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Marilyn                        Morris

Marilyn E. Morris PhD

Department of Pharmaceutical Sciences

SUNY Distinguished Professor and Chair

 
Professional Summary:

Research interests are focused in the area of drug transporters and their role in the pharmacokinetics/pharmacodynamics (PK/PD) of drugs. Studies also focus on drug transporters as therapeutic targets. Current research projects:

1. Gamma-hydroxybutyric acid (GHB) Toxicokinetics and Toxicodynamics. GHB is a drug of abuse, known as a "club drug". We are characterizing the mechanisms underlying the toxicokinetics and toxicodynamics of GHB, and evaluating methods to treat overdoses of GHB. For these studies, we are characterizing transport of GHB by Monocarboxylic Acid Transporters (MCTs), transport proteins that determine the absorption, renal clearance, and distribution of GHB throughout the body, including its distribution to the brain, the site of action. Our goal is to devise treatment strategies to treat overdoses of GHB, in order to save lives.

2. Membrane Transporters in Breast Cancer. Drug resistance is the main cause for therapeutic failure and death in breast cancer. My laboratory is interested in the discovery of new classes of compounds useful in reversing multidrug resistance (MDR) to cancer chemotherapeutic agents. One of the main causes of MDR in cancers is due to the overexpression of the efflux transport proteins, P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Our current studies are evaluating various dietary components, organic isothiocyanates and flavonoids, for their effects on BCRP-mediated transport and on the efficacy and toxicity of chemotherapeutic agents.
We are currently examining a new drug target in breast cancer, monocarboxylate transporters.


Education and Training:
  • Postdoctoral Fellowship, University of Toronto (1985)
  • PhD, State University of New York at Buffalo (1984)
  • MS, University of Ottawa (1976)
  • Pharmacy Residency Program, Ottawa General Hospital (1974)
  • BS, University of Manitoba (1973)
Employment:
  • Professor and Chair (2017-present)
  • Professor, University at Buffalo, SUNY, University at Buffalo, SUNY (2001-present)
  • SUNY Distinguished Professor
  • Vice Chair of Specialist Practice, Pharmaceutical Sciences, University at Buffalo, SUNY (2014–2016)
  • Associate Dean, The Graduate School, University at Buffalo, SUNY (2006–2012)
  • Associate Professor, Pharmaceutical Sciences, University at Buffalo, SUNY (1991–2001)
  • Assistant Professor, Pharmaceuitcal Sciences, University at Buffalo, SUNY (1985–1991)
  • Lecturer/ Assistant Professor (Pharmacy), Dalhousie University, Dalhousie University, Canada (1976–1978)
  • Clinical pharmacist, Pharmacy, Children's Hospital of Eastern Ontario, Canada (1975–1976)
Awards and Honors:
  • AAPS Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolsim (2016)
  • SUNY Distinguished Professor (2016)
  • Innovation in Biotechnology Award, National Biotechnology Conference (2015)
  • UB Distinguished Professor, University at Buffalo (2014)
  • Alumni of Distinction Award, Faculty of Pharmacy, University of Manitoba (2013)
  • Elected Fellow, American Association for the Advancement of Science (2013)
  • UB Distinguished Postdoctoral Mentor Award (2012)
  • Service Award, from the Pharmacokinetics, Pharmacodynamics and Drug Metabolism Section (2010)
  • Pharmacy Leadership Society Faculty Service Award, Beta Omicron Chapter, University at Buffalo (2010)
  • Nomination for Teacher of the Year (2009)
  • Chancellor's Award for Excellence in Scholarship and Creative Activities (2006)
  • Faculty in Leadership (2005)
  • Francis Dudley Meyer Award for Breast Cancer Research (2005)
  • Elected Fellow, American Association of Pharmaceutical Scientists (2003)
  • National Science Foundation POWRE Award (1999)
  • National Science Foundation Career Development Award (1996)
  • Dr. Nuala McGann Drescher Award (1990)
  • Merck Faculty Development Award (1986)
  • Medical Research Council of Canada Fellowship (1984)
  • Buffalo Pharmaceutics Graduate Scholar (1983)
  • Presidential Graduate School Fellowship (1978)
  • Medical Research Council of Canada Studentship (1975)
  • Medical Research Council of Canada Studentship (1974)
  • Canadian Foundation for the Advancement of Pharmacy Scholarship (1974)
  • University Gold Medal in Pharmacy (1973)
  • Manitoba Pharmaceutical Association Silver Medal (1973)
  • Centennial Scholar (1972)

