Reaching Others

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Dr. Marilyn E. Morris
Pharmaceutical Sciences
Professor
352 Kapoor Hall 
Buffalo NY 14214-8033
Phone: (716) 645-4839

 

Website: http://pharmacy.buffalo.edu/phc/faculty/MORR.HTML

Email: memorris@buffalo.edu

Marilyn                        E. Morris Photograph
 Research Overview

 

Research interests are focused in the areas of drug transport and pharmacokinetics/pharmacodynamics (PK/PD) of drugs.  Current research projects:

 

1. Gamma-hydroxybutyric acid (GHB) Toxicokinetics and Toxicodynamics.  GHB is a drug of abuse, known as a “club drug”.  We are characterizing the mechanisms underlying the toxicokinetics and toxicodynamics of GHB, and evaluating methods to treat overdoses of GHB.  For these studies, we are characterizing transport of GHB by Monocarboxylic Acid Transporters (MCTs), transport proteins that determine the absorption, renal clearance, and distribution of GHB throughout the body, including its distribution to the brain, the site of action.  Our goal is to devise treatment strategies to treat overdoses of GHB, in order to save lives. 

 

2. Multidrug Resistance in Breast Cancer.  Drug resistance is the main cause for therapeutic failure and death in breast cancer.  My laboratory is interested in the discovery of new classes of compounds useful in reversing multidrug resistance (MDR) to cancer chemotherapeutic agents.  One of the main causes of MDR in cancers is due to the overexpression of the efflux transport proteins, P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).  Our current studies are evaluating various dietary components, organic isothiocyanates and flavonoids, for their effects on BCRP-mediated transport and on the efficacy and toxicity of chemotherapeutic agents. 

 

3. Cancer Preventive Agents. We are investigating the effects of dietary flavonoids and organic isothiocyantes on cancer initiation and progression, and the use of these natural products in cancer prevention.  We are interested in the changes in gene expression produced by these dietary compounds and how these relate to cancer prevention.  

 

4. Biliary Excretion and Enterohepatic Cycling of Drugs.  Our research focuses on the importance of the ABC transport proteins in the biliary excretion of drugs, the in silico and in vitro methods for the prediction of biliary clearance in humans, and modeling enterohepatic cycling of drugs.

 

Limited Faculty Profile

 

Brief Statement of Experience

 

Click here for Pub Med Publications

 

 

Awards and Honors

 

Fellow, American Association for the Advancement of Science (November 2012)

 

UB Distinguished Postdoctoral Mentor Award, Graduate School (April 2012)

 

Service Award, from the Pharmacokinetics, Pharmacodynamics and Drug Metabolism Section, American Association of Pharmaceutical Scientists, November 2010

 

Faculty Service Award, Pharmacy Leadership Society , Beta Omicron Chapter, University at Buffalo, April 2010

 

Nomination for Teacher of the Year, SoPPS, January 2009

 

 

RESEARCH

 

Published Intellectual Contributions

 

Journal Article, Academic Journal (Published August 2012 Peer-Reviewed/Refereed)

Wu, F., Tamhane, M., & Morris, M. E. (2012). Pharmacokinetics, lymph node uptake, and mechanistic PK model of near-infrared dye-labeled bevacizumab after IV and SC administrationi n mice. AAPS J, 14(2), 252-61.

 

Journal Article, Academic Journal (Published July (3rd Quarter/Summer) 2012 Peer-Reviewed/Refereed)

Wu, F., Bhansali, S. G., Tamhane, M., Kumar, R., Vathy, L. A., Ding, H., Yong, K. T., Bergey, E. J., Prasad, P. N., & Morris, M. E. (2012). Noninvasive real-time fluorescence imaging of the lymphatic uptake of BSA-IRDye 680 conjugate administered subcutaneously in mice. J Pharm Sci, 101(5), 1744-54.

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

An, G., & Morris, M. E. (2012). A physiologically based pharmacokinetic model of mitoxantrpone in mice and scale-up to humans: a semi-mechanistic model incorporating DNA and protein binding. AAPS J, 14(2), 352-64.

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Roiko, S. A., Felmlee, M. A., & Morris, M. E. (2012). Brain uptake of the drug of abuse gamma-hyroxybutyric acid in rats. Drug Metab Disp, 40(1), 212-8.

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Wu, F., Bhansali, S. G., Law, W. C., Bergey, E. J., Prasad, P. N., & Morris, M. E. (2012). Fluorescence imaging of the lymph node uptake of proteins in mice after subcutaneous injection: molecular weight dependence. Pharm Res, E-pub Feb 29, 2012.

