Reaching Others

<<  Previous Page

 

Dr. William J. Jusko
Pharmaceutical Sciences
Chair, Pharmaceutical Sciences, SUNY Distinguished Professor
404 Kapoor Hall
Buffalo NY 14214-8033
Phone: (716) 645-2855
Fax: (716) 829-6569


Website: http://pharmacy.buffalo.edu/phc/faculty/JSKO.HTML
Email: wjjusko@buffalo.edu

 

Dr. William J. Jusko
 Research Overview

 

Research interests are in theoretical, basic, and clinical aspects of the pharmacokinetics and pharmacodynamics of various immunosuppressive agents including corticosteroids, as well as drugs used to treat diabetes, inflammation, and cancer. With Drs. Richard Almon and Debra DuBois, Dr. Jusko delves into the pharmacogenomics of diverse effects of corticosteroids and has evolved advanced mathematical models of receptor/gene-mediated responses.  They have characterized the effects of corticosteroids on hepatic and muscle enzymes and tissue responses and have evolved advanced PK/PD models for cascade-type processes. Dr. Jusko has developed mechanism-based pharmacokinetic, pharmacodynamic, and disease progression models and computational methods describing the action of various drugs and utilizes mathematical models of drug action to determine optimal dosage regimens diverse drugs.

 

Limited Faculty Profile

 

Brief Statement of Experience

 

 

DR. WILLIAM J. JUSKO, is Professor and Chairman of Pharmaceutical Sciences, received his B.S. Pharm. (1965) and Ph.D. (1970) degrees from the State University of New York at Buffalo.  He then joined the Clinical Pharmacology Section of the Boston Veterans Administration Hospital and taught in the Pharmacology Dept. of the Boston University School of Medicine.  His awards include a Fulbright-Hays Fellowship (1978), Rawls-Palmer Award from ASCPT (1987), Doctor Honoris Causae, Jagiellonian University (1987), Distinguished Service Award from ACCP (1989), and Research Achievement Award in Pharmacokinetics, Pharmacodynamics, and Drug Metabolism from

AAPS(1998). His research interests involve basic, clinical, and theoretical pharmacokinetics and pharmacodynamics with a special emphasis on corticosteroids and immunosuppressive agents.

 

Click Here for Pub Med Publications

 

 

Awards and Honors

 

ACoP Leadership Award, American Conference  on Pharmacometrics, April 2011

 

American Men and Women of Science

 

Who's Who (various venues)

 

Advisor: AAPS Graduate Student Award in PPDM - Hoi Kei Lon, AAPS (October 2012).

 

2012 Distinguished Investigator Award, ACCP: American College of Clinical Pharmacology (September 2012).

 

Sheiner-Beal Pharmacometrics Award, ASCPT. (March 2013).

 

 

RESEARCH

 

Published Intellectual Contributions

 

Journal Article, Academic Journal (Published February 22, 2013 Peer-Reviewed/Refereed)

Pawaskar, D. K., Straubinger, R. M., Fetterly, G. J., Ma, W. W., & Jusko, W. J. (2013). Interactions of Everolimus and Sorafenib in Whole Blood Lymphocyte Proliferation. Pharmaceutical Research, 30, 707-713.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 15, 2013 Peer-Reviewed/Refereed)

Dubois, D. C., Sukumaran, S., Jusko, W. J., & Almon, R. R. (2013). Evidence for a Glucocorticoid Receptor Beta Splice Variant in the Rat and Its Physiological Regulation in Liver Steroids. Steroids, 78, 312-320.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 15, 2013 Peer-Reviewed/Refereed)

Pawaskar, D. K., Straubinger, R. M., Fetterly, G. J., Ma, W. W., & Jusko, W. J. (2013). Interactions of Everolimus and Sorafenib in Pancreatic Cancer Cells. AAPSJ, 15, 78-84.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 15, 2013 Peer-Reviewed/Refereed)

Fang, J., Landersdorfer, C. B., Cirincione, B., & Jusko, W. J. (2013). Study Reanalysis Using a Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes. AAPSJ, 15, 15-29.

 

Journal Article, Academic Journal (Published December 15, 2012 Peer-Reviewed/Refereed)

Cao, Y., & Jusko, W. J. (2012). Applications of Minimal Physiologically-Based Pharmacokinetic Models. Journal of Pharmacokinetics & Pharmacodynamics, 39, 711-723.

 

Journal Article, Academic Journal (Published December 15, 2012 Peer-Reviewed/Refereed)

Almon, R. R., Dubois, D. C., Sukumaran, S., Wang, X., Xue, B., Nie, J., & Jusko, W. J. (2012). Effects of High Fat Feeding on Liver Gene Expression in Diabetic Goto-Kakizaki Rats. Gene Regulation and Systems Biology, 6, 151-168.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 15, 2012 Peer-Reviewed/Refereed)

Lon, H.-K., Liu, D., & Jusko, W. J. (2012). Pharmacokinetic/Pharmacodynamic Modeling in Inflammation. Critical Reviews in Biomedical Engineering, 40, 295-312.

 

Book, Chapter in Scholarly Book-New (Published October (4th Quarter/Autumn) 1, 2012 Peer-Reviewed/Refereed)

Sukumaran, S., Dubois, D. C., Jusko, W. J., & Almon, R. R. (2012). Glucocorticoid Effects on Adiponectin Expression in Adiponectin. In G. Litwack (Ed.), Adiponectin, Vitamins & Hormones Series (ed., vol. 90, pp. 163-186). Elsevier Inc..

