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Brian                          Tsuji

Brian T. Tsuji PharmD

Department of Pharmacy Practice

Associate Professor

 
Professional Summary:

I am Clinical and Translational Pharm.D. Scientist and PI of R01AI111990 which seeks to investigate the Pharmacokinetics and Pharmacodynamics of Polymyxin Combinations. This R01 is interdisciplinary and blends diverse areas including microbiology and antimicrobial pharmacology with next generation sequencing and a number of infection models with an outstanding team of Pharm.D., M.D., and Ph.D. Co-Investigators. I am an internationally leading expert on antimicrobial pharmacology. In my early work in at Wayne State University, I completed new studies to optimize vancomycin dosing to combat heterogeneous resistance in Staphylococcus aureus by using PK/PD approaches to evaluate novel dosage regimens and antibiotic combinations. With the recent spread of multidrug-resistant Gram-negative bacteria, at the University at Buffalo, I developed an independent, federally funded research program, and expanded my research to refine exposure response approaches in a number of agents including colistin, polymyxin B, beta-lactams, and new combinations involving beta-lactam inhibitors against these very problematic pathogens. From 2008 to 2012, I have been a Co-investigator and PI of a subcontract at the University at Buffalo for R01A1079330 (PI Nation), a $2.3 million award from NIH. I am currently Principal Investigator of R01AI111990 a $4.4M grant which seeks to investigate the Pharmacokinetics and Pharmacodynamics of Polymyxin Combinations.

Awards and Honors:
  • Exceptional Scholar Young Investigator Award (2009)


Evaluative Studies and Case Reports:
Journal Articles:
See all (51 more)
Abstracts:
  • McClain R; Tsuji BT. Canadian Community- and Healthcare-Associated Methicillin-Resistant Staphylococcus aureus (MRSA): An Evaluation of Accessory Gene Regulator (agr) Function and Vancomycin (V) Pharmacodynamics. 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy October 25 - 28, 2008, Washington, DC. 2008.
  • Begic D; Tsuji BT. Comparative Daptomycin (DAP) and Vancomycin (VAN) Activity Against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant (SCV) Phenotype in an In Vitro Pharmacodynamic Model (IVPM). 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy October 25 - 28, 2008, Washington, DC. 2008.
  • Bulitta J; Tsuji BT. Inverse Inoculum Effect of Ciprofloxacin (CIP) and Imipenem (IMI) Against Pseudomonas aeruginosa (Pa) Characterized by New Mechanism-Based Pharmacodynamic (PD) Models. 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy October 25 - 28, 2008, Washington, DC. 2008.
  • Ly N; Tsuji BT. Mechanism-Based Pharmacokinetic / Pharmacodynamic Model for the Inverse Inoculum Effect of Imipenem against Pseudomonas aeruginosa. 2008 AAPS Annual Meeting, Atlanta, GA, USA; November 16 - 20, 2008.. 2008.
  • Takata T; Tsuji BT. Relationship Between Accessory Gene Regulator Locus with Vancomycin Bactericidal Activity and Efficacy in Methicillin-Resistant Staphylococcus aureus Bacteremia. 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy October 25 - 28, 2008, Washington, DC. 2008.
  • Wu M; Tsuji BT. Vancomycin and Daptomycin Pharmacodynamics Differ Against a Site-Directed Staphylococcus epidermidis Mutant Displaying the Small Colony Variant Phenotype. 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy October 25 - 28, 2008, Washington, DC. 2008.

Presentations:
  • "1. Yohonn L, Brown SV, Bulitta JB, Forrest A, Sun H, McPhee C, Holden PN, Kelchlin PA, Dodds Ashley E, Haas CE, Hardy D, Tsuji BT. Bactericidal Activity of Colistin against Clinical Isolates of Pseudomonas aeruginosa at High and Low Bacterial Density. Po" Annual Meeting of the Infectious Diseases Society of America & 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA; September 12 - 15, 2009., TOTAL OF 14 Abstract publications (2009)
  • "Mechanism-Based Pharmacokinetic Pharmacodynamic (PKPD) Model for the Inverse Inoculum Effect of Imipenem Against Psedomonas Aeruginosa" American Association of Pharmaceutical Sciences Meeting (2008)

School News:
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Contact Information

701 Ellicott Street
Buffalo, NY 14203
Phone: (716) 645-4796
Email: btsuji@buffalo.edu


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