Research Expertise:
  • Membrane Transport: The role of drug transporters in pharmacokinetics and pharmacodynamics. Membrane transporters as therapeutic targets
  • Pharmacokinetics/Pharmacodynamics
Grants and Sponsored Research:
  • February 2016–January 2018
    PhRMA Graduate Fellowship
    Pharmaceutical Manufacturers Assoc.
    Role: Principal Investigator
    $40,000
  • September 2012–July 2017
    Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies
    NIDA
    Role: Principal Investigator
  • July 2015–June 2017
    Diversity Supplement: Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies
    NIDA
    Role: Principal Investigator
    $44,000
  • January 2016–January 2017
    Monocarboxylate Transporters in GHB Disposition
    Jazz Pharmaceuticals, Inc.
    Role: Principal Investigator
  • March 2012–December 2016
    IMSD: Initiative for Maximizing Student Development: Enabling Access to Cutting-Edge Biomedical and Behavioral Research
    NIH/NIGMS
    Role: Co-Investigator
  • September 2015–August 2016
    Role of FcRn, megalin and cubilin in the renal clearance and catabolism of IgG in diabetes mellitus/diabetic nephropathy
    UB Center for Protein Therapeutics (Balthasar)
    Role: Principal Investigator
  • September 2015–August 2016
    Megalin/Cubilin in the Renal Processing of Peptides and Proteins
    UB Center for Protein Therapeutics (Balthasar)
    Role: Principal Investigator
  • September 2014–August 2016
    Evaluation of mAb Brain Disposition in Alzheimer’s Disease
    Center for Protein Therapeutics
    Role: Principal Investigator
  • June 2013–June 2016
    iSEED Institute of Strategic Enhancement of Educational Diversity
    University at Buffalo
    Role: Contributor
  • September 2014–August 2015
    Effect of Type II Diabetes Mellitus and Chronic Kidney Disease on Antibody Pharmacokinetics and Subcutaneous Bioavailability
    Center for Protein Therapeutics
    Role: Principal Investigator
Patents:
  • High Throughput Spectrofluormetric Screen for Drug Binding to Human Serum P Type: Regular (2001)

Journal Articles:
See all (150 more)
Abstracts:
  • Jaenecke K; Stewart M; Morris ME; Brazeau DA; Havard PF. A Semi-Quantitative Comparison of P-glycoprotein Protein Expression in Peripheral Blood Mononuclear Cells Between the Maternal and Fetal Compartments. Accepted to the 2009 APhA Annual Meeting, San Antonio TX, April 3rd - 6th, 2009.. 2009 APhA Annual Meeting, San Antonio TX, April 3rd - 6th, 2009.. 2009.
Books and Book Chapters:
  • You G. Drug Transporters: Molecular Characterization and Effects on Drug Disposition. Second edition.. 2014.
  • Wang X Morris ME. Diet/nutrient Interactions with Drug Transporters. 2014.
  • Felmlee MA; Morris ME; Mager DE. Mechanism-based pharmacodynamic modeling. Computational Toxicology. 2012; 1.
  • Morris ME. Membrane Drug Transporters. Foy's Priciples of Medicinal Chemistry. 2012.
  • An G; Morris ME. Herbal Supplement-based Interactions. Enzymatic- and Transporter-Based Drug Drug Interactions: Progress and Future Challenges. 2009.
  • You G; Morris ME. Overview of Drug Transporter Families. Drug Transporters: Molecular Characterization and Effects on Drug Disposition. 2007.

