 2 Diabetic Rats" Pharmacology Day 2009 (2009)
  • "Gene Expression as a Pharmacodynamic Marker" AAPS Workshop on Translational Biomarkers (2009)
  • "Mechanism-Based PK/PD Model of Pramlintide in Type 1 Diabetic Patients" Pharmacology Day 2009 (2009)
  • "Methods of Utilizing Baseline Values for Indirect Response Models" Pharmacology Day 2009 (2009)
  • "Model-Based Comparison of Binocrit and Erypo Pharmacokinetics after Repeated I.V. and S.C. Administration" WCN (World Congress of Nephrology) (2009)
  • "Role of Sex/Gender in Drug Kinetics and Dynamics" City-Wide Grand Rounds, Erie County Medical Center (2009)
  • "Systems pharmacology of anti-inflammatory effects of corticosteroids" Experimental Biology 2009 Meeting (2009)
  • "Animal Scaling of Pharmacokinetics and Pharmacodynamics" , Hoffman-LaRoche (2009)
  • "Pharmacokinetic and Pharmacodynamic Modeling of Anti-inflammatory Drugs" , Hoffman-LaRoche (2009)
  • "Disease Progression Model in Type 2 Diabetic Goto-Kakizaki Rats" American Association of Pharmaceutical Sciences Meeting (2008)
  • "Mechanism-Based Modeling of Leptin Production and Effect on Food Intake in Normal Wistar (CON) and Type 2 Diabetic Goto-Kakizki Rats (GK) on Different Diets" American Association of Pharmaceutical Sciences Meeting (2008)
  • "Mechanism-Based Pharmacokinetic Pharmacodynamic (PKPD) Model for the Inverse Inoculum Effect of Imipenem Against Psedomonas Aeruginosa" American Association of Pharmaceutical Sciences Meeting (2008)
  • "Modeling Sitagliptin Effects on Glucagon-Like Peptide 1 (GLP-1) and Glucose in Type 2 Diabetic Patients (T2DM)" American Association of Pharmaceutical Sciences Meeting (2008)
  • "Bioequivalence of Biosimilars - Is Pharmacodynamic Equivalence Sufficient?" Ehrlich II -2nd World Conference on Magic Bullets Celebrating the 100th Anniversary of the Nobel Prize Award to Paul Ehrlich (2008)
  • "Corticosteroids - Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenomics, and Disease Progression" Ehrlich II -2nd World Conference on Magic Bullets Celebrating the 100th Anniversary of the Nobel Prize Award to Paul Ehrlich (2008)
  • "First-Dose Pharmacokinetics of Lithium Carbonate in Children and Adolescents" Annual Meeting of the American Academy of Child and Adolescent Psychiatry, AACAP (2008)
  • "Pharmacokinetic Pharmacodynamic Concepts" Ehrlich II -2nd World Conference on Magic Bullets Celebrating the 100th Anniversary of the Nobel Prize Award to Paul Ehrlich (2008)
  • "Exposure-Response Modeling" Land O'Lakes Conference on Drug Metabolism/Applied Pharmacokinetics, University of Wisconsin (2008)
  • "Multiple-Pool Lifespan Models for Neutropenia to Assess the Population Pharmacodynamics of Unbound Paclitaxel from Two Formulations in Cancer Patients" Quantitative and Systems Pharmacology Workshop, National Institute of General Medical Sciences (2008)
  • "Population PK/PD Modeling of Inhibition of Dipeptidyl Peptidase IV" Quantitative and Systems Pharmacology Workshop, National Institute of General Medical Sciences (2008)
  • "Systems PK/PD/PG/DIS model for anti-inflammatory effects of corticosteroids" Quantitative and Systems Pharmacology Workshop, National Institute of General Medical Sciences (2008)
  • "Utility of PK/PD modeling in drug development & PK/PD modeling of anti-inflammatory drugs." Merial Pharmaceuticals, Merial Pharmaceuticals (2008)
  • "Erythropoietin Receptor-Mediated Disposition and Dynamic Model for Human Recombinant Erythropoietin (rHuEPO)" AAPS Annual Meeting (2007)
  • "Characterization and application of a new model for the assessment of non-competitive drug-drug interactions" AAPS Annual Meeting (2006)
  • "Development of mathematical model for chemotherapy-induced anemia in rats and its application to selection of rHuEPO dosing strategy" AAPS Annual Meeting (2006)
  • "Population pharmacokinetic and pharmacodynamic modeling of a novel erythropoietin receptor agonist, HematideTM, in healthy volunteers" , AAPS Annual Meeting (2006)
See all (133 more)
Service Activities:
  • University of Buffalo, Search Committee for Dean, School of Pharmacy; Committee Member (2013)
  • E Fund Proposal Review Committee; Committee Member (2012)
  • Advisory Committee, Center for Clinical and Translational Research Grant Application; Committee Member (2012–2015)
  • Pilot Studies Oversight Review Committee; Committee Member (2012)
  • Committee; AAPS/AACP NIH Research Task Force; Committee Member (2011)
  • VPR External Advisory Committee; Medical College of Wisconsin; Committee Member (2011–2014)
  • External Reviewer, Promotion; Rutgers University, New Jersey; External Reviewer (2011)
  • External Reviewer, Promotion; Eschelman School of Pharmacy, University of North Carolina; External Reviewer (2011)
  • NIDDK - National Institute of Diabetes and Kidney Diseases Special Emphasis Panel; NIDDK - Grant Applicatins; Panel Member (2011)
  • Program Project: Mechanisms of Drug Disposition During Pregnancy; NIH - Program Project Grant Applications: Mechanisms of Drug Disposition During Pregnancy; Panel Member (2011)
  • RFA Panel: Developmental Pharmacology; NIH - RFA Panel: Developmental Pharmacology; Panel Member (2011)
  • Special Review Committee for Glue Grants; NIH Served as chair for NIH Special Review Committee for Glue Grants, March 25, 2011; Reviewer (2011)
  • School of Pharmacy and Pharmaceutical Sciences Accreditation Review Committee - Organization and Management; Committee Member (2010)
  • Reviewer; NIH Director‘s Opportunity 5 Themes General Basic Science; Reviewer (2010)
  • NIH Committee Meeting - Bethesda, MD; Quantitative and Systems Pharmacology; Committee Member (2010)
  • Special Emphasis Panel; NIGMS; Panel Member (2009)
  • Reviewer; National Institute of Diabetes and Digestive and Kidney Diseases; Reviewer (2009)
  • International Scientifica Advisory Board; 6th International Symposium on Measurement and Kinetics of In Vivo Drug Effects, The Netherlands; Advisory Board (2009)
  • Planning Committee; Translational Biomarkers for Accelerating Drug Development: From Preclinical to Clinical; Committee Member (2009)
  • Special Emphasis Panel; NIGMS; Panel Member (2009)
  • SUNY Distinguished Service Review Committee; Committee Member (2008)
  • Organizing Committee; AAPS Workshop on Biomarkers and Drug Development; Committee Member (2008)
  • MRBS Faculty Committee; Committee Member (2007)
  • Organizing Committee; Workshop on Pharmacology and Systems Biology; Committee Member (2007)
  • Selection Committee; Volwiler Award, Am Assn Coll Pharmacy; Committee Member (2006–2008)
  • School of Pharmacy Awards Committee; Committee Member (2005)
  • Executive Committee; Committee Member (2001–2016)
  • School Promotions and Tenure Committee; Committee Member (2001–2016)

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Contact Information

404 Kapoor Hall
Buffalo, NY 14214-8033
Phone: (716) 645-2855
Fax: 7168296569
Email: wjjusko@buffalo.edu


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