Thursday, May 17 - Saturday, May 19, 2018
Niagara Falls, NY
Details coming soon!
David Z. D'Argenio, PhD
David D'Argenio is Professor of Biomedical Engineering at the University of Southern California and holder of the Chonette Chair of Biomedical Technology. He is a Fellow of the American Institute for Engineering in Medicine and Biology, American Association of Pharmaceutical Sciences, International Society of Pharmacometrics, a past member of the FDA Advisory Committee for Pharmaceutical Science and Clinical Pharmacology, and a founding member of the International Society of Pharmacometrics. Since 1985 he has served as co-director of the Biomedical and Simulations Resource (BMSR) at USC, which develops, applies and disseminates advanced modeling methods for studying biological systems, where he has also led the development of the ADAPT software for PK/PD modeling and analysis.
Joseph P. Balthasar, PhD
Joseph Balthasar is Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York, where he serves as the Director of the Center for Protein Therapeutics. His PK/PD modeling interests and expertise include the development and preclinical evaluation of anti-toxin immunotherapies, the development and preclinical evaluation of anti-cancer immunotherapies (including immunoconjugate immunotherapies), and the development and preclinical evaluation of novel immunotherapies for humoral autoimmune conditions (immune thrombocytopenia, myasthenia gravis). He is a consultant to the NIH and the pharmaceutical industry.
Donald E. Mager, PharmD, PhD
Donald Mager is Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York. He was also a Visiting Professor at the University Paris Descartes (Jan. 2007-2013). He currently serves on the Clinical Pharmacology Advisory Committee to the FDA, and as an Associate or Consulting Editor at CPT:Pharmacometrics & Systems Pharmacology, J. of Pharmacology & Experimental Therapeutics, and Pharmacology, Research & Perspectives. He is a Fellow of the ACCP and is President of the International Society of Pharmacometrics. His research involves identifying molecular and physiological factors that control the pharmacological properties of drugs, with a focus on anti-cancer and immunomodulatory agents.
|Saturday, May 13||Sunday, May 14
|8:00||Continental Breakfast||8:00||Continental Breakfast|
|8:30||Introductions and Overview||8:30||Case Study: PD Model for Anti-Platelet Antibodies (NPD)|
|9:00||Background: Modeling with ADAPT||9:15||Case Study: Introduction to PBPK Modeling (SIM)|
|10:30||Case Study: Target Mediated Drug Disposition (SIM)||10:30||Case Study: PBPK Modeling of IgG (SIM)|
|11:15||Case Study: Rapid Binding and MM Models (SIM)||11:15||Case Study: PBPK of mAb-ligand interaction (SIM)|
|1:00||Background: Individual Estimation||1:00||Case Study: Interferon β PK/PD (SIM)|
|2:00||Case Study: Nondepleting Anti-CD4 mAb (ID)||2:00||Case Study: Denosumab PD in Multiple Myeloma (SIM)|
|3:15||Case Study: Rituximab Extravascular Absorp. (NPD)||3:15||Background: Population Modeling with ADAPT|
|4:15||Case Study: Antibody-Antigen Interactions (SIM)||4:30||Final Q&A and Discussion|
|5:00||Recap, Looking Forward, Adjourn||5:00||Adjourn|
The fee is $2,500. Up to five (5) graduate students may enroll at a fee of $1,200 (registered MS and PhD). US Government rate: $1,900 (FDA and NIH employees only). The registration fee includes printed and electronic copies of all course materials. Continental breakfasts, lunches and break-time refreshments during the course are included.
Cancellations with a full refund may be made until March 13, 2018. No refund is possible on cancellations received after this date. Substitutions may be made at any time. Please inform course secretary of any substitutions.
The course will be held at:
The Conference and Event Center Niagara Falls
101 Old Falls Street
Niagara Falls, NY 14303, USA
Phone: (716) 278-2100
Fax: (716) 278-0008
The Conference Center is 28 minutes from the Buffalo Niagara International Airport.
Sheraton at the Falls
300 Third Street
Niagara Falls, NY 14303, USA
Phone: (716) 285-3361.
The price is $124/night single and double occupancy (add $10 per person for triple and quadruple occupancy).
Hotel deadline: April 16, 2018
Contact UB course secretary Suzette Mis at (716) 645-4831 or firstname.lastname@example.org if you need assistance.