Published December 6, 2018
A manuscript by Assistant Professor of Pharmaceutical Sciences Juliane Nguyen, PharmD, PhD, titled The Phenotypic Effects of Exosomes Secreted from Distinct Cellular Sources: a Comparative Study Based on miRNA Composition, has been selected for publication in a theme issue of the American Association of Pharmaceutical Scientists (APPS) Journal: "Pioneering Pharmaceutical Science by Emerging Investigators."
Her manuscript was one of only four selected to be recognized in the national publication.
Exosomes play a critical role in cellular communication and contain genetic information that allows them to manipulate or modulate their environment. They can contribute to the progression of cancer and many other diseases. An intriguing aspect of exosome biology is their ability to transfer genetic materials to recipient cells in the form of non-coding RNAs, especially microRNAs (miRNAs). The objective of the study was to determine how miRNA composition affects the biological functions of exosomes derived from different cellular sources using bioinformatics approaches to predict their biological effects. The findings from the study highlight that before exosomes are clinically employed as delivery vehicles, it is critical to understand their intrinsic biological activities.
Co-authors of the manuscript include Se Ra Kim, PharmD/MS '18, and pharmaceutical sciences PhD candidates Michael Deci, MS '16, Scott Ferguson, BS '13, and Christine Lee, MS '18.
As part of her recognition, Nguyen will also serve as an early-career member of the AAPS Journal Editorial Advisory Board for a two-year term.
The American Association of Pharmaceutical Scientists serves to advance the capacity of pharmaceutical scientists to develop products and therapies that improve global health. The AAPS Journal is an official journal of the American Association of Pharmaceutical Scientists and publishes novel and significant findings in the various areas of pharmaceutical sciences impacting human and veterinary therapeutics.