| Pharmaceutical Sciences |
Assistant Professor
541 Cooke Hall
Amherst NY 14260
Phone: (716) 645-4817
Fax: 716-645-3693
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Website: http://pharmacy.buffalo.edu/phc/faculty/AMYU.HTML
Email: aimingyu@buffalo.edu
Research interests lie in the field of drug metabolism and disposition. Dr. Yu‘s laboratory is interested in studying the function and regulation of
human cytochrome P450 (e.g., CYP2D6 and CYP3A4) drug-metabolizing enzymes and ATP-binding cassette (ABC) membrane transporters (e.g., BCRP/ABCG2 and
MRP1/ABCC1), and the consequent effects on pharmacokinetics and drug responses. The ultimate goal is to identify the molecular mechanisms of
interindividual variability in response to xenobiotic drugs that supports the discovery and development of new drugs, and contributes to a more
rational drug therapy.
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Role of small noncoding RNAs in the regulation of drug metabolism and disposition in cancer therapy. Understanding the function of small RNAs in
regulation of ABC transporter expression shall provide new insight into multidrug resistance, which may offer clue for the development of novel
strategy to combating drug-resistant cancers.
Pharmacogenetics in the metabolism of indolealkylamine agents and drug-drug interactions. Delineation of the genetic and environmental factors that affect
indolealkylamine metabolism, pharmacokinetics and drug effects will advance the understanding of risk factors in use of psychoactive indolealkylamine dr
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