Structural PK/PD Model Building for Basic Clinical and Pre-Clinical Pharmacology Studies

Thursday, May 16 - Saturday, May 18, 2019
Niagara Falls, NY

This course is designed to fill a gap between basic population PKPD methodology training and the application of population methods to the types of studies and data often encountered by attendees in practice during the course of drug development.

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Course Director


Daniel L. Weiner, Ph.D.
Dr. Weiner has extensive drug development experience and has served as an expert consultant to the U.S. Food and Drug Administration (FDA) on pharmacokinetic modeling and bioequivalence assessment. Dr. Weiner is the co-author of Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications’ 5th ed. (2016). He is a co-developer of PCNonlin, NONLIN84, and WinNonlin and a co-designer of Phoenix NLME and has presented numerous workshops on the statistical evaluation of PKPD and bioavailability data.

Dr. Weiner is currently an industry consultant and a member of the Simulations Plus Board of Directors.  He has held previous management positions including Chief Scientific Officer and Senior Vice President at Certara/Pharsight Corporation.  Dr. Weiner is an Adjunct Associate Professor with the Division of Pharmacotherapy and Experimental Therapeutics in the School of Pharmacy, University of North Carolina and is an Affiliate Professor of Pharmacometrics, Center for Translational Medicine in the School of Pharmacy at the University of Maryland.  During his career he has provided PKPD training to over 3,000 students.

Course Agenda

Thursday, May 16, 2019
8:00 to 17:00, followed by a group dinner at 18:00

Friday, May 17, 2019
8:00 to 17:00, evening on own

Saturday, May 18, 2019
8:00 to 15:00, course adjourns

Examples will include structural population model building for:

  • Simultaneous modeling of plasma and urine data
  • Simultaneous modeling of data from different routes (e.g. iv and oral)
  • Metabolite modeling – single vs multiple metabolites, formation in plasma and/or tissue, reversible and irreversible metabolite formation, metabolites measured in plasma and/or urine
  • Modeling dual absorption such as from a controlled release formulation (containing IR and ER formulations)
  • Modeling endogenous drugs
  • TMDD modeling approaches
  • Modeling data from crossover designs

Registration Information


Individual fee is $2,800. Up to 5 graduate students may enroll at a fee of $1,400 (registered MS and PhD). The registration fee includes course documentation and temporary software license. Continental breakfasts, lunches, break-time refreshments, and opening dinner are also included. 


Cancellations with a full refund may be made until March 12, 2019. No refunds will be given for cancellations received after this date. Substitutions may be made at any time.

Course Location

The course will be held at:
The Conference and Event Center Niagara Falls
101 Old Falls Street
Niagara Falls, NY 14303, USA
Phone: (716) 278-2100
Fax: (716) 278-0008

The Conference Center is 28 minutes from the Buffalo Niagara International Airport.

Hotel Location

Sheraton at the Falls
300 Third Street
Niagara Falls, NY 14303, USA
Phone: (716) 285-3361.

The price is $93/night single and double occupancy (add $10 per person for triple and quadruple occupancy).

Hotel deadline: April 8, 2019

Questions or looking for a printable course flyer?

Contact UB course secretary Suzette Mis at (716) 645-4831 or if you need assistance.