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2012 Peer-Reviewed/Refereed)

Sukumaran, S., Lepist, E.-I., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2012). Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPSInduced Inflammation in Rats. Pharmaceutical Research, 29, 2060-2069.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2012 Peer-Reviewed/Refereed)

Cao, Y., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2012). Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats. Biopharmaceutics & Drug Disposition, 33, 285-291.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2012 Peer-Reviewed/Refereed)

Jusko, W. J. (2012). Use of Pharmacokinetic Data Below Lower Limit of Quantitation Values. Pharmaceutical Research, 29, 2628-2631.

 

Journal Article, Academic Journal (Published May 15, 2012 Peer-Reviewed/Refereed)

Gao, W., & Jusko, W. J. (2012). Modeling Disease Progression and Rosiglitazone Intervention in Type 2 Diabetic Goto-Kakizaki Rats. Journal of Pharmacology & Experimental Therapeutics, 341, 617-625.

 

Journal Article, Academic Journal (Published May 1, 2012 Peer-Reviewed/Refereed)

Gao, W., & Jusko, W. J. (2012). Target-Mediated Pharmacokinetic and Pharmacodynamic Model of Exendin-4 in Rats, Monkeys and Man. Drug Metabolism & Disposition, 40, 990-997.

 

Journal Article, Academic Journal (Published March 26, 2012 Peer-Reviewed/Refereed)

Landersdorfer, C. B., He, Y.-L., & Jusko, W. J. (2012). Mechanism-Based Population Modelling of the Effects of Vildagliptin on GLP-1, Glucose and Insulin in Patients with Type 2 Diabetes. British Journal of Clinical Pharmacology, 73, 373-390.

 

Journal Article, Academic Journal (Published March 26, 2012 Peer-Reviewed/Refereed)

Landersdorfer, C. B., He, Y.-L., & Jusko, W. J. (2012). Mechanism-Based Population Pharmacokinetic Modelling in Diabetes:  Vildagliptin as a Tight Binding Inhibitor and Substrate of Dipeptidyl Peptidase IV. British Journal of Clinical Pharmacology, 73, 391-401.

 

Journal Article, Academic Journal (Published March 9, 2012 Peer-Reviewed/Refereed)

Cao, Y., & Jusko, W. J. (2012). Pharmacokinetic/Pharmacodynamic Modeling of GLP-1 in Healthy Rats. Pharmaceutical Research, 29, 1078-1086.

 

Journal Article, Academic Journal (Published December 5, 2011)

Cao, Y., Dubois, D. C., Sun, H., Almon, R. R., & Jusko, W. J. (2011). Modeling Diabetes Disease Progression and Salsalate Intervention in Goto-Kakizaki Rats. Pharmaceutical Research, 339, 896-904.

 

Journal Article, Academic Journal (Published December 1, 2011)

Møller, J. B., Jusko, W. J., Gao, W., Hansen, T., Pedersen, O., Holst, J. J., Overgaard, R. V., Madsen, H., & Ingwersen, S. H. (2011). Mechanism-Based Population Modelling for Assessment of L-Cell Function Based on Total GLP-1 Response Following an Oral Glucose Tolerance Test. Journal of Pharmacokinetics and Pharmacodynamics, 38, 713-725.

 

Journal Article, Academic Journal (Published December 1, 2011)

Liu, D., Lon, H.-K., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2011). Population Pharmacokinetic - Pharmacodynamic - Disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-Induced Arthritis. Journal of Pharmacokinetics and Pharmacodynamics, 38, 769-786.

 

Journal Article, Academic Journal (Published June 1, 2011)

Sukumaran, S., Jusko, W. J., Dubois, D. C., & Almon, R. R. (2011). LIGHT/ DARK OSCILLATIONS IN THE LUNG TRANSCRIPTOME: IMPLICATIONS 2 FOR LUNG HOMEOSTASIS, REPAIR, METABOLISM, DISEASE AND DRUG 3 ACTION. J Appl Physiol, 110, 1732-1747.

 

Journal Article, Academic Journal (Published May 1, 2011)

Nie, J., Bai, B., Sukumaran, S., Jusko, W. J., Dubois, D. C., & Almon, R. R. (2011). Differential Muscle Gene Expression as a Function of Disease Progression in Goto-Kakizaki Diabetic Rats. Molecular and Cellular Endocrinology, 338, 10-17.

 

Journal Article, Academic Journal (Published April (2nd Quarter/Spring) 1, 2011)

Fang, J., Dubois, D. C., He, Y., Almon, R. R., & Jusko, W. J. (2011). Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats. J Pharmacokinet Pharmacodyn, 38, 293-316.

 

Journal Article, Academic Journal (Published April (2nd Quarter/Spring) 1, 2011)

Sukumaran, S., Jusko, W. J., Dubois, D. C., & Almon, R. R. (2011). MECHANISTIC MODELING OF THE EFFECTS OF GLUCOCORTICOIDS AND CIRCADIAN RHYTHMS ON ADIPOKINE EXPRESSION. J. Pharmacol. Exp. Ther., 337, 734-746.

 

Journal Article, Academic Journal (Published April (2nd Quarter/Spring) 1, 2011)

Lon, H.-K., Liu, D., Zhang, Q., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2011). Pharmacokinetic-Pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis. Pharmaceutical Research, 28, 1622-1630.

 

Journal Article, Academic Journal (Published April (2nd Quarter/Spring) 1, 2011)

Bai, J. P. F., Bell, R., Buckman, S., Burckart, G. J., Eichler, H.-G., Fang, K. C., Goodsaid, F. M., Jusko, W. J., Lesko, L. L., Meibohm, B., Patterson, S. D., Puig, O., Smerage, J. B., Snider, B. J., Wagner, J. A., Wang, J., Walton, M. K., & Weiner, R. (2011). Translational Biomarkers:  From Preclinical to Clinical, A Report of 2009 AAPS/ACCP Biomarker Workshop. The AAPS Journal, 13, 274-283.