Professional Memberships:
  • American Assoc for the Advancement of Science (2012)
  • International Society for the Study of Xenobiotics (1990)
  • Society for Experimental Biology and Medicine (1987)
  • American Association of Colleges of Pharmacy (1987)
  • American Society for Pharmacology and Experimental Therapeutics (1987)
  • American Association of Pharmaceutical Scientists; Chair of PPDM section (1986)
  • American Society for Pharmacology and Experimental Therapeutics
  • American Association of Pharmaceutical Scientists (AAPS)
  • United University Professions
  • American Association of Colleges of Pharmacy (AACP)
  • International Society for the Study of Xenobiotics
  • American Association for the Advancement of Science
  • International Pharmaceutical Federation
See all (3 more)
Presentations:
  • "In vivo development and metabolomics investigation of the role of monocarboxylate transporter 6 (MCT6)" AAPS National Biotechnology Conference, American Association of Pharmaceutical Scientists (2017)
  • "Organic anion uptake of GHB at the BBB: incorporation of brain transport in modeling of PK/PD" World Congress in the Pharmaceutical Sciences, International Federation of Pharmacy, Board of Pharmaceutical Sciences, FIP (2017)
  • "Plenary Closing Debate, , Stockholm Sweden May 24, 2017" World Congress in the Pharmaceutical Sciences, International Federation of Pharmacy, Board of Pharmaceutical Sciences, (2017)
  • "Characterizing the expression of the renal reabsorption proteins megalin and cubilin through the progression of Type 2 diabetes" Experimental Biology Annual Meeting, Experimental Biology (2017)
  • "Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration." Copenhagen Workshop on Injectables –Current and future challenges, University of Copenhagen, International (2017)
  • "Monocarboxylaye transporter family: Role in drug disposition and disease" Seminar, University at Buffalo, Department of Pharmaceutical Sciences (2016)
  • "Work-Life Balance" Presentation to UB Pharmacy Practice Faculty, School of Pharmacy and Pharmaceutical Sciences, Dept of Pharmacy Practice (2016)
  • "Pharmaceutical Industry-Academic Research Support and Collaborations: What are the Opportunities?" AAPS Annual Meeting, American Association of Pharmaceutical Scientists, Professional Development Program (2015)
  • "Transport Your Renal Clearance: Modeling Approaches to Describe Renal Drug Transport." AAPS Annual Meeting, American Association of Pharmaceutical Scientists, Sunrise Session (2015)
  • "Predicting Clinical Parameters: Transporters" Seventeenth Annual Land O’ Lakes Conference on Drug Metabolism/Applied Pharmacokinetics, Factors Influencing the Future of Drug Metabolism and Pharmacokinetics,, Land O’ Lakes Conference, Drug Metabolism/Applied Pharmacokinetics (2015)
  • "The Art of Modeling" Seventeenth Annual Land O’ Lakes Conference on Drug Metabolism/Applied Pharmacokinetics Short Course, Land O'Lakes Conference, Drug Metabolism/Applied Pharmacokinetics (2015)
  • "Why membership in a professional organization is important for your career" American Association of Bangladeshi Pharmaceutical Scientists Convention, American Association of Bangladeshi Pharmaceutical Scientists, Keynote speech (2015)
  • "Effect of Type II Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability" AAPS National Biotechnology Conference, American Association of Pharmaceutical Scientists, National Biotechnology Conference (2015)
  • "Effect of Type II Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability" AAPS National Biotechnology Conference- Graduate Student Award, AAPS, National Biotechnology Conference (2015)
  • "Finding mentors and supporters – “the how and who" National Biotechnology Conference, AAPS, symposium on Women In Pharmaceutical Sciences – Career Development: Facts, Myths, and Tips (2015)
  • "A Novel Mechanistic and Physiologically-Based Population Pharmacokinetic Model Incorporating Monocarboxylate Transporter 1 (MCT1)-Mediated Brain Uptake of γ-hydroxybutyric acid (GHB)." AAPS/International Transporter Consortium Drug (ITC) Transporter in ADME Workshop, American Association of Pharmaceutical Scientists, AAPS Drug Transporter Focus Group/International Drug Transporter Consortium (2015)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" invited seminar speaker, University of Michigan, University of Michigan, School of Pharmacy (2015)
  • "Monocarboxylate Transporters (MCT) Expression and Function in Triple Negative Breast Cancer (TNBC) Cell Lines: Potential Cancer Target" AAPS/International Transporter Consortium (ITC) Drug Transporter in ADME Workshop, American Association of Pharmaceutical Scientists, Drug Transporter Focus Group and International Drug Transporter Consortium (2015)