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Morse, B. L., Vijay, N., & Morris, M. E. (2012). Gamma-hydroxybutyrate (GHB)-induced respiratory depression:Combined receptor-transporter inhibition therapy for treatment of GHB overdoses. Mol Pharmacol, 2012 May 4 [E-pub].

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Morse, B. L., Felmlee, M. A., & Morris, M. E. (2012). Gamma-hydroxybutyrate blood/plasma opartitioning:effect of physiologic pH on transport by monocarboxylate transporters. Drug Metab Disp, 40(1), 64-9.

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Bhansali, S. G., Balu-Iyer, S. V., & Morris, M. E. (2012). Influence of route of administration and liposomal encapsulation on blood and lymph node exposure to the protein VEGF-C156S. J Pharm Sci, 10(2), 852-9.

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Morris, M. E., Yang, X., Gandhi, Y. A., Bhansali, S. G., & Benincosa, L. J. (2012). Interspecies scaling: prediction of human biliary clearance and comparison with QSPKR. Biopharm Drug Dispos, 33(1), 1-14.

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Richter, W. F., Bhansali, S. G., & Morris, M. E. (2012). Mechanistic determinants of biotherapeutics absorption following SC administration. AAPS J, 2012 May 23 [E-pub].

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

Gandhi, Y. A., & Morris, M. E. (2012). Re-evaluation of a quantitative structure pharmacokinetic model for biliary excretion in rats. Drug Metab Dispos, 2012 Apr20 [E-pub].

 

Journal Article, Academic Journal (Published June 2012 Peer-Reviewed/Refereed)

An, G. (2012). The sulfated conjugate of biochanin A is a substrate of breast cancer resistant protein (ABCG2). Biopharmaceutics Drug Disposition, 32(8), 446-57.

 

Journal Article, Academic Journal (Published May 2012 Peer-Reviewed/Refereed)

Moon, Y. J., Brazeau, D. A., & Morris, M. E. (2012). Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells.. Evidence-based Complementary and Alternative Medicine, 2011.

 

Book, Chapter in Textbook-New (Published January (1st Quarter/Winter) 2012 Peer-Reviewed/Refereed)

Morris, M. E. (2012). Membrane Drug Transporters. In B. L. Morse (Ed.), Foy's Priciples of Medicinal Chemistry. Lippincott Williams and Wilkins/Wolters Kluwer Health.

 

Journal Article, Academic Journal (Published May 2011)

An, G., & Morris, M. E. (2011). 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice. Pharm Res, 28(5), 1090-9.

 

Journal Article, Academic Journal (Published May 2011)

Moon, Y. J., Brazeau, D. A., & Morris, M. E. (2011). Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells.. Evidence-based Complementary and Alternative Medicine, Epub 2010 Sep 28.

 

Journal Article, Academic Journal (Published May 2011)

Telang, U., & Morris, M. E. (2011). Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.. Molecular Nutrition Food Research, 54(12), 1802-6.

 

Journal Article, Academic Journal (Published May 2011)

Tsiklauri, L., An, G., Ruszaj, D. M., Alaniya, M., Kemertelidze, E., & Morris, M. E. (2011). Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectroscopy.. J Pharm Biomed Anal., 55(1), 109-11.

 

Journal Article, Academic Journal (Published May 2011)

An, G., Gallegos, J., & Morris, M. E. (2011). The Bioflavonoid Kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated Quercetin Efflux. Drug Metab Disp, 39(3), 426-32.

 

Journal Article, Academic Journal (Published May 2011)

Felmlee, M. A., Krzyzanski, W., Morse, B. L., & Morris, M. E. (2011). Use of a Local Sensitivity Analysis to Inform Study Design Based on a Mechanistic Toxicokinetic Model for γ-Hydroxybutyric Acid. AAPS J., 13(2), 240-54.

 

Journal Article, Academic Journal (Published December 2010)

Syed Alwi, S. S., Cavell, B. E., Telang, U., Morris, M. E., Parry, B. M., & Packham, G. (2010). In vivo modulation of 4E-BP1 phosphorylation by watercress: a pilot study. Brit J Nutr, 104(9), 1288-1296.

 

Journal Article, Academic Journal (Published November 2010)

An, G., & Morris, M. E. (2010). Effects of the Isoflavonoid Biochanin A on the Transport of Mitoxantrone In Vitro and In Vivo. Biopharm Drug Dispos, 31(5-6), 340-350.