 

Journal Article, Academic Journal (Published February 25, 2011)

Xue, B., Sukumaran, S., Nie, J., Jusko, W. J., Dubois, D. C., & Almon, R. R. (2011). Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats. PLoS ONE, 6(2), e17386.

 

Journal Article, Academic Journal (Published February 15, 2011)

Gao, W., & Jusko, W. J. (2011). Pharmacokinetic and Pharmacodynamic Modeling of Exendin-4 in Type 2 Diabetic Goto-Kakizaki Rats. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 336, 881-890.

 

Journal Article, Academic Journal (Published February 1, 2011)

Gao, W., Bihorel, S., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2011). Mechanism-Based Disease Progression Modeling of Type 2 Diabetes in Goto-Kakizaki Rats. J Pharmacokinet Pharmacodyn, 38, 143-162.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 14, 2011)

Scheff, J. D., Almon, R. R., Dubois, D. C., Jusko, W. J., & Androulakis, I. P. (2011). Assessment of Pharmacologic Area Under the Curve when Baselines are Variable. Pharmaceutical Research, 28, 1081-1089.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 1, 2011)

Nie, J., Dubois, D. C., Jusko, W. J., & Almon, R. R. (2011). Mechanistic Population Modeling of Diabetes Disease Progression in Goto-Kakizaki Rat Muscle. BIOPHARMACEUTICS & DRUG DISPOSITION, 32, 50-63.

 

Journal Article, Academic Journal (Published November 1, 2010)

Ovacik, M. A., Sukumaran, S., Almon, R. R., Dubois, D. C., Jusko, W. J., & Androulakis, I. P. (2010). Circadian Signatures in Rat Liver:  From Gene Expression to Pathways. BMC Bioinformatics, 11, 540.

 

Journal Article, Academic Journal (Published November 1, 2010)

Sukumaran, S., Xue, B., Jusko, W. J., Dubois, D. C., & Almon, R. R. (2010). Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology. Physiol Genomics, 42A, 141-152.

 

Journal Article, Academic Journal (Published November 1, 2010)

Jusko, W. J., Hale, G., Rebello, P., Al Bakir, I., Bolam, E., Wiczling, P., Vandemeulebroucke, E., Keymeulen, B., Mathieu, C., Ziegler, A.-G., Chatenoud, C., & Waldmann, H. (2010). Pharmacokinetics and Antibody Responses to the CD3 Antibody Otelixizumab Used in the Treatment of Type 1 Diabetes. The Journal of Clinical Pharmacology, 50, 1238-1248.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2010)

Scheff, J. D., Almon, R. R., Dubois, D. C., Jusko, W. J., & Androulakis, I. P. (2010). A New Symbolic Representation for the Identification of Informative Genes in Replicated Microarray Experiments. OMICS A Journal of Integrative Biology, 14(3), 239-248.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2010)

Sukumaran, S., Almon, R. R., Dubois, D. C., & Jusko, W. J. (2010). Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Advanced Drug Delivery Reviews, 62, 904-917.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2010)

Nguyen, T. T., Almon, R. R., Dubois, D. C., Jusko, W. J., & Androulakis, I. P. (2010). Comparative Analysis of Acute and Chronic Corticosteroid Pharmacogenomic Effects in Rat Liver:  Transcriptional Dynamics and Regulatory Structures. BMC Bioinformatics, 11, 515.

 

Journal Article, Academic Journal (Published September 30, 2010)

Landersdorfer, C. B., & Jusko, W. J. (2010). Pharmacokinetic/Pharmacodynamic Modeling of Glucose Clamp Effects of Inhaled and Subcutaneous Insulin in Healthy Volunteers and Diabetic Patients. Drug Metab. Pharmacokinet., 25(5), 418-429.

 

Journal Article, Academic Journal (Published July (3rd Quarter/Summer) 1, 2010)

Ghoshal, S., Rao, I., Earp, J. C., Jusko, W. J., & Wetzler, M. (2010). Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity. Cancer Chemotherapy Pharmacology, 66, 681-689.

 

Journal Article, Academic Journal (Published July (3rd Quarter/Summer) 1, 2010)

Findling, R. L., Landersdorfer, C. B., Kafantaris, V., Pavuluri, M., McNamara, N. K., McClellan, J., Frazier, J. A., Sikich, L., Kowatch, R., Lingler, J., Faber, J., Taylor-Zapata, P., & Jusko, W. J. (2010). First-Dose Pharmacokinetics of Lithium Carbonate in Children and Adolescents. Journal of Clinical Psychopharmacology, 30(4), 404-410.

 

Journal Article, Academic Journal (Published July (3rd Quarter/Summer) 1, 2010)

Nguyen, T. T., Almon, R. R., Dubois, D. C., Jusko, W. J., & Androulakis, I. P. (2010). Importance of replication in analyzing time-series gene expression data: Corticosteroid dynamics and circadian patterns in rat liver. BMC Bioinformatics, 11(279), 1-15.

 

Journal Article, Academic Journal (Published May 11, 2010)

Wiczling, P., Rosenzweig, M., Vaickus, L., & Jusko, W. J. (2010). Pharmacokinetics and Pharmacodynamics of a Chimeric/Humanized Anti-CD3 Monoclonal Antibody, Otelixizumab (TRX4), in Subjects with Psoriasis and with Type 1 Diabetes Mellitus. Journal of Clinical Pharmacology, 50, 494-506.