  • "Novel Mechanistic Kidney Model Incorporating Physiological Fluid Reabsorption and Transporter-Mediated Renal Reabsorption: A Population Pharmacokinetics Approach." AAPS/International Transporter Consortium (ITC) Drug Transporter in ADME Workshop, American Association of Pharmaceutical Scientists, AAPS Drug Transporter Focus Group and International Transporter Consortium (2015)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Invited seminar speaker, Purdue University, Purdue University, School of Pharmacy (2015)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Invted seminar speaker, University of Indiana, University of Indiana, Clinical Pharmacology department (2015)
  • "A Quantitative Structure-Pharmacokinetic Relationship (QSPKR) Approach for the Prediction of Renal Clearance in Humans." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2014)
  • "Age and Gender-dependent Expression of Monocarboxylate Transporters" AAPS Annual Meeting, AAPS (2014)
  • "Gamma-hydroxybutyric Acid Toxicokinetics are Gender and Species-Dependent" AAPS Annual Meeting, AAPS (2014)
  • "MCT1 Expression and Function in the Murine Breast Cancer 4T1 Cell Line: A Potential Cancer Target." AAPS Annual Meeting, AAPS (2014)
  • "The LPLS Classification System: Practical and parsimonious decision–rules to guide drug discovery and development of new molecular entities." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2014)
  • "Women In Pharmaceutical Sciences – Career Development: Facts, Myths, and Tips" AAPS annual meeting, American Association of Pharmaceutical Scientists (2014)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Sixth annual Pittsburgh’s student chapters research symposium., University at Pittsburgh (2014)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters." Invited speaker, Mercer University, Mercer University, School of Pharmacy (2014)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters." invited speaker University of Toronto, University of Toronto, School of Pharmacy (2014)
  • "Graduate Education in the Pharmaceutical Sciences: The Path Forward" Chinese Pharmaceutical Association Annual Meeting, Chinese Pharmaceutical Association (2014)
  • "Graduate Education in the Pharmaceutical Sciences: The Path Forward" Sino-American Pharmaceutical Association- Greater Philadelphia, Sino-American Pharmaceutical Association- Greater Philadelphia (2014)
  • "Why membership in a professional organization is important to your career." AAPS Student Chapter, Mercer University, Mercer University (2014)
  • "Effect of Type II Diabetes Mellitus and Chronic Kidney Disease on Antibody Pharmacokinetics and Subcutaneous Bioavailability." Center for Protein Therapeutics Annual Symposium,, Center for Protein Therapeutics (2014)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" invited speaker, University of Sydney, Sydney Australia, University of Sydney, School of Pharmacy (2014)
  • "Why membership in a professional organization is important to your career" Pharmaceutical Sciences World Congress, Student Meeting, Monash University, Melbourne Australia, Pharmaceutical Sciences World Congress, Federation Pharmaceutical Federation (2014)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" invited speaker, University of New England, University of New England, School of Pharmacy (2014)
  • "Sim CYP Workshop" Workshop, SimCyp Inc, Certera (2014)
  • "Monocarboxylate transporter inhibition: a potential treatment strategy for γ-hydroxybutyric acid and ketamine overdose" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2013)
  • "Effect of Type II Diabetes Mellitus on Antibody Pharmacokinetics and Subcutaneous Bioavailability." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2013)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" 2013 Alumni Distinguished Speaker Symposium, School of Pharmacy, University of Manitoba, University of Manitoba, School of Pharmacy (2013)
  • "Effect of type II diabetes and chronic kidney disease on antibody pharmacokinetics and subcutaneous bioavailability" Center for Protein Therapeutics Annual Symposium,, Center for Protein Therapeutics (2013)
  • "Evaluation of microdialysis to detect proteins in brain extracellular fluid," Center for Protein Therapeutics Annual Symposium, Center for Protein Therapeutics (2013)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Key note speaker, AAPS@China Meeting, Chinese University of Hong Kong, Hong Kong, Chinese University of Hong Kong (2013)