 

Journal Article, Academic Journal (Published May 2010)

An, G., Ruszaj, D. M., & Morris, M. E. (2010). Interference of a sulfate conjugate in quantitative liquid chromatography/tandem mass spectrometry through in-source dissociation. Rapid Commun Mass Spectrom, 24(12), 1817-1819..

 

Journal Article, Academic Journal (Published May 2010)

Yang, X., & Morris, M. E. (2010). Pharmacokinetics and biliary excretion of mitoxantrone in rats. J Pharm Sci, 99(5), 25o2-2510.

 

Journal Article, Academic Journal (Published April (2nd Quarter/Spring) 2010)

Yang, X., Gandhi, Y. A., & Morris, M. E. (2010). Biliary excretion in dogs: Evidence for a molecular weight threshold.. Eur J Pharm Sci., 40(1), 33-7.

 

Journal Article, Academic Journal (Published April (2nd Quarter/Spring) 2010)

An, G., & Morris, M. E. (2010). Effects of single and multiple flavonoids on BCRP-mediated accumulation, cytotoxicity and transport of mitoxantrone in vitro. Pharm Res, Apr 6. [Epub ahead of print].

 

Journal Article, Academic Journal (Published March 2010)

Felmlee, M. A., Roiko, S. A., Morse, B. L., & Morris, M. E. (2010). Concentration-effect relationships for the drug of abuse γ-hydroxybutric acid. J Pharmacol Exp Ther, Mar 9. [Epub ahead of print].

 

Journal Article, Academic Journal (Published February 2010)

An, G., & Morris, M. E. (2010). HPLC Analysis of Mitoxantrone in Mouse Plasma and Tissues: Application in a Pharmacokinetic Study. Journal of Pharmaceutical and Biomedical Analysis, 51(3), 750-753.

 

Journal Article, Academic Journal (Published September 2009)

Telang, U., Ji, Y., & Morris, M. E. (2009). ABC transporters and isothiocyanates: Potential for pharmacokinetic diet-drug interactions. Biopharm Drug Disp, 30(7), 335-344.

 

Journal Article, Academic Journal (Published September 2009)

Yang, X., Gandhi, Y. A., Duignan, D. B., & Morris, M. E. (2009). Prediction of Biliary Excretion in Rats and Humans Using. AAPS Journal, Jul 11.

 

Journal Article, Academic Journal (Published September 2009)

Gandhi, Y. A., & Morris, M. E. (2009). Quantitative structure-activity relationships for breast cancer resistance protein (ABCG2). AAPS Journal(July 24).

 

Book, Chapter in Scholarly Book-New (Published August 2009)

An, G., & Morris, M. E. (2009). Herbal Supplement-based Interactions. In K. S. Pang, A. D. Rodrigues, & R. Peter (Eds.), Enzymatic- and Transporter-Based Drug Drug Interactions: Progress and Future Challenges. Springer2009..

 

Journal Article, Academic Journal (Published June 2009)

Zhang, S., Sagawa, K., Arnold, R. D., Tseng, E., Wang, X., & Morris, M. E. (2009). Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: In vitro and in vivo. J Pharm Sci, e-pub.

 

Journal Article, Academic Journal (Published May 2009)

Pan, Y.-Z., Morris, M. E., & Yu, A. (2009). MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells. Mol Pharmacol, 75(6), 1374-1379.

 

Abstract (Published April (2nd Quarter/Spring) 2009)

Jaenecke, K., Stewart, M., Morris, M. E., Brazeau, D. A., & Havard, P. F. (2009). In A Semi-Quantitative Comparison of P-glycoprotein Protein Expression in Peripheral Blood Mononuclear Cells Between the Maternal and Fetal Compartments.  Accepted to the 2009 APhA Annual Meeting, San Antonio TX, April 3rd - 6th, 2009.. San Antonio TX.

 

Journal Article, Academic Journal (Published April (2nd Quarter/Spring) 2009)

Cui, D., & Morris, M. E. (2009). The Drug of Abuse {gamma}-Hydroxybutyrate is a Substrate for SMCT1 (SLC5A8): Characterization of SMCT-mediated Uptake and Inhibition.. Drug Metab Disp, 37(7), 1404-10.

 

Journal Article, Academic Journal (Published March 2009)

Telang, U., Brazeau, D. A., & Morris, M. E. (2009). Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.. Exp Biol Med, 234(3), 287-295.