 

Journal Article, Academic Journal (Published May 1, 2010)

Bulitta, J. B., Yang, J. C., Yohonn, L., Ly, N. S., Brown, S. V., D'Hondt, R. E., Jusko, W. J., Forrest, A., & Tsuji, B. T. (2010). Attenuation of Colistin Bactericidal Activity by High Incoulum of Pseudomonas Aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model. Antimicrobial Agents and Chemotherapy, 54, 2051-2062.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 1, 2010)

Freishtat, R. J., Nagaraju, K., Jusko, W. J., & Hoffman, E. P. (2010). Glucocorticoid Efficacy in Asthma:  Is Improved Tissue Remodeling Upstream of Anti-Inflammation. Journal of Investigative Medicine, 58, 19-22.

 

Journal Article, Academic Journal (Published December 1, 2009)

Khinkis, L. A., Krzyzanski, W., Jusko, W. J., & Greco, W. R. (2009). D-Optimal Designs for Parameter Estimation for Indirect Pharmacodynamic Response Models. J Pharmacokinet Pharmacodyn, 36, 523-529.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2009)

Bulitta, J. B., Zhao, P., Arnold, R. D., Kessler, D. R., Daifuku, R., Pratt, J., Luciano, G., Hanauske, A.-R., Gelderblom, H., Awada, A., & Jusko, W. J. (2009). Mechanistic Population Pharmacokinetics of Total and Unbound Paclitaxel for a New Nanodroplet Formulation vs. Taxol in Cancer Patients. Cancer Chemother Pharmacol, 63, 1049-1063.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2009)

Woo, S., Pawaskar, D., & Jusko, W. J. (2009). Methods of Utilizing Baseline Values for Indirect Response Models. J Pharmacokinet Pharmacodyn, 36, 381-405.

 

Journal Article, Academic Journal (Published October (4th Quarter/Autumn) 1, 2009)

Bulitta, J. B., Zhao, P., Arnold, R. D., Kessler, D. R., Daifuku, R., Pratt, J., Luciano, G., Hanauske, A.-R., Gelderblom, H., Awada, A., & Jusko, W. J. (2009). Multiple-Pool Lifespan Models for Neutropenia to Assess the Population Pharmacodynamics of Unbound Paclitaxel from Two Formulations in Cancer Patients. Cancer Chemother Pharmacol, 63, 1035-1048.

 

Journal Article, Academic Journal (Published August 1, 2009)

Yang, E. H., Almon, R. R., Dubois, D. C., Jusko, W. J., & Androulakis, I. P. (2009). Identification of Global Transcriptional Dynamics. PLoS ONE, 4(7), e5992.

 

Journal Article, Academic Journal (Published August 1, 2009)

Cho, H.-Y., Blum, R. A., Sunderland, T., Cooper, G. J. S., & Jusko, W. J. (2009). Pharmacokinetic and Pharmacodynamic Modeling of a Copper-Selective Chelator (TETA) in Healthy Adults. The Journal of Clinical Pharmacology, 49, 916-928.

 

Journal Article, Academic Journal (Published March 2009)

Almon, R. R., Dubois, D. C., Lai, W., Xue, B., Nie, J., & Jusko, W. J. (2009). Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats.. J Endocrinol, 200, 331-346.

 

Journal Article, Academic Journal (Published February 2009)

Landersdorfer, C. B., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2009). Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats.. J Pharmacol Exp Ther, 328, 644-651.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 20, 2009)

Jin, J. Y., & Jusko, W. J. (2009). Pharmacodynamics of Glucose Regulation by Methylprednisolone.  II. Normal Rats. Biopharm. Drug Disp., 30, 35-48.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 2009)

Bulitta, J. B., Ly, N. S., Yang, J. C., Forrest, A., Jusko, W. J., & Tsuji, B. T. (2009). Development and Qualification of a Pharmacodynamic Model for the Pronounced Inoculum Effect of Ceftazidime against Pseudomonas aeruginosa. Antimicrob. Ag. Chemother., 53(1), 46-56.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 2009)

Jin, J. Y. (2009). Pharmacodynamics of Glucose Regulation by Methylprednisolone. I. Adrenalectomized Rats. Biopharm. Drug Disp., 30, 21-34.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 2009)

Earp, J. C., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2009). Quantitative dynamic models of arthritis progression in the rat.. Pharm Res, 26, 196-203.

 

Journal Article, Academic Journal (Published January (1st Quarter/Winter) 2009)

Mager, D. E., Woo, S., & Jusko, W. J. (2009). Scaling Pharmacodynamics from In Vitro and Preclinical Animal Studies to Humans. Drug Metab. Pharmacokin., 24(1), 16-24.

 


Presentations Given

 

Poster Presentation (Academic Invited)

Jusko, W. J., Elmeliegy, M., Den Haese, J., Talati, C., & Wetzler, M. (2013, June). CELL CYCLE MODELING OFFERS A PLATFORM TO OPTIMIZE COMBINATION OF CYTARABINE AND FLT3 INHIBITORS IN ACUTE MYELOID LEUKEMIA. Poster presented at the Congress of the European Hematology Association, Stockholm, Sweden.

 

Conference Presentation (Academic Invited)

Jusko, W. J. (2013, March). Evolution of Mechanistic PK/PD Modeling - Our Future?. Paper presented at the ASCPT 2013 Annual Meeting, Indianapolis, IN.

 

Poster Presentation (Academic Invited)

Jusko, W. J., Elmeliegy, M. A., Den Haese, J., Talati, C., & Wetzler, M. (2013, March). PHARMACODYNAMIC MODELING OF CELL CYCLE EFFECTS OF CYTARABINE AND FLT3 INHIBITORS ON ACUTE MYELOID LEUKEMIA CELLS. Poster presented at the ASCPT 2013 Annual Meeting, Indianapolis, IN.