  • "Membrane Transporters in Drug Pharmacokinetics/Pharmacodynamics," CLIMB-UP/iSEED Seminar, University at Buffalo, University at Buffalo (2013)
  • "Gamma-hydroxybutyrate Toxicokinetics and Toxicodynamics: Effect of Monocarboxylate Transporters" Great Lakes Drug Metabolism Conference May 9-10, 2013, Great Lakes Drug Metabolism Group (2013)
  • "Gamma-hydroxybutyrate: Toxicokinetics and Toxicodynamics and Treatment Strategies" Molecular Recognition in Biological Systems and Bioinformatics Symposium., University at Buffalo (2013)
  • ". A novel monocarboxylate transporter inhibitor as a potential treatment strategy for ?-hydroxybutyric acid overdose" AAPS Transporter Workshop, AAPS (2013)
  • ". Generation and Purification of Recombinant Human OAT1 and OAT3 Fusion Proteins." AAPS Transporter Workshop, AAPS (2013)
  • "Transporter-Mediated Drig-Food Interactions:Effect of Flavonoids" First International Conference on Pharma and Food (2012)
  • "Dietary Flavonoid Fisetin is a Substrate and Inhibitor of Human Organic Anion Transporter 1 (OAT1)." AAPS Annual Meeting, AAPS (2012)
  • "Effect of Monocarboxylate Transporter (MCT) Inhibition on the Oral Toxicokinetics/Toxicodynamics of ?-hydroxybutyrate (GHB) and ?-butyrolactone (GBL)." AAPS Annual Meeting, AAPS (2012)
  • "Effects of L-lactate and D-mannitol on GHB toxicokinetics/toxicodynamics." AAPS Annual Meeting 2012, AAPS (2012)
  • "Intestinal Transporters: Bioavailability, Interactions and Drug Delivery" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2012)
  • "Introduction to Metabolites and Metabolite kinetics" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2012)
  • "Monocarboxylate Transporters in Health and Disease: MCTs as therapeutic targets." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2012)
  • "Postdoc After Graduate School" National Biotechnology Conference, American Association of Pharmaceutical Scientists (2012)
  • "Postdoc: Is this for you?" AAPS Annual Meeting, AAPS (2011)
  • "Club drug interactions: Effects of MDMA and ketamine on gamma-hydroxybutyrate PK/PD" AAPS Annual Meeting, AAPS (2011)
  • "Gamma-hydroxybutyric acid is a substrate for monocarboxylate transporters in rat blood-brain barrier cells" AAPS Annual Meeting, AAPS (2011)
  • "Lymphatic uptake of near infrared dye labeled BSA: Pharmacokinetics and biodistribution studies in SKH-1 mouse model" AAPS Annual Meeting, AAPS (2011)
  • "Monocarboxylate Transporter Inhibition with L-lactate Increases the Renal Clearance of ?-Hydroxybutyrate in Humans" AAPS Annual Meeting, AAPS (2011)
  • "Respiratory Depression in ?-hydroxybuytate Overdose: Interaction with ethanol and treatment using monocarboxylate transporter inhibition" AAPS Annual meeting, AAPS (2011)
  • "Lymphatic uptake of proteins after SC administration in rodents: In vivo fluorescence and PET as imaging tools" National Biotechnology Conference, American Association of Pharmaceutical Scientists (2011)
  • "Effects of Ethanol and treatment with L-lactate on GHB-induced respiratory depression." Sigma Xi Graduate Research Conference (2011)
  • "Pharmacokinetics and pharmacodynamics of Gamma-hydroxybutyrate" Seminar Program, Department of Pharmacology and Toxicology (2011)
  • "A mechanistic pharmacokinetic model for the drug of abuse ?-hydroxybutyrate (GHB) in rats." American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientists (2010)
  • "Biliary excretion in animals and humans:Re-evaluation of a molecular weight threshold" American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientistd (2010)
  • "Determination of mitoxantrone in mouse plasma and tissues by an improved HPLC assay and its application in a pharmacokinetic study." AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2010)
  • "Interspecies prediction of human biliary clearance based on studies in rats of multiple animal species." American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientists (2010)
  • "Physiological based pharmacokinetic model for vascular endothelial growth factor C156S (VEGF C156S) in mice" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2010)
  • "Transport and efflux of quercetin and biochanin A in MDCK cell monolayers-Role of efflux transporters" American Association of Pharmaceutical Scientists Annual Meeting, American Association of Pharmaceutical Scientists (2010)
  • "Effects of naturally-occurring breast cancer preventive agents on the metabolism of estradiol in the estrogen-responsive human breast cancer cell line MCF-7" AAPS Annual Meeting, American Association of Pharmaceutical Scientists (2010)
