University at Buffalo - The State University of New York
Skip to Content

Pharmacokinetic-Pharmacodynamic Modeling

Pharmacokinetic-Pharmacodynamic Modeling: Concepts and Applications
January 6-8, 2016
Paris France

Course Outline

Purpose: Current approaches in the field of PK/PD involve development of models based on mechanisms of drug action and their alteration of physiologic processes. This course will provide a ncomprehensive overview of the principles, techniques, and applications of PK/PD modeling with a partial emphasis on modeling therapeutic proteins. Such modeling allows the optimal design and interpretation of pharmacologic experiments that range from molecular biology to human responses and can expedite the drug development process. Lectures and examples from the recent literature will be provided with course notes for each participant. Selected models or examples will have a computer listing to show how to quantitate typical experimental data. At the conclusion of this course, the pharmaceutical scientist with basic knowledge in pharmacokinetics will be able to understand the diverse array of available models and begin to apply them to experimental data and to simulate anticipated drug responses.

Course Instructors

William J. Jusko, PhD

Dr. Jusko is SUNY Distinguished Professor and Chair of Pharmaceutical Sciences at the School of Pharmacy and Pharmaceutical Sciences at the University of Buffalo and received the Doctor Honoris Causae from the University of Paris Descartes in Sept. 2015. He supervises a research program on the pharmacokinetics and pharmacodynamics of immunosuppressive, anticancer, and antidiabetic drugs. and holds NIH grants in the areas of corticosteroid PK/PD and mathematical modeling. He has authored over 580 publications, consults for the FDA, NIH, and the pharmaceutical industry, and is listed in ISI Most Highly Cited in Pharmacology.

Donald E. Mager, PhD

Dr. Mager is Associate Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York. He has been a fellow of the American Foundation for Pharmaceutical Education and received the New Investigator Award in Pharmacokinetics, Pharmacodynamics, and Drug Metabolism from the American Association of Pharmaceutical Scientists in 2007. Dr. Mager serves as a Visiting Professor at the Université Paris Descartes and on the Advisory Committee on Clinical Pharmacology to the FDA. His research invokes PK/PD systems analysis to characterize drug effects, with particular interest in anti-cancer and immunomodulatory pharmacotherapy.

Course Program

Wednesday, Jan. 6

8:00
Continental breakfast

8:30-9:45
W. Jusko: Introductions: Overview, History and Highlights

9:45-10:45
D. Mager: Theory, Art, Practice of PK/PD

10:45-11:00
Break

11:00-12:00
D. Mager: Basic Pharmacology and Simple Direct Effects

12:00-13:00
Lunch

13:00-14:00
W. Jusko: Biophase Distribution

14:00-15:00
W. Jusko: Basic Indirect Response Models

15:00-15:15
Break

15:15-16:15
D. Mager: Modeling Transduction

16:15-17:00 W. Jusko Slow and Irreversible Effects

Thursday, Jan. 7

8:00
Continental breakfast

8:30-9:30
D. Mager: Review and Exercises I

9:30-10:30
W. Jusko: Chemotherapy Models

10:30-10:45
Break

10:45-12:00
W. Jusko: Complexities of Indirect Effects

12:00-13:00
Lunch

13:00-14:00
W. Jusko: Tolerance Models

14:00-15:00
D. Mager: Target-Mediated PK/PD

15:00-15:15
Break

15:15-16:15
W. Jusko: Disease Progression Models

16:15-17:15
D. Mager: Animal Scaling in PK/PD

Friday, Jan. 8

8:00
Continental breakfast

8:30-9:30
W. Jusko: Review and Exercises II

9:30-10:30
W. Jusko: Modeling Drug Interactions

10:30-10:45
Break

10:45-12:00
D. Mager: Antibody PK/PD

12:00-13:00
Lunch

13:00-14:00
D. Mager: Population PK/PD Models

14:00-15:00
W. Jusko: Computational Issues in PKPD

15:00-15:15
Break

15:15-16:15
D. Mager: Systems PK/PD Modeling

16:15-16:30
W. Jusko: Summary

"); pageTracker._trackPageview();