 

Lecture (Academic Invited)

Jusko, W. J. (2012, November). Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics:  Lessons From Corticosteroids. Presented at the Biomedical Research Institute, Gwangju, South Korea.

 

Lecture (Academic Invited)

Jusko, W. J. (2012, November). Moving PK/PD from Basic Towards Systems Pharmacology. Presented at the 2012 International Conference of the Korean Society of Pharmaceutical Sciences and Technology (KSPST), Gwangju, South Korea.

 

Lecture (Academic Invited)

Jusko, W. J. (2012, November). Applications of Minimal Physiologically-Based Pharmacokinetic Models. Presented at the Research Institute of Pharmaceutical Sciences, Seoul, South Korea.

 

Lecture (Academic Invited)

Jusko, W. J. (2012, November). Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics:  Lessons From Corticosteroids. Presented at the The Catholic University of Korea School of Medicine, Seoul, South Korea.

 

Poster Presentation (Academic Peer-Reviewed)

Jusko, W. J., & Cao, Y. (2012, October). Application of Minimal Physiologically-based Pharmacokinetic Models. Poster presented at the 2012 AAPS Annual Meeting and Exposition, Chicago, IL.

 

Poster Presentation (Academic Peer-Reviewed)

Jusko, W. J., Yoo, H., Iirola, T., Vilo, S., Manner, T., Aantaa, R., Lahtinen, M., Scheinin, M., & Olkkola, K. T. (2012, October). Mechanism-based Population Pharmacokinetic and Pharmacodynamic Modeling of Intravenous and Intranasal Dexmedetomidine. Poster presented at the 2012 AAPS Annual Meeting and Exposition, Chicago, IL.

 

Poster Presentation (Academic Peer-Reviewed)

Jusko, W. J., Lon, H.-K., Earp, J., Dubois, D. C., & Almon, R. R. (2012, October). Modeling Effects of Dexamethasone on Disease Progression of Bone Mineral Density in Collagen-induced Arthritic Rats. Poster presented at the 2012 AAPS Annual Meeting and Exposition, Chicago, IL.

 

Poster Presentation (Academic Peer-Reviewed)

Jusko, W. J., He, Y., & Brunstrom, J. (2012, October). Population Pharmacokinetics Analysis of Orally Administrated Baclofen in Pediatric Patients with Cerebral Palsy. Poster presented at the 2012 AAPS Annual Meeting and Exposition, Chicago, IL.

 

Poster Presentation (Academic Peer-Reviewed)

Jusko, W. J., Sukumaran, S., Nouri-Nigjeh, E., Li, J., Yu, H., Dubois, D. C., Almon, R. R., & Qu, J. (2012, October). Proteome-level Pharmacokinetic/Pharmacodynamic Analysis of Corticosteroid-responsive Proteins in Rat Liver. Poster presented at the 2012 AAPS Annual Meeting and Exposition, Chicago, IL.

 

Conference Presentation (Academic Invited)

Jusko, W. J. (2012, September). Pharmacokinetics/Pharmacodynamics/Pharmacogenomics: Lessons from Corticosteroids. Paper presented at the 2012 American College of Clinical Pharmacology (ACCP) Annual Meeting, San Diego, CA.

 

Keynote Presentation (Academic Invited)

Jusko, W. J. (2012, September). Moving PK/PD from Basic towards Systems Pharmacology. Keynote presentation at the 2012 American College of Clinical Pharmacology (ACCP) Annual Meeting, San Diego, CA.

 

Poster Presentation (Academic Peer-Reviewed)

Qu, J., Nouri-Nigjeh, E., Li, J., Yu, H., Sukumaran, S., Dubois, D. C., Almon, R. R., & Jusko, W. J. (2012, September). Extensive, proteome-level investigation of the corticosteroid pharmacodynamics with 12 time points using a reproducible and comprehensive ion-current-based profiling strategy. Poster presented at the HUPO 2012 11th Annual World Congress, Boston, MA.

 

Poster Presentation (Academic Peer-Reviewed)

Jusko, W. J., Steiner, R., Shah, A., Ho, S., Steinberg, S., & Awdishu, L. (2012, June). Prednisone Dose and Exposure in Chronic Renal Transplant Recipients: One Size Does NOT Fit All. Poster presented at the American Transplant Congress, Boston, MA.

 

Poster Presentation (Academic Peer-Reviewed)

Jusko, W. J., Steiner, R., Ho, S., Shah, A., Steinberg, S., & Awdishu, L. (2012, June). Take it With Breakfast: But Does Food Reduce Prednisone Exposure As Much As It Reduces CNI Exposure in Renal Transplant Patients?. Poster presented at the American Transplant Congress, Boston, MA.

 

Poster Presentation (Academic Not Invited or Peer-Reviewed)

Jusko, W. J., Yoo, H., Iirola, T., Vilo, S., Manner, T., Aantaa, R., Lahtinen, M., Scheinin, M., & Olkkola, K. T. (2012, April). Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine. Poster presented at the 4th Annual UB Postdoc Research Symposium, Buffalo, NY.

 

Poster Presentation (Academic Not Invited or Peer-Reviewed)

Jusko, W. J., Gao, W., & Cao, Y. (2012, April). Pharmacokinetic/Pharmacodynamic Modeling of GLP-1 in Healthy Rats. Poster presented at the 4th Annual UB Postdoc Research Symposium, Buffalo, NY.

 

Poster Presentation (Academic Not Invited or Peer-Reviewed)

Jusko, W. J., Sukumaran, S., Lepist, E.-I., Dubois, D. C., & Almon, R. R. (2012, April). Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-Induced Inflammation in Rats. Poster presented at the 4th Annual UB Postdoc Research Symposium, Buffalo, NY.