  • "Transporter-mediated drug-herb and drug-food interactions, Symposium on Problems and Strategies in Herb/Food-Drug Interactions" American Chemical Society Annual Meeting, American Chemical Society (2010)
  • "Gamma-hydroxybutyratic acid, A drug of abuse, exhibits tissue specific distribution kinetics." Pharmacology Day, University at Buffalo (2010)
  • "Non-invasive real time quantitative imaging of lymphatic uptake of subcutaneously administered albumin in mice" National Biotechnology Conference, American Association of Pharmaceutical Scientists (2010)
  • "The bioflavonoid kaempferol inhibits ABCG2-mediated quercetin efflux through competitive inhibition." Pharmacology Day, University at Buffalo (2010)
  • "The pharmacokinetics and lymphatic exposure of recombinant human vascular endothelial growth factor VEGF-C156S after iv and sc administration" Pharmacology Day, University at Buffalo (2010)
  • "Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies" Seminar Program for Institute on Environmental Health and Science, Institute on Environmental Health and Science, Wayne State University (2010)
  • "Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB" North Jersey Drug Metabolism Discussion Group Spring Meeting, American Chemical Society (2010)
  • "The bioflavonoid kaempferol inhibits ABCG2-mediated quercetin efflux through competitive inhibition." Academic Celebration of Excellence, University at Buffalo (2010)
  • "Intestinal transporters: bioavailability, interactions and drug delivery" International Society for the Study of Xenobiotics (ISSX) Annual Meeting. Short Course on Transporters in Drug Disposition and Elimination, ISSX (2009)
  • ". Development of physiological based pharmacokinetic model to predict tissue distribution of Vascular Endothelial Growth Factor C156S" American College of Clinical Pharmacology annual meeting, American College of Clinical Pharmacology (2009)
  • "A Mechanistic Clinical Pharmacokinetic Model for Stains Which Are OATP1B1 Substrates and Prediction of Their Drug Interactions with Gemfibrozil" UB-Pfizer Conference (2009)
  • "A Mechanistic Pharmacokinetic Model for the Drug of Abuse" UB-Pfizer Conference (2009)
  • "Development of physiological based pharmacokinetic model to predict tissue distribution of Vascular Endothelial Growth Factor C156S" UB-Pfizer Conference (2009)
  • "Inhibition of monocarboxylate transporters as a potential treatment strategy for ?-hydroxybutyric acid overdose." Pharmacology Day (2009)
  • "Toxicokinetics and Toxicodynamics of the drug of abuse gamma-hydroxybutyrate." , University of Georgia (2009)
  • "Transport and efflux of quercetin and biochanin A in MDCK cell monolayers -- role of efflux transporters" Pharmacology Day, University at Buffalo (2009)
  • "A Semi-Quantitative Comparison of P-glycoprotein Protein Expression in Peripheral Blood Mononuclear Cells Between the Maternal and Fetal Compartments." 2009 APhA Annual Meeting, APhA Annual Meeting (2009)
  • "Characterization of sodium dependent monocarboxylate transporter-1 (SMCT1)-mediated GHB transport in FRTL-5 cells" Experimental Biology annual meeting, Federation of Experimental Biology/American Assoc of Pharmacology and Experimental Therapeutics (2009)
  • "Monocarboxylate transporter (MCT)-mediated transport of ?-hydroxybutyric acid in human intestinal Caco-2 cells" Experimental Biology Annual Meeting, American Assoc of Pharmacology and Experimental Therapeutics (2009)
  • "Non-invasive real time quantitative imaging of lymphatic uptake of subcutaneously administered proteins in mice" Postdoc Research Symposium, Graduate School, University at Buffalo (2009)
  • "The Effect of Flavonoids on Transport of Mitoxantrone in ABCG2" Celebration of Excellence, UB (2009)
  • "Establishment of an Office of Postdoctoral Scholars at the University at Buffalo, SUNY: Successes and Challenges." National Postdoctoral Association (2009)
  • "Postdoc Survival Workshop: Teaching Responsible Conduct of Research" National Postdoctoral Association (2009)
  • "A Mechanistic Clinical PK Model for the OATP-mediated Pravastatin and Gemfibrozil Drug Interaction" American Association of Phsrmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
  • "Effect of Dietary Phenethyl Isothiocyanate on Tumor Growth in an Animal Model of Estrogen-dependent Breast Cancer" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
  • "Effect of multiple flavonoids combinations on breast cancer resistance protein (ABCG2)-mediated transport" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
  • "Inhibition of the BCRP-mediated transport of mitoxantrone by the flavonoids kaempferide and biochanin A" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