 

Journal Article, Academic Journal (Published March 2009)

Lam, W. K., Felmlee, M. A., & Morris, M. E. (2009). Monocarboxylate Transporter (MCT)-mediated transport of {gamma}- hydroxybutyric acid in human intestinal Caco-2 cells.. Drug Metab Dispos., 38(3), 441-447.


Presentations Given

 

Conference Presentation (Academic Invited)

Morris, M. E. (2012, May). Postdoc After Graduate School. Paper presented at the National Biotechnology Conference, San Diego, CA.

 

Conference Presentation (Academic, invited)

Morris, Marilyn (Presenter), National Biotechnology Conference, "Lymphatic uptake of proteins after SC administration in rodents: In vivo fluorescence and PET as imaging tools", American Association of Pharmaceutical Scientists, San Francisco. (Published in Proceedings: Yes).

 

Poster Presentation (Academic)

Morris, Marilyn (Author), Morse, Bridget (Author & Presenter), Sigma Xi Graduate Research Conference, "Effects of Ethanol and treatment with L-lactate on GHB-induced respiratory depression.", University at Buffalo. (Published in Proceedings: No).

 

Lecture (Academic, invited)

Morris, Marilyn (Author & Presenter), Seminar Program, "Pharmacokinetics and pharmacodynamics of Gamma-hydroxybutyrate", Department of Pharmacology and Toxicology, University at Buffalo..

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author), Gandhi, Yash (Author & Presenter), Yang, Xinning (Author), American Association of Pharmaceutical Scientists Annual Meeting, "Biliary excretion in animals and humans:Re-evaluation of a molecular weight threshold", American Association of Pharmaceutical Scientistd, Los Angeles CA. (Published in Proceedings: Yes; ).

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn, Yang, Xinning (Author & Presenter), Bhansali, Suraj (Author), American Association of Pharmaceutical Scientists Annual Meeting, "Interspecies prediction of human biliary clearance based on studies in rats of multiple animal species.", American Association of Pharmaceutical Scientists, Los Angeles CA. (Published in Proceedings: Yes; ).

 

Poster Presentation (peer-reviewed)

Morris, Marilyn (Author), An, Guohua (Author & Presenter), American Association of Pharmaceutical Scientists Annual Meeting, "Transport and efflux of quercetin and biochanin A in MDCK cell monolayers-Role of efflux transporters", American Association of Pharmaceutical Scientists, Los Angeles. (Published in Proceedings: Yes; ).

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author), Bhansali, Suraj (Author & Presenter), AAPS Annual Meeting, "Physiological based pharmacokinetic model for vascular endothelial growth factor C156S (VEGF C156S) in mice", American Association of Pharmaceutical Scientists, Los Angeles CA. (Published in Proceedings: Yes; ).

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author), Felmlee, Melanie (Author & Presenter), Cui, Dapeng (Author), Cirincione, Brenda (Author), American Association of Pharmaceutical Scientists Annual Meeting, "A mechanistic pharmacokinetic model for the drug of abuse γ-hydroxybutyrate (GHB) in rats.", American Association of Pharmaceutical Scientists, Los Angeles CA. (Published in Proceedings: Yes; ).

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author), An, Guohua (Author & Presenter), AAPS Annual Meeting, "Determination of mitoxantrone in mouse plasma and tissues by an improved HPLC assay and its application in a pharmacokinetic study.", American Association of Pharmaceutical Scientists, Los Angeles CA. (Published in Proceedings: Yes; ).

 

Conference Presentation (Academic, invited)

Morris, Marilyn (Author), Telang, Urvi (Author & Presenter), Leuko, Therese (Author), AAPS Annual Meeting, "Effects of naturally-occurring breast cancer preventive agents on the metabolism of estradiol in the estrogen-responsive human breast cancer cell line MCF-7", American Association of Pharmaceutical Scientists, Los Angeles CA. (Published in Proceedings: Yes; ).

 

Conference Presentation (Academic, invited)

Morris, Marilyn, American Chemical Society Annual Meeting, "Transporter-mediated drug-herb and drug-food interactions, Symposium on Problems and Strategies in Herb/Food-Drug Interactions", American Chemical Society, Biston MA. (Published in Proceedings: Yes).

 

Conference Presentation (Academic, peer-reviewed)

Felmlee, Melanie (Author & Presenter), Morse, Bridget (Author), Roiko, Samuel (Author), Morris, Marilyn, Pharmacology Day, "Gamma-hydroxybutyratic acid, A drug of abuse, exhibits tissue specific distribution kinetics.", University at Buffalo, Amherst NY. (Published in Proceedings: Yes; ).