 

Poster Presentation (Academic Peer-Reviewed)

Roy Chaudhury, T., Straubinger, N., Pitoniak, R., Hylander, B., Jusko, W. J., Ma, W. W., Repasky, E., & Straubinger, R. M. (2012, April). Effects of sonic hedgehog inhibitor combined with nanoparticulate drug delivery on vascular permeability and efficacy in a pancreatic cancer model.. Poster presented at the American Association for Cancer Research, Chicago, IL.

 

Poster Presentation (Academic Peer-Reviewed)

Pawaskar, D., Straubinger, R. M., Fetterly, G., Hylander, B., Repasky, E., Ma, W. W., & Jusko, W. J. (2012, April). Multi-scale assessment of Everolimus and Sorafenib Combination in Pancreatic Cancer. Poster presented at the American Association for Cancer Research, Chicago, IL.

 

Conference Presentation (Academic Not Invited or Peer-Reviewed)

Jusko, W. J. (2012, January). What We Do in Pharmaceutical Sciences. Paper presented at the UB Biology Honors Program, University at Buffalo.

 

Conference Presentation (Academic Invited)

Jusko, W. J. (2012, January). PK/PD/Disease Modeling in Cancer Chemotherapy. Paper presented at the Hoffman La Roche, Basel, Switzerland.

 

Webinar (Academic, invited)

Jusko, William (Author & Presenter), Impact of Modeling & Simulation in Drug Development, "Moving PK/PD From Basic Towards Systems Pharmacology", Rosa & Co. LLC., Buffalo, NY..

 

Conference Presentation (Academic, invited)

Jusko, William (Author & Presenter), He, Yang (Author & Presenter), Pediatric Neurology Cerebral Palsy Center, "Population PK and PD Analysis of Oral Baclofen in Pediatric Patients with Cerebral Palsy", Pediatric Neurology Cerebral Palsy Center, Washington University School of Medicine, St. Louis Children's Hospital, Missouri.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Sukumaran, Siddharth (Author & Presenter), Xue, Bai (Author), Dubois, Debra (Author), Almon, Richard (Author), 2011 AAPS Annual Meeting and Exposition, "Mechanistic Modeling of Tissue-specific Effects of Corticosteroids and Circadian Rhythms on Phosphoenolpyruvate Carboxykinase Expression in Rat Liver and Adipose Tissue", AAPS, Washington, DC.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Cao, Yangyuang (Author & Presenter), Sun, Hao (Author), Dubois, Debra (Author), Almon, Richard (Author), 2011 AAPS Annual Meeting and Exposition, "Modeling Diabetes Disease Progression and Salsalate Intervention in Goto-Kakizaski Rats", AAPS, Washington, DC.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Lon, Hoi Kei (Cecelia) (Author & Presenter), Liu, Dongyang (Author), Dubois, Debra (Author), Almon, Richard (Author), 2011 AAPS Annual Meeting and Exposition, "Modeling Pharmacokinetics/Pharmacodynamics of Abatacept and Disease Progression in Collagen-induced Arthritic Rats - A Population Approach", AAPS, Washington, DC.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Liu, Dongyang (Author & Presenter), Lon, Hoi Kei (Cecelia) (Author), Dubois, Debra (Author), Almon, Richard (Author), 2011 AAPS Annual Meeting and Exposition, "Population Pharmacokinetic-Pharmacodynamic-Disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis", AAPS, Washington, DC.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Pawaskar, Dipti (Author & Presenter), Straubinger, Robert (Author), Fetterly, Gerald (Author), 2011 AAPS Annual Meeting and Exposition, "Population Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Pancreatic Cancer Xenograft Mice", AAPS, Washington, DC.

 

Conference Presentation (Academic, peer-reviewed)

Jusko, William (Author & Presenter), 2011 AAPS Annual Meeting and Exposition, "The Relevance of Chronobiology in PK/PD", AAPS, Washington, DC.

 

Conference Presentation (Academic, invited)

Jusko, William (Author), Ma, Wen Wee (Author & Presenter), Pawaskar, Dipti (Author & Presenter), Straubinger, Robert (Author), Fetterly, Gerald (Author), Clinical and Translational Research Colloquium, "Systems Pharmacological Analysis of Molecularly Targeted Agents in Pancreatic Cancer:  Pharmacodynamic Design of Novel Therapeutic Trails", University at Buffalo, Zebro Conference Room, Buffalo Niagara Medical Campus, Buffalo NY..

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Moller, Jonas (Author & Presenter), Gao, Wei (Author), Hansen, Torben (Author), Pedersen, Oluf (Author), Holst, Jens (Author), Overgaard, Rune (Author), Madsen, Henrik (Author), Ingwersen, Steen (Author), 2011 PAGE Meeting, "Assessment of L-Cell Function Based on GLP-1 Response in an Oral Glucose Tolerance Test", PAGE, Athens, Greece.

 

Poster Presentation (Academic)

Jusko, William (Author), Cao, Y. (Author & Presenter), Post-Doctoral Fellowship Day, "Modeling type 2 diabetes progression in newly diagnosed patients", University at Buffalo, Buffalo, NY.

 

Poster Presentation (Academic)

Jusko, William (Author), Liu, D. (Author & Presenter), Lon, H.K. (Author), Dubois, Debra (Author), Almon, Richard (Author), Post-Doctoral Fellowship Day, "Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis", University at Buffalo, Buffalo, NY.