  • "Pharmacokinetic and pharmacodynamic interactions of dietary flavonoids" American Association of Pharmaceutical Scientists Annual Meeting, AAPS (2008)
  • "Quantitative structure-activity relationships for the ABCG2-mediated transport of flavonoids" American Association of Pharmaceutical Scientists (AAPS) annual meeting, AAPS (2008)
  • "A career in the pharmaceutical sciences: Unlimited potential" Student Research and Career Day, Departments of Pharmacology and Pharmaceutical Sciences, University of Cincinnati (2008)
  • "Dietary flavonoids: Effects on xenobiotic and carcinogen membrane transport and disposition" World Congress of Pharmacy and Pharmaceutical Sciences, FIP Congress (2008)
  • "The role of drug transport in accelerating drug discovery/development" Drug Development (MS degree) program, University of Cincinnati (2008)
  • "Development and pharmacokinetic evaluation of liposomal VEGF-C156S." Great Lakes Symposium (2008)
  • "Formulation and biophysical characterization of liposomes encapsulating VEGF C156S for pharmacokinetic (PK) and pharmacokinetic (PD) studies" National Biotechnology Conference, AAPS (2008)
  • "Formulation and biophysical characterization of liposomes encapsulating VEGF-C156S for PK/PD studies." Sigma Xi Research Conference (2008)
  • "Formulation and biophysical characterization of liposomes encapsulating VEGF-C156S for PK/PD studies." UB-Pfiszer Conference (2008)
  • "Enhancement of mitoxantrone cytotoxicity and transport by flavonoids Biochanin A and Kaempferide, two potent BCRP inhibitors" Sigma Xi research Symposium (2008)
  • "Prediction of Biliary Excretion in Rats and Humans Using Quantitative Structure- Pharmacokinetic Relationships." , Pfizer Global Inc. (2008)
See all (101 more)
Service Activities:
  • Dean's Committee on Addictions; Member (2016–2017)
  • Searle Grant proposal review for UB; Ad Hoc Reviewer (2016)
  • Program Review for School of Pharmacy, Washington State University; Ad Hoc Reviewer (2016)
  • APhA Remington Award Review; Ad Hoc Reviewer (2016)
  • UB Mentoring Committee; University at Buffalo; Member (2015–present)
  • Defense Threat Reduction Agency; grant reviews and progress evaluation; Grant Reviewer (2015)
  • National Institute of Child Health and Human Development; NIH contract reviews; Grant Reviewer (2015)
  • UB Awards Development Committee; University at Buffalo; Member (2015–present)
  • AAPS Awards Review Committee; Grant Reviewer (2015)
  • UB Awards Committee; University at Buffalo; Member (2015–present)
  • University Deans Advisory Committee; University at Buffalo; Department Representative (2015–present)
  • SPPS Teacher of the Year Selection Committee; Department Representative (2014–2016)
  • PHC Graduate Awards Committee; Member (2014–present)
  • Elected Executive Committee Member, Board of Pharmaceutical Sciences, International Pharmaceutical Federation; Service to the Profession-International; Executive Board (2014–2018)
  • AAPS Nominations Committee; Chair-Elect (2014–2015)
  • AAPS Past President; Past President (2014–2015)
  • Board of Pharmaceutical Sciences, FIP; Executive Board (2014–2018)
  • AAPS Research Funding and Resources Committee; American Association of Pharmaceutical Scientists; Member (2014–present)
  • Member, Graduate Education committee, American Association of Colleges of Pharmacy; Committee Member (2014–present)
  • Defense Threat Reduction Agency grant reviews; Grant Reviewer (2014)
  • School of Pharmacy Executive Committee; Member (2014–present)
  • Strategic Planning Committee; Chair of Services Subcommittee; Chair (2014)
  • AAPS President; elected president of the American Association of Pharmaceutical Scientists; President (2013–2014)
  • AAPS Foundation; Executive Board (2013–present)
  • Maine Sea Grant Program Reviewer; Grant Reviewer (2013)
  • Edward Mallinckrodt Foundation Review Committee, Office of the VP Research, UB; Grant Reviewer (2013)
  • NIH Study Section (XNDA) grant reviewer; National Institutes of Health Review submitted NIH grants; Grant Reviewer (2013)
  • Advisory Committee member, iSEED program, UB; Executive Board (2013–present)
  • Molecular Pharmaceutics Editorial Board; Editorial Board Member (2013–present)
  • AAPS President-Elect; American Association of Pharmaceutical Scientists; Executive Board (2012–2013)
  • Chair, AAPS Member Group Coordination Committee; Chair (2012–2013)
  • Decanal Review Committee; SPPS grievance committee; Chair (2012)
  • Honor‘s Program Grant Review Committee; Meet 3 times per year to review funding proposals; Grant Reviewer (2012–present)