 

Poster Presentation (Academic, peer-reviewed)

Wu, Fang (Author & Presenter), Bhansali, Suraj (Author), Kumar, Rajiv (Author), Vathy, Lisa (Author), Bergey, Earl (Author), Morris, Marilyn (Author), National Biotechnology Conference, "Non-invasive real time quantitative imaging of lymphatic uptake of subcutaneously administered albumin in mice", American Association of Pharmaceutical Scientists, San Francisco CA. (Published in Proceedings: Yes; ).

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author), An, Guohua (Author & Presenter), Gallegos, Jorge (Author), Pharmacology Day, "The bioflavonoid kaempferol inhibits ABCG2-mediated quercetin efflux through competitive inhibition.", University at Buffalo, Amherst NY. (Published in Proceedings: Yes; ).

 

Conference Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author), Bhansali, Suraj (Author & Presenter), Balu-Iyer, Sathy, Pharmacology Day, "The pharmacokinetics and lymphatic exposure of recombinant human vascular endothelial growth factor VEGF-C156S after iv and sc administration", University at Buffalo, Buffalo NY. (Published in Proceedings: Yes; ).

 

Conference Presentation (Academic, invited)

Morris, Marilyn (Author & Presenter), North Jersey Drug Metabolism Discussion Group Spring Meeting, "Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB", American Chemical Society, Somerset, New Jersey. (Published in Proceedings: No; Published Elsewhere: Yes).

 

Lecture (Academic, invited)

Morris, Marilyn (Author & Presenter), Seminar Program for Institute on Environmental Health and Science, "Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies", Institute on Environmental Health and Science, Wayne State University, Detroit, Michigan..

 

Poster Presentation (Academic, invited)

Morris, Marilyn, Gallegos, Jorge (Author & Presenter), An, Guohua (Author), Academic Celebration of Excellence, "The bioflavonoid kaempferol inhibits ABCG2-mediated quercetin efflux through competitive inhibition.", University at Buffalo, Amherst NY. (Published in Proceedings: Yes; ).

 

Conference Presentation (Academic, invited)

Morris, Marilyn (Author & Presenter), International Society for the Study of Xenobiotics (ISSX) Annual Meeting. Short Course on Transporters in Drug Disposition and Elimination, "Intestinal transporters: bioavailability, interactions and drug delivery", ISSX, Baltimore MD. (Published in Proceedings: Yes).

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author), Bhansali, Suraj (Author & Presenter), American College of Clinical Pharmacology annual meeting, ". Development of physiological based pharmacokinetic model to predict tissue distribution of Vascular Endothelial Growth Factor C156S", American College of Clinical Pharmacology, San Antonio, Texas. (Published in Proceedings: Yes; ).

 

Poster Presentation

Felmlee, Melanie (Author & Presenter), Morris, Marilyn (Author), Boyd, Rebecca (Author), Mauer, Tristan (Author), Gao, Xiang (Author), UB-Pfizer Conference, "A Mechanistic Clinical Pharmacokinetic Model for Stains Which Are OATP1B1 Substrates and Prediction of Their Drug Interactions with Gemfibrozil", Groton CT.

 

Poster Presentation (Academic)

Felmlee, Melanie (Author & Presenter), Cui, Dapeng (Author), Cirincione, Brenda (Author), Morris, Marilyn (Author), UB-Pfizer Conference, "A Mechanistic Pharmacokinetic Model for the Drug of Abuse", Groton CT.

 

Poster Presentation (Academic)

Morris, Marilyn (Author), Bhansali, Suraj (Author & Presenter), UB-Pfizer Conference, "Development of physiological based pharmacokinetic model to predict tissue distribution of Vascular Endothelial Growth Factor C156S", Groton CT.

 

Lecture (invited)

Morris, Marilyn (Author & Presenter), "Toxicokinetics and Toxicodynamics of the drug of abuse gamma-hydroxybutyrate.", University of Georgia, Athens GA.

 

Poster Presentation (Academic)

Felmlee, Melanie (Author & Presenter), Cui, Dapeng (Author), Morris, Marilyn (Author), Pharmacology Day, "Inhibition of monocarboxylate transporters as a potential treatment strategy for γ-hydroxybutyric acid overdose.", University at Buffalo.

 

Poster Presentation

Morris, Marilyn (Author), An, Guohua (Author & Presenter), Pharmacology Day, University at Buffalo, "Transport and efflux of quercetin and biochanin A in MDCK cell monolayers -- role of efflux transporters", University at Buffalo.

 

Poster Presentation (Academic, peer-reviewed)

Felmlee, M (Author & Presenter), Cui, D (Author), Morris, Marilyn (Author), Experimental Biology annual meeting, "Characterization of sodium dependent monocarboxylate transporter-1 (SMCT1)-mediated GHB transport in FRTL-5 cells", Federation of Experimental Biology/American Assoc of Pharmacology and Experimental Therapeutics, New Orleans, LA.

 

Poster Presentation

Felmlee, Melanie (Author & Presenter), Lam, Wing Ki (Author), Morris, Marilyn (Author), Experimental Biology Annual Meeting, "Monocarboxylate transporter (MCT)-mediated transport of γ-hydroxybutyric acid in human intestinal Caco-2 cells", American Assoc of Pharmacology and Experimental Therapeutics, New Orleans  LA.

 

Poster Presentation

Wu, Fang (Author & Presenter), Bhansali, Suraj (Author), Kumar, Rajiv (Author), Vathy, Lisa (Author), Bergey, Earl (Author), Morris, Marilyn (Author), Postdoc Research Symposium, "Non-invasive real time quantitative imaging of lymphatic uptake of subcutaneously administered proteins in mice", Graduate School, University at Buffalo, Amherst NY.

 

Poster Presentation (Academic, peer-reviewed)

Havard, Patty (Author), Jaenecke, Katie (Author & Presenter), Malanie, Stewart (Author), Morris, Marilyn (Author), Brazeau, Daniel (Author), 2009 APhA Annual Meeting, "A Semi-Quantitative Comparison of P-glycoprotein Protein Expression in Peripheral Blood Mononuclear Cells Between the Maternal and Fetal Compartments.", APhA Annual Meeting, San Antonio TX..

 

Panel Member

Morris, Marilyn, Liu, JianH (Author & Presenter), An, Guohua (Author), Celebration of Excellence, "The Effect of Flavonoids on Transport of Mitoxantrone in ABCG2", UB, University at Buffalp.

 

Poster Presentation (Academic, peer-reviewed)

Morris, Marilyn (Author & Presenter), Stefanski, J (Author), Ho, John (Author), National Postdoctoral Association, "Establishment of an Office of Postdoctoral Scholars at the University at Buffalo, SUNY: Successes and Challenges.", Houston TX.

 

Conference Presentation (Academic, invited)

Morris, Marilyn (Author & Presenter), National Postdoctoral Association, "Postdoc Survival Workshop: Teaching Responsible Conduct of Research", Houston TX.

 

 

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Research interests are focused in the areas of drug transport and pharmacokinetics/pharmacodynamics (PK/PD) of drugs.  Current research projects:
1.    Gamma-hydroxybutyric acid (GHB) Toxicokinetics and Toxicodynamics.  GHB is a drug of abuse, known as a “club drug”.  We are characterizing the mechanisms underlying the toxicokinetics and toxicodynamics of GHB, and evaluating methods to treat overdoses of GHB.  For these studies, we are characterizing transport of GHB by Monocarboxylic Acid Transporters (MCTs), transport proteins that determine the absorption, renal clearance, and distribution of GHB throughout the body, including its distribution to the brain, the site of action.  Our goal is to devise treatment strategies to treat overdoses of GHB, in order to save lives.  
2.    Multidrug Resistance in Breast Cancer.  Drug resistance is the main cause for therapeutic failure and death in breast cancer.  My laboratory is interested in the discovery of new classes of compounds useful in reversing multidrug resistance (MDR) to cancer chemotherapeutic agents.  One of the main causes of MDR in cancers is due to the overexpression of the efflux transport proteins, P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).  Our current studies are evaluating various dietary components, organic isothiocyanates and flavonoids, for their effects on BCRP-mediated transport and on the efficacy and toxicity of chemotherapeutic agents.  
3.    Cancer Preventive Agents. We are investigating the effects of dietary flavonoids and organic isothiocyantes on cancer initiation and progression, and the use of these natural products in cancer prevention.  We are interested in the changes in gene expression produced by these dietary compounds and how these relate to cancer prevention.   
4.    Biliary Excretion and Enterohepatic Cycling of Drugs.  Our research focuses on the importance of the ABC transport proteins in the biliary excretion of drugs, the in silico and in vitro methods for the prediction of biliary clearance in humans, and modeling enterohepatic cycling of drugs.