 

Poster Presentation (Academic)

Jusko, William (Author), Sun, H. (Author & Presenter), Cao, Y. (Author), Dubois, Debra (Author), Almon, Richard (Author), Pharmaceutical Sciences Poster Day, "Modeling Diabetes Progression in Goto-Kakizaki Rat and Salsalate Intervention", University at Buffalo, Buffalo, NY.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Sukumaran, Siddharth (Author & Presenter), Dubois, Debra (Author), Almon, Richard (Author), EXPERIMENTAL BIOLOGY 2011, "Genome-wide analysis of circadian oscillations in gene expression in lung and its implications in lung homeostasis, repair and diseases", APS, Washington, DC. (Published in Proceedings: Yes).

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Pawaskar, D. (Author & Presenter), Straubinger, Robert (Author), Fetterly, J. (Author), Ma, W.W. (Author), American Association for Cancer Research, "Physiologically-Based Pharmacokinetics and Interactions of Everolimus and Sorafenib in Mice", AACR, Orlando, FL.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Pawaskar, D. (Author & Presenter), Straubinger, Robert (Author), Fetterly, J. (Author), Ma, W.W. (Author), AAPS Annual Meeting and Exposition, "Modeling chemotherapeutic interactions of sorafenib and everolimus effects on pancreatic cancer cells", AAPS, New Orleans, LA.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Pawaskar, Dipti (Author & Presenter), Straubinger, Robert (Author), Fetterly, Gerald (Author), Ma, Wen (Author), AAPS Annual Meeting and Exposition, "Pharmacodynamic Interaction of Everolimus and Sorafenib Using In Vitro Whole Blood Lymphocyte Proliferation", AAPS, New Orleans, Louisiana, USA..

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Lon, H.K. (Author & Presenter), Liu, D. (Author), Zhang, Q. (Author), Dubois, Debra (Author), Almon, Richard (Author), AAPS Annual Meeting and Exposition, "Pharmacokinetic - Pharmacodynamic – Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis", AAPS, New Orleans, LA.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Fang, Jing (Author & Presenter), Landersdorfer, Cornelia (Author), Cirincione, Brenda (Author), AAPS Annual Meeting and Exposition, "Mechanism-Based PK/PD Model of Pramlintide in Patients with Type 1 Diabetes", AAPS, New Orleans, Louisiana, USA..

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Lon, Hoi Kei (Author & Presenter), Zhang, Nancy (Author), Lui, Dongyang (Author), Dubois, Debra (Author), Almon, Richard (Author), AAPS Annual Meeting and Exposition, "Pharmacokinetic-Pharmacodynamic-Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis", AAPS, New Orleans, Louisiana, USA..

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Gao, W. (Author & Presenter), AAPS Annual Meeting and Exposition, "Pharmacokinetics and Pharmacodynamics of Rosiglitazone in Type 2 Diabetic Goto-Gakizaki (GK) Rats", AAPS, New Orleans, LA.

 

Conference Presentation (Academic, invited)

Jusko, William (Presenter), AAPS Annual Meeting and Exposition, "The Development of Mechanistic Population Pharmacokinetic Models to Support the Development of Targeted Release Characteristics from Modified Release Dosage Forms", AAPS, New Orleans, Louisiana, USA..

 

Poster Presentation (Academic)

Jusko, William (Author), Cao, Y. (Author & Presenter), Gao, W. (Author), Cirincione, B. (Author), 12th Buffalo Pharmaceutics Symposium, "Pharmacokinetic/Pharmacodynamic modeling of GLP-1 in healthy rats", University at Buffalo, Buffalo, NY.

 

Conference Presentation (Academic, invited)

Jusko, William (Presenter), Meeting of the Center for Protein Therapeutics, "PK/PD Modeling of Etanercept".

 

Lecture (Academic)

Jusko, William (Presenter), 12th Buffalo Pharmaceutics Symposium, "Department Highlights & Introduction and Historical Perspectives of PK/PD", University at Buffalo, Buffalo, NY.

 

Conference Presentation (Academic, invited)

Jusko, William (Presenter), 2010 Best Pharmaceuticals for Children Act Annual Meeting, "Pediatric Pharmacokinetics: Lithium, Baclofen, and Hydroxyurea", National Institute of Child Health and Human Development & National Institutes of Health, Rockville, Maryland..

 

Poster Presentation (Academic)

Jusko, William (Author), Lon, H.K. (Presenter), Liu, D. (Author & Presenter), Zhang, Q. (Author), Dubois, Debra (Author), Almon, Richard (Author), Annual Pharmaceutics Graduate Student Research Meeting, "Pharmacokinetic - Pharmacodynamic – Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis", The Ohio State University.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Wiczling, Pawel (Author & Presenter), Rosenzweig, Michael (Author), Vaickus, Louis (Author), The Annual Meeting of the Population Approach Group in Europe, "Pharmacokinetics and Pharmacodynamics of Anti-CD3 Monoclonal Antibody, Otelixizumab in Subjects with Diabetes and Psoriasis", Population Approach Group in Europe, Berlin, Germany.

 

Organized and Presented 11 Lectures at our Annual PK/PD Modeling Course (Academic)

Jusko, William (Author & Presenter), Annual Course in PK/PD Modeling, "Various", University at Buffalo, Buffalo, NY.

 

Poster Presentation (Academic)

Jusko, William (Author), Pawaskar, Dipti (Presenter), Straubinger, Robert (Author), Fetterly, Gerald (Author), Ma, Wen (Author), Pharmacology Day 2010, "Pharmacodynamic Interaction of Everolimus and Sorafenib Using In Vitro Whole Blood Lymphocyte Proliferation", University at Buffalo, Buffalo, NY.