  • NIH grant reviewer, XNDA; National Institutes of Health reviewed for XNDA section; attended study section meeting; Grant Reviewer (2011)
  • AAPS Committee - Electronic Program development committee; AAPS; Member (2011–2013)
  • AAPS Student Chapter Advisor; Faculty Liaison (2011–present)
  • SoPPS 125th Reunion Committee; To plan the 2011 reunion; Member (2010)
  • Accreditation Self-study Committee; I am chairing the Faculty Self-study for accrediation.; Chair (2010–2011)
  • Buffalo Pharmaceutics Symposium 2010 Committee; To organize one scientific symposium on Drug Transporters; Coordinator (2010)
  • AAPS Executive Committee- Member at Large; American Association of Pharmaceutical Scientists Member of Executive Committee of association; Executive Board (2009–2012)
  • PHC Controlled Drugs Committee; To manage the storage, use and licensing for all controlled drugs in the department. Tp approve new applications for use of controlled drugs.; Chair (2009–present)
  • AAPS Program Coordination Committee; American Association of Pharmaceutical Scientists Reviewed and approved workshop and webinar applications for the association.; Other (2008–2009)
  • Faculty Search Committee, Department of Pharmacology and Toxicology; To review applications, interview candidates ahd hire 6 faculty members in 2 years. 3 faculty have been hired.; Member (2008–2010)
  • UB Wellness Committee; To promote wellness at UB by programs, information; Committee Member (2008–2011)
  • AAPS J Associate Editor; AAPS Journal; Associate Editor (2008–present)
  • Biopharmaceutics and Drug Disposition Editorial Board; Biopharmaceutics and Drug Disposition; Editorial Board Member (2008–present)
  • Chair, Pharmacokinetics, Pharmacodynamics and Drug Metabolism section; American Association of Pharmaceutical Scientists Chair of the section, directing programming, awards, and all activities of the section. Implemented an Educational Initiative to support student chapters to invite AAPS fellows to their institution for se; Other (2007)
  • Nominations Committee; American Association of Pharmaceutical Scientists Reviewed and recommended nominations for leadership positions; Other (2007)
  • UB Environmental Stewartship Committee; To promote environmental sustainability.To produce a compact with plans and procedures to acheive carbon neutrality at UB. I also serve on the subcommittee for Education and Research.; Committee Member (2007–2010)
  • FDA Pharmaceutical Sciences and Clinical Pharmacology Advisory Panel; Food and Drug Administration Review specific issues and guidances for the FDA and provide scientific input.; Panel Member (2006–present)
  • Graduate School Executive Committee; Propose and discuss graduate school issues, policies and procedures.; Member (2006)
  • Associate Dean, Graduate School; As Associate Dean for Graduate and Postdoctoral Education, I head the Office for Postdoctoral Scholars and anm in volved in professional development programs and polices for graduate students and postdoctoral scholars. I also head the Office of Comprehe; Administrator (2006–2012)
  • Pharmaceutical Research Editorial Board; Pharmaceutical Research; Editorial Board Member (2005–present)
  • Past Chair of the Pharmacokinetics, Pharmacodynamics and Drug Metabolism section; American Association of Pharmaceutical Scientists On executive committee of section.; Chair (2004–2008)
  • School of Pharmacy Curriculum Committee; Address curricular issues, making recommendations to the Executive Committee.; Member (2004)
  • Clarkson University Parents Advisory Committee; Clarkson University Advised on University issues; involved with orientations, fund raising; Other (2002–2006)
  • School of Pharmacy Promotions and Tenure Committee; Review all dossiers for promotion in the School and vote.; Committee Member (2001–present)
  • Journal Of Pharmaceutical Sciences Editorial Board; Journal of Pharmaceutical Sciences; Editorial Board Member (1995–present)
  • PHC Director of Graduate Studies; Reviewed graduate applicants, graduate program policies and graduate student progress.; Director (1993–2001)
  • Outside Reviewer for promotion 2-3 per year; University promotions I generally review at least 2 dossiers a year for promotion, as an outside reviewer.; Peer Reviewer

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In the Media:

Clinical Specialties:
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Contact Information

352 Kapoor Hall
Buffalo, NY 14214-8033
Phone: (716) 645-4839
Fax: (716)829-6569
Email: memorris@buffalo.edu


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