 

Poster Presentation (Academic)

Jusko, William (Author), Gao, Wei (Presenter), Pharmacology Day 2010, "Target-Mediated Pharmacokinetic Modeling of Exendin-4 Disposition in Rats, Monkeys and Humans", University at Buffalo, Buffalo, NY.

 

Lecture (Academic)

Jusko, William (Presenter), SUNY Upstate Cancer Research Institute Workshop, "Research Perspectives of the UB Department of Pharmaceutical Sciences", SUNY Upstate Cancer Research Institute, Syracuse NY.

 

Lecture (Academic)

Jusko, William (Presenter), Mount Sinai School of Medicine Workshop, "Systems Pharmacology of Anti-Inflammatory Effects of Corticosteroids", Mount Sinai School of Medicine, New York, NY.

 

Lecture (Non-Academic)

Jusko, William (Presenter), Drug Metabolism Department at Hoffman La Roche, "PK/PD Modeling of Anti-Inflammatory Drug Effects", Hoffman La Roche, Nutley, NJ.

 

Lecture (Academic, invited)

Jusko, William (Presenter), Frontier Science and Technology Research Foundation, "Role of Sex (Gender) in Drug Kinetics and Dynamics", Frontier Science and Technology Research Foundation, Amherst, New York.

 

Poster Presentation (Academic)

Jusko, William (Author), Pawaskar, Dipti (Author & Presenter), Almon, Richard (Author), Dubois, Debra (Author), Annual Meeting of AAPS, "Comparison of Liver and Muscle Genes for Presence of Circadian Rhythms", AAPS, Los Angeles, CA.

 

Poster Presentation (Academic)

Jusko, William (Author), Gao, Wei (Author & Presenter), Annual Meeting of AAPS, "Assessing Drug Accumulation and Half-Lives During Multiple-Dosing Conditions", AAPS, Los Angeles, CA.

 

Poster Presentation (Academic)

Jusko, William (Author), Gao, Wei (Author & Presenter), Annual Meeting of AAPS, "Target-Mediated Pharmacokinetic Modeling of Exendin-4 Disposition in Rats, Monkeys and Humans", AAPS, Los Angeles, CA.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Gao, Wei (Author & Presenter), Gao, Xiang (Author), Annual Meeting of AAPS, "Population Pharmacokinetic-Pharmacodynamic Model for the Triglyceride Lowering Effect of a PPAR Agonist:  A Phase I Study", AAPS, Los Angeles, CA.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Landersdorfer, Cornelia (Author & Presenter), American Conference on Pharmacometrics, "Pharmacokinetic/Pharmacodynamic Modeling of Glucose Clamp Effects of Inhaled Insulin", ACoP, Mashantucket, CT.

 

Poster Presentation (Academic, peer-reviewed)

Jusko, William (Author), Landersdorfer, Cornelia (Author & Presenter), He, Yan-Ling (Author), Kjems, Lise (Author), American Conference on Pharmacometrics, "Population PK/PD Modeling of the Effects of Vildagliptin on Active GLP-1, Glucose, and Insulin", ACoP, Mashantucket, CT.

 

Poster Presentation (Non-Academic, peer-reviewed)

Jusko, William (Author), Pigeolet, Etienne (Author & Presenter), Woo, Sukyung (Author), Lowe, Philip (Author), Roth, Karsten (Author), Balser, Sigrid (Author), WCN (World Congress of Nephrology), "Model-Based Comparison of Binocrit and Erypo Pharmacokinetics after Repeated I.V. and S.C. Administration", Milan, Italy.

 

Lecture

Jusko, William (Presenter), City-Wide Grand Rounds, "Role of Sex/Gender in Drug Kinetics and Dynamics", Erie County Medical Center, Buffalo, NY.

 

Poster Presentation (Academic)

Jusko, William (Author), Gao, Wei (Author & Presenter), Bihorel, Sebastien (Author), Dubois, Debra (Author), Almon, Richard (Author), Pharmacology Day 2009, "Disease Progression Model in Type 2 Diabetic Rats", Ramada Inn, Getzville NY.

 

Oral Presentation (Academic)

Jusko, William (Author), Gao, Wei (Author & Presenter), Bihorel, Sebastien (Author), Dubois, Debra (Author), Almon, Richard (Author), Pharmacology Day 2009, "Disease Progression Model in Type 2 Diabetic Rats", Ramada Inn, Getzville NY.

 

Poster Presentation (Academic)

Jusko, William (Author), Fang, Jing (Author & Presenter), Landersdorfer, Cornelia (Author), Pharmacology Day 2009, "Mechanism-Based PK/PD Model of Pramlintide in Type 1 Diabetic Patients", Ramada Inn, Getzville NY.

 

Poster Presentation (Academic)

Jusko, William (Author), Pawaskar, Dipti (Author & Presenter), Woo, Sukyung (Author), Pharmacology Day 2009, "Methods of Utilizing Baseline Values for Indirect Response Models", Ramada Inn, Getzville NY.

 

Lecture (Academic)

Jusko, William (Presenter), AAPS Workshop on Translational Biomarkers, "Gene Expression as a Pharmacodynamic Marker", Baltimore, MD.

 

Lecture (Academic)

Jusko, William (Presenter), Experimental Biology 2009 Meeting, "Systems pharmacology of anti-inflammatory effects of corticosteroids", New Orleans, LA.

 

Lecture (Non-Academic)

Jusko, William (Presenter), "Pharmacokinetic and Pharmacodynamic Modeling of Anti-inflammatory Drugs", Hoffman-LaRoche, Basel, Switzerland.

 

Lecture (Non-Academic)

Jusko, William (Presenter), "Animal Scaling of Pharmacokinetics and Pharmacodynamics", Hoffman-LaRoche, Basel, Switzerland.

 

 

<<  